Protein Alignment OtopLc and Otop1

DIOPT Version :9

• Sequence 1: NP_001303575.1
• Gene: OtopLc / 7354434
• FlyBaseID: FBgn0259150
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: NP_852098.1
• Gene: Otop1 / 305427
• RGDID: 631389
• Length: 600
• Species: Rattus norvegicus
• Alignment Length: 742
• Identity: 137/742 - (18%)
• Similarity: 254/742 - (34%)
• Gaps: 259/742 - (34%)

  Fly   815 GDRDIGGGGGPDSSDPPSSPGGSSSQP------ALSGSQADGQLALMYHSHQLTNYPVLPAIKRT 873
            |||.........|..|.::|.|.::.|      |.:..||.|
  Rat     3 GDRGALSSPAASSGSPSAAPSGIAACPPPPSPLARASPQASG----------------------- 44

  Fly   874 HRPSFVYPPMPRVKAGDALATLFSALYGKLLVVMGIAFPMA-EVISTYIPPS----------FYE 927
                    |.........||...|:.||..:.|.|:.|.:| .|.:|.:..|          ..:
  Rat    45 --------PRRGASVPQKLAETLSSQYGLNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQ 101

  Fly   928 VYYLYLYIGSMIFLLFMYATLIWGRPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPP 992
            :.::..|:|..    :|...||  |||
  Rat   102 LLWMLWYVGRS----YMQRRLI--RPK-------------------------------------- 122

  Fly   993 IPVRRPSLLSPLGRRDAHYGSFYLRMGAVAFGIGSMIYSGLEFGQYFELNPDTKCHNVLLALTPA 1057
                           |.|.|:.:||.....|...:::...|:...:...   ::|.:....:.|.
  Rat   123 ---------------DTHAGARWLRGSITLFAFITIVLGCLKVAYFIGF---SECLSATEGVFPV 169

  Fly  1058 TRMAFIFIQMYFIFLNNEQIKVYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHEILTFYNPENR 1122
            |......:|:||::.:.:.| :..:|.:.|||::|.:.|||.:|.|.::.|:||::   ...:.|
  Rat   170 THAVHTLLQVYFLWGHAKDI-IMSFKTLERFGVIHSVFTNLLLWANSVLNESKHQL---NEHKER 230

  Fly  1123 TLRISHRIPGHSRGHAII---QHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDASPFLFPCT 1184
            .:.:..       |:..|   .|.|..:...|                .:.:.:.....:|:|..
  Rat   231 LITLGF-------GNITIVLDDHTPQCNCTPP----------------ALCSALSHGIYYLYPFN 272

  Fly  1185 IEYSLICAAILYVMWRSISRPQTPTPQRPDMISSPMKRSPHHYSVDCARAHKGLFV----GILIL 1245
            |||.::.:.:|||:|::|.|       |.|        |..|..:.|  ...|:.|    |:.:|
  Rat   273 IEYQILASTMLYVLWKNIGR-------RVD--------SSRHQKMQC--RFDGVLVGSVLGLTVL 320

  Fly  1246 VLTIISLIIFFVLISRPE---------FVAMAVTEVTICELLIYGTA-TIATLVGMIQIRHLQYD 1300
            ..||..::::.:.|.|.:         |...|:|     .||:.|.| .:.:.:..:..:.|...
  Rat   321 AATIAVVVVYMIHIGRSKSKSESALIMFYLYAIT-----VLLLMGAAGLVGSWIYRVDEKSLDES 380

  Fly  1301 AYRSFSLDDILLVGAQTGSFLYNIFTVIA-------GHFTLRSDDMLVPINALASIVQTACQTMF 1358
            ...:..||..|||...:||:|.:..:::|       ..:|..:    :|.:.|. ||:...|.:|
  Rat   381 KNPARKLDADLLVATASGSWLLSWGSILAIACAETRPPYTWYN----LPYSVLV-IVEKYVQNIF 440

  Fly  1359 ILDA------------------------------------SRRQAVSPE-----HLRKKPGRE-- 1380
            |:::                                    ...|..||.     ||:::..:|
  Rat   441 IIESVHLEPEGVPEDVRTLRVVTVCSGEAAALAASSLGSQGTAQDGSPAVNGNLHLQQRCEKEDQ 505

  Fly  1381 ----------------------------IVTFMLVVNLAMWAISTLEKSRAESHPIQLNFYGLWA 1417
                                        |..|:.:.|:::|............:.::...:|...
  Rat   506 EADWEGATGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEP 570

  Fly  1418 WTIITHVSMPLAIFYRFHSTVCLCEIW 1444
            |.|:.:::||.:||||.|:...|.|::
  Rat   571 WIIVVNLAMPFSIFYRMHAAAALFEVY 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218	97/513 (19%)
Otop1	NP_852098.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		13/77 (17%)
		Otopetrin	131..586	CDD:281218	96/511 (19%)
		putative FYR-box	584..596		5/11 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880