Protein Alignment OtopLc and otpl-8

DIOPT Version :9

• Sequence 1: NP_001303575.1
• Gene: OtopLc / 7354434
• FlyBaseID: FBgn0259150
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: NP_510045.2
• Gene: otpl-8 / 186752
• WormBaseID: WBGene00010403
• Length: 619
• Species: Caenorhabditis elegans
• Alignment Length: 687
• Identity: 177/687 - (25%)
• Similarity: 280/687 - (40%)
• Gaps: 193/687 - (28%)

  Fly   823 GGPDSSDPPSSPGGSSSQPALSGSQADGQLALMYHSHQLTNYPVLPAIKRTHRPSFVYPPMPRVK 887
            ||.||...||||                     .|.|:|...|.:      |.|          :
 Worm    32 GGSDSDSLPSSP---------------------THHHELYRRPWI------HEP----------R 59

  Fly   888 AGDALATLFSALYGKLLVVMGIAFPMAEVISTYIPPSFY--EVYYLYLYIGSMIFLLFMYATLIW 950
            |.:....|.::||..:|.::.:   :.||..|:....:.  .::|:.:|...::|..:.|..:|:
 Worm    60 ATNFFVRLITSLYALILTIISL---VVEVSPTWRTDMWLAETIFYISMYGVGILFFAYCYIFIIY 121

  Fly   951 GRPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPPIPVRRPSLLSPLGRRDAHYGSFY 1015
            ..|...:..........|.|....:.:|..:....                          |:.|
 Worm   122 PGPYNQLISVLRKYKIIKNSEVWFIMQSQHNGEGA--------------------------GTLY 160

  Fly  1016 LRMGAVAFGIGSMIYSGLEFGQYFELNPDTKCHNVLLALTPATRMAFIFIQMYFIFLNNEQIKVY 1080
            ||:||:.||...::..|||.   |....:..|..|.:| .....:.|.||||:|||.|: :|.|.
 Worm   161 LRLGALFFGSVGIVLFGLEL---FLCIENVACKKVAIA-KMIVAIVFTFIQMHFIFCNS-KITVN 220

  Fly  1081 RYKIIARFGLMHMIGTNLAVWLNVLI--QETK--------------------------HEIL--- 1114
            ..:.|..||:||:|..||..|...::  ||.|                          ||::
 Worm   221 SSRKIVAFGMMHLISVNLWTWFRFVLAKQEAKAHKKAQLKQTFRKYYSSSSSSSSEEIHELISAV 285

  Fly  1115 ---TFYN-PENRTLRISHRIPGHSRGHAIIQHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQD 1175
               |..| |..:|:.     |..||..| ::|                              ..|
 Worm   286 LNSTLNNTPATKTME-----PVASRLFA-LEH------------------------------FGD 314

  Fly  1176 ASPFLFPCTIEYSLICAAILYVMWRSISRPQTPTPQRPDMISSPMKRSPHHYSVDCARAHKGLFV 1240
            .:.||..|.:|||||.|||::::|:||.       |.....|:..||.. ...:||:.:..|||.
 Worm   315 VATFLTTCIVEYSLIGAAIMFILWKSIG-------QNNHQQSNSGKRKV-KMRIDCSSSSTGLFA 371

  Fly  1241 GILILVLTIISLIIFFVLIS-RPEFVAMAVTEVTICELLIYGTATIATLVGMIQIRHLQYDAY-R 1303
            ||:.|:.:::|:.::.:..| |....|..|  ..|.:|.::..|..|.::|:.::|||||..: .
 Worm   372 GIIFLIGSLVSMGMYTIFESLRNSSGAQLV--FGIVDLSLFSIALGACIIGLWRMRHLQYRLHAH 434

  Fly  1304 SFSLDDILLVGAQTGSFLY-----NIFTVIAGHFTLRSDDMLVPINALAS------IVQTACQTM 1357
            ...:|:|||:....|..||     ::|....     ||.|:.|  :||.:      ::|...|..
 Worm   435 GEVIDEILLIIGLIGEILYCAVGIDVFITCR-----RSADLTV--SALPAFVFVIRMIQVVVQAA 492

  Fly  1358 FILDASRRQAVSPEHLRKKPGREIVTFMLVVNLAMWAISTLE--------KSRAESHPIQLNFYG 1414
            |||..||.:.:|...::.|||:||:||:||.|:.::...|.|        .|:|.:   |.|:
 Worm   493 FILTTSRLRCLSKYSMKYKPGKEIITFLLVSNVTLFVFHTFEGMKSSFGFSSKAAT---QYNY-- 552

  Fly  1415 LWAWTIITHVSMPLAIFYRFHSTVCLCEIWKRAYKLK 1451
                  |.:...||.:||||||:.||.||||..|..|
 Worm   553 ------IIYAVGPLLVFYRFHSSACLAEIWKHTYSTK 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218	133/474 (28%)
otpl-8	NP_510045.2	Otopetrin	160..566	CDD:281218	133/474 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I2171
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	1	1.000	-	-		FOG0001932
OrthoInspector	1	1.000	-	-		mtm4740
orthoMCL	1	0.900	-	-		OOG6_105319
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.810