DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OtopLc and R10F2.6

DIOPT Version :9

Sequence 1:	NP_001303575.1	Gene:	OtopLc / 7354434	FlyBaseID:	FBgn0259150	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_497642.2	Gene:	R10F2.6 / 175405	WormBaseID:	WBGene00019997	Length:	1161	Species:	Caenorhabditis elegans

Alignment Length:	539	Identity:	103/539 - (19%)
Similarity:	186/539 - (34%)	Gaps:	147/539 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSSPDLSLKLRRGSSDSRDNF------YMDFAQGIDSDIEEVDNTANN--QEAGEVPP------ 51
            ::|...:.||:::.|:....:.      ...|....|::.::::....|  .|.|..|.
Worm    60 INSGKWIRLKVKKQSTGGEKHLAAISKNEATFEVSEDANFKKINEDIQNLKSEFGIHPRWDEELL 124

  Fly    52 PPLPTVSLAEEVLLLVAPPPPPPSLLG-----------QPLPTLTETDDIPPTPTPPPQQKDDEG 105
            ..:|:....||.|::..........||           :.|..|.||||    .:|..::.|::.
Worm   125 HAMPSTIQFEECLIIARRVKALSKKLGNEPGIFVRHIPEHLRVLLETDD----ESPDEEELDEQE 185

  Fly   106 -----DDEDEREEPV---PEQDQGA--PAAPSPPGSPINSVLELELIPPPPLSPMDDAGLRTDDD 160
                 ||.:.|:..:   .::|:.|  |...:||      ::....||..| ||....|.|...:
Worm   186 IQMVFDDLERRQSGIFYENDEDEEAQLPLLQAPP------LVSFSDIPTAP-SPKAKVGSRCYKE 243

  Fly   161 GEGEETDDAEEVAAIPPPHEMLDIESNPDEEEEEEEQEQAS-------QEDTPK----------- 207
            |   ...|||:.    |..:..:||::........|...|:       :||.|:
Worm   244 G---PLFDAEQA----PNFKYSEIETDCSVYSISSETLLANVGEVYKIREDDPRHRVKRRWPIVE 301

  Fly   208 ----------------EEDEEEDDDKSTPPPPLPPLPSNFSYVQGH----NLG--QVTPP--LTK 248
                            |.:.|||....|        .:.||..:|:    ||.  .:..|  :|.
Worm   302 KTATGRPFNLSKHFANEFESEEDGSCFT--------DTTFSLNEGNKFMKNLATWNLDDPEIVTG 358

  Fly   249 SPSN--SPSPPVTP-PPCPELNISRMVSP--------------PAQHISQIPP--LTPSDESEGE 294
            .||.  .||.|..| |...:.:..|:.:.              .|...|...|  :...|..:.:
Worm   359 FPSQILVPSLPTLPGPQAAKKHFQRIQNSGYWRSYVLKEKSDYGASETSLEEPRFVAGKDTKKSK 423

  Fly   295 AESQPNSPPLRLDAEQPPPDMD-QPEPEDQPPEPENEPEPEPEPEP-----EPEPVSGAREDYSR 353
            .:..|::||      :||.::. :..|....|.|...|..|.:.:.     :..|...|.:  .:
Worm   424 EKDPPSAPP------RPPKNLALEARPARWVPIPAKRPRGETKIDDLGRIWDVPPADEANK--LK 480

  Fly   354 SLDNEDESTTITTPPSNGYSASSIIAPPPEHFAELDEDRGFIPPPPLEQEPEEEVEEEEEEEEEE 418
            .|..::|:..:..|..:       :.||..|  :..:|...|....|..  :.:|.:..:|...:
Worm   481 DLPRQEEANLMWVPFRD-------VKPPYLH--DGSDDLRSINSQSLSS--QSDVTDWMDETRSD 534

  Fly   419 LTKETDEISVDRESLQDQG 437
            :|....|...|:|..:..|
Worm   535 VTMSESEWKGDQELAEPVG 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218
R10F2.6	NP_497642.2	Y_phosphatase	722..963	CDD:365874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900