DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OtopLc and Otop2

DIOPT Version :9

Sequence 1:	NP_001303575.1	Gene:	OtopLc / 7354434	FlyBaseID:	FBgn0259150	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001349329.1	Gene:	Otop2 / 237987	MGIID:	2388365	Length:	563	Species:	Mus musculus

Alignment Length:	532	Identity:	122/532 - (22%)
Similarity:	213/532 - (40%)	Gaps:	132/532 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   988 RLPPPIPVRRPSLLSPLGRRDAHYGSFYLRMGAVAFGIGSMIYSGLEFGQY---FELNPDTKCHN 1049
            |.|..:|.           ||||.|..:||.|.|.|||.:::....:.|.|   ||      |.:
Mouse    86 RCPDAVPY-----------RDAHAGPIWLRGGLVLFGICTLVMDVFKTGYYSSFFE------CQS 133

  Fly  1050 VLLALTPATRMAFIFIQMYFIFLNNEQIKVYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHEIL 1114
            .:..|.|..:..|:.:|.||::::.:.. ::.:..:.|.|||..:.||||:|:..::.|:.|:..
Mouse   134 AIKILHPIIQAVFVIVQTYFLWISAKDC-IHTHLDLTRCGLMFTLATNLAIWMAAVVDESVHQAH 197

  Fly  1115 TFYNPENRTLRISH-RI-PGHSRGHAIIQHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDAS 1177
            ::......|   || |: |...|.....:.||                  |..:..|..:.|...
Mouse   198 SYSGSHGNT---SHTRLNPDSKRAGGAAEEDP------------------CLCSTAICQIFQQGY 241

  Fly  1178 PFLFPCTIEYSLICAAILYVMWRSISR------PQTPTPQRPDMISSPMKRSPHHYSVDCARAHK 1236
            .:|:|..|||||..:.:|||||:::.|      ....||.|..:........|
Mouse   242 FYLYPFNIEYSLFASTMLYVMWKNVGRLLASTHGHGHTPSRVSLFRETFFAGP------------ 294

  Fly  1237 GLFVGILILVLTIISLIIFFVLISRPE-FVAMAVTEVTICELLIYGTATIATLVGMI----QIRH 1296
              .:|:|:.|:.:...|::.|.:|... ....|:.......::..|..|:.:|.|.:    ..|.
Mouse   295 --VLGLLLFVVGLAVFILYEVQVSGERGHTRQALVIYYSFNIVCLGLMTLVSLSGSVIYRFDRRA 357

  Fly  1297 LQYDAYRSFSLDDILLVGAQTGSF---LYNIFTVIAGHFTLRSDDMLVPIN---ALASIVQTACQ 1355
            :.:....:.:||..||:||..|.:   .|:|..|:.|    ...|:...:|   ||..|.|...|
Mouse   358 MDHHKNPTRTLDVALLMGAALGQYAISYYSIVAVVVG----SPRDLQGALNLSHALLMIAQHTFQ 418

  Fly  1356 TMFILDASRR----------------QAV--------------------------SPE------- 1371
            .:||:::..|                |.:                          ||:
Mouse   419 NVFIIESLHRGPPGAEPREMPPKEPCQGITFANLDAIRTLPSCPPTPRLVIPNLESPQEAVAIIS 483

  Fly  1372 ----HLRKKPGREIVTFMLVVNLAMWAISTLEKSRAESHPIQLNFYGLWAWTIITHVSMPLAIFY 1432
                |.|::..::|..|:|:.|:.:|.:.........|:.::::|||...|..|.::.:|..|||
Mouse   484 APRCHWRRRCLKDISLFLLLCNVILWIMPAFGARPHFSNTVEVDFYGYSLWAAIVNICLPFGIFY 548

  Fly  1433 RFHSTVCLCEIW 1444
            |.|:...|.|::
Mouse   549 RMHAVSSLLEVY 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218	110/493 (22%)
Otop2	NP_001349329.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
Otop2	NP_001349329.1	Otopetrin	103..549	CDD:397346	109/491 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H27803
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8758
orthoMCL	1	0.900	-	-		OOG6_105319
Panther	1	1.100	-	-	LDO	PTHR21522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.810