DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and CLMP

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_079045.1	Gene:	CLMP / 79827	HGNCID:	24039	Length:	373	Species:	Homo sapiens

Alignment Length:	371	Identity:	76/371 - (20%)
Similarity:	131/371 - (35%)	Gaps:	98/371 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLACSVKNLGSYKVAWM----HFEQSAILTVH 97
            |.:|..|....::|        |.:|:|....:.|    ....:..:.|:    ...|..::|..
Human    15 GTLGTHTEIKRVAE--------EKVTLPCHHQLGL----PEKDTLDIEWLLTDNEGNQKVVITYS 67

  Fly    98 NHVITRNPRISVTHDKHDKHRTWF----------LHINNVQEEDRGRYMCQI-NTVTAKTQYGFV 151
            :..:..|    :|.::  |.|..|          |.|..::..|.|||.|:: |:......:..:
Human    68 SRHVYNN----LTEEQ--KGRVAFASNFLAGDASLQIEPLKPSDEGRYTCKVKNSGRYVWSHVIL 126

  Fly   152 KVVVPPN-----IDDALTSSDIIVREGDNVTLRCKAKGSPEPTI-KWKRDDGNKIVINKTLEVHD 210
            ||:|.|:     ::..||       ||.::||:|::....||.: .|:|      :..|..|...
Human   127 KVLVRPSKPKCELEGELT-------EGSDLTLQCESSSGTEPIVYYWQR------IREKEGEDER 178

  Fly   211 LETDS---------LELERISRLHMGAYLCIASN--GVPPSVSKRIKVSVDFSPMV-WIPHQLVG 263
            |...|         :.|:.::..:.|.|.|.|.|  |....|   ::|:|.:...: .:...:.|
Human   179 LPPKSRIDYNHPGRVLLQNLTMSYSGLYQCTAGNEAGKESCV---VRVTVQYVQSIGMVAGAVTG 240

  Fly   264 IPIGFNITLECFIEANPTSLNYW--TRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSD 326
            |..|   .|..|       |..|  .|..|:     .:|:.|..|              |....|
Human   241 IVAG---ALLIF-------LLVWLLIRRKDK-----ERYEEEERP--------------NEIRED 276

  Fly   327 YGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTTAA 372
            ....|.....|.....|:......|..|.....:.:..:||.:|.|
Human   277 AEAPKARLVKPSSSSSGSRSSRSGSSSTRSTANSASRSQRTLSTDA 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	22/110 (20%)
		Ig	69..139	CDD:143165	16/83 (19%)
		IG_like	165..249	CDD:214653	22/95 (23%)
		IGc2	172..237	CDD:197706	19/76 (25%)
		IG_like	267..348	CDD:214653	15/82 (18%)
		Ig	270..339	CDD:299845	13/70 (19%)
CLMP	NP_079045.1	IgV_CAR_like	13..127	CDD:409552	24/129 (19%)
		Ig strand B	31..35	CDD:409552	1/3 (33%)
		Ig strand C	48..52	CDD:409552	0/3 (0%)
		Ig strand E	94..98	CDD:409552	1/3 (33%)
		Ig strand F	108..113	CDD:409552	3/4 (75%)
		Ig strand G	121..124	CDD:409552	0/2 (0%)
		IG	144..225	CDD:214652	23/96 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..373		14/73 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910