Protein Alignment OtopLc and OTOP1

DIOPT Version :9

• Sequence 1: NP_001303575.1
• Gene: OtopLc / 7354434
• FlyBaseID: FBgn0259150
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: NP_819056.1
• Gene: OTOP1 / 133060
• HGNCID: 19656
• Length: 612
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 139/738 - (18%)
• Similarity: 262/738 - (35%)
• Gaps: 259/738 - (35%)

  Fly   819 IGGGGGPDSSDPPSSPGGSSSQPALSGSQADGQLALMYHSHQLTNYPVLPAIKRTHRPSFVYPPM 883
            :.|..||.:..||||....|                          |..||.:|..
Human    19 VAGSSGPAACSPPSSSAPRS--------------------------PESPAPRRGG--------- 48

  Fly   884 PRVKAGDALATLFSALYGKLLVVMGIAFPMA-EVISTYIPPSFYEVYYLYLYIGSMIFLLFMYAT 947
            .|......||.:.|:.||.::.|.|:...:| .|.:..:..|     .|..::.:::.|..::
Human    49 VRASVPQKLAEMLSSQYGLIVFVAGLLLLLAWAVHAAGVSKS-----DLLCFLTALMLLQLLW-- 106

  Fly   948 LIW--GRPKLPVPIASPSKSATKASGTDSMDESDTDSNSVHHRLPPPIPVRRPSLLSPLGRRDAH 1010
            ::|  ||                              :|.|.||              ...:|.|
Human   107 MLWYVGR------------------------------SSAHRRL--------------FRLKDTH 127

  Fly  1011 YGSFYLRMGAVAFGIGSMIYSGLEFGQYFELNPDTKCHNVLLALTPATRMAFIFIQMYFIFLNNE 1075
            .|:.:||.....|.:.::|...|:.|.:...   ::|.:....:.|.|......:|:||::.:.:
Human   128 AGAGWLRGSITLFAVITVILGCLKIGYFIGF---SECLSATEGVFPVTHSVHTLLQVYFLWGHAK 189

  Fly  1076 QIKVYRYKIIARFGLMHMIGTNLAVWLNVLIQETKHEILTFYNPENRTLRISHRIPGHSRGHAII 1140
            .| :..:|.:.|||::|.:.|||.:|.|.::.|:||::   ...:.|.:.:     |......::
Human   190 DI-IQSFKTLERFGVIHSVFTNLLLWANGVLNESKHQL---NEHKERLITL-----GFGNITTVL 245

  Fly  1141 -QHDPTAHLRVPRGLKGPYQIFECRRTNIIGTLVQDASPFLFPCTIEYSLICAAILYVMWRSISR 1204
             .|.|..:...|                .:.|.:.....:|:|..|||.::.:.:|||:|::|.|
Human   246 DDHTPQCNCTPP----------------TLCTAISHGIYYLYPFNIEYQILASTMLYVLWKNIGR 294

  Fly  1205 PQTPTPQRPDMISSPMKRSPHHYSVDCARAHK----------GLFVGILILVLTIISLIIFFVLI 1259
                                   .||..:..|          |..:|:.:|..||..::::.:.|
Human   295 -----------------------KVDSHQHQKMQFKSDGVMVGAVLGLTVLAATIAVVVVYLIHI 336

  Fly  1260 SRPE---------FVAMAVTEVTICELLIYGTATIATL-VGMIQIRHLQYDAYRSFSLDDILLVG 1314
            .|.:         |...|:|     .|::.|.|.:|.: :..|..:.|......:..||..||||
Human   337 GRSKTKSESALIMFYLYAIT-----LLMLMGAAGLAGIRIYRIDEKSLDESKNPARKLDSDLLVG 396

  Fly  1315 AQTGSFLYNIFTVIA-----GH--FTLRSDDMLVPINALASIVQTACQTMFILDASRRQA----- 1367
            ..:||:|.:..:::|     ||  :|..:    :|.:.|| ||:...|.:||.::..|:.
Human   397 TASGSWLISWGSILAILCAEGHPRYTWYN----LPYSILA-IVEKYIQNLFIFESIHREPEKLSE 456

  Fly  1368 -------------------------------VSPE------------------------------ 1371
                                           |:|:
Human   457 DIQTLRVVTVCNGNTMPLASSCPKSGGVARDVAPQGKDMPPAANGNVCMRESHDKEEEKQEESSW 521

  Fly  1372 ---------------HLRKKPGREIVTFMLVVNLAMWAISTLEKSRAESHPIQLNFYGLWAWTII 1421
                           :.::|..|.|..|:.:.|:::|............:.::...:|...|.|:
Human   522 GGSPSPVRLPRFLQGNAKRKVLRNIAAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIV 586

  Fly  1422 THVSMPLAIFYRFHSTVCLCEIW 1444
            .:::||.:||||.|:...|.|::
Human   587 VNLAMPFSIFYRMHAAASLFEVY 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLc	NP_001303575.1	Otopetrin	1015..1434	CDD:281218	100/527 (19%)
OTOP1	NP_819056.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		12/65 (18%)
		Otopetrin	133..598	CDD:281218	99/525 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	499..525		0/25 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8528
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.910