DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and mxra5b

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_017213354.1	Gene:	mxra5b / 795448	ZFINID:	ZDB-GENE-081104-119	Length:	2548	Species:	Danio rerio

Alignment Length:	425	Identity:	103/425 - (24%)
Similarity:	171/425 - (40%)	Gaps:	100/425 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VISEDPEFTDVIEN-----ITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPR 106
            |:::.|    ||.|     |.|..|....|.||.|...:..:.|:..::..|:.:.|       :
Zfish  2062 VLADAP----VIRNNAYSVIKVTYGETAILNCSAKGEPTPVITWISPDKKVIVPMTN-------K 2115

  Fly   107 ISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTA-KTQYGFVKVVVPPNIDDALTSSDII- 169
            ..:::|       ..|||:..|:.:.|.|.|...:|.. ..:...|:|:|.|.:.:......||
Zfish  2116 YQISND-------GTLHIHKTQKINSGNYTCMARSVVGIDRKVVLVEVLVFPPVINGFEHPGIIR 2173

  Fly   170 ---VREGDNVTLRCKAKGSPEPTIKWKRDD---------GNKIVI--NKTLEVHDLE-TDSLELE 219
               ||: ..|...|||.|:|.|.|.|...:         |::|.:  |.||::|.:. :||:||
Zfish  2174 KTAVRD-QRVLFDCKANGNPFPRIIWLFPNNVVLPAPYYGSRITVHRNGTLDIHAVRMSDSVEL- 2236

  Fly   220 RISRLHMGAYLCIASNGV-PPSVSKRIKVSVD-FSPMVW-IPHQLVGIPIGFNITLECFIEANPT 281
                      :|||.|.. ...:..:::|:.| ..|.:. .|...:.:.||...||.|.||.||.
Zfish  2237 ----------ICIARNEFGETKLHVKLEVTEDIIKPQLRNSPTDSIQLTIGKPTTLNCSIEGNPA 2291

  Fly   282 SLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIK 346
            ....||..|.     :|.|:..|. ....:::...|.|....|||.|.|:||.:|..|.::.|:.
Zfish  2292 PQITWTLPNG-----TSLYQGTTF-SRFHHRSDGALLIKEPSSSDAGLYRCVGRNSGGFVERNVT 2350

  Fly   347 LYMSSPPTTQPPPTTTTLRRTTTTAAEIALDGYINTPLNGNGIGIVGEGPTNSVIASGKSSIKYL 411
            |..:..|..           |...::.:::       :||..:                    :|
Zfish  2351 LVSNRKPEI-----------TNQYSSLLSI-------INGEDL--------------------HL 2377

  Fly   412 SNLNEIDKSKQKLTGSSPKGFDWSKGKSSGSHGNL 446
            ..:::. ....|||.:.|.|...|:.:|||.|..|
Zfish  2378 DCVSDA-HPPPKLTWTLPSGVVLSRAQSSGRHSVL 2411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	22/101 (22%)
		Ig	69..139	CDD:143165	15/69 (22%)
		IG_like	165..249	CDD:214653	28/100 (28%)
		IGc2	172..237	CDD:197706	23/76 (30%)
		IG_like	267..348	CDD:214653	26/80 (33%)
		Ig	270..339	CDD:299845	23/68 (34%)
mxra5b	XP_017213354.1	leucine-rich repeat	33..51	CDD:275380
		LRR_8	50..110	CDD:290566
		leucine-rich repeat	52..75	CDD:275380
		leucine-rich repeat	76..99	CDD:275380
		LRR_8	99..158	CDD:290566
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..147	CDD:275380
		LRR_8	146..213	CDD:290566
		leucine-rich repeat	148..179	CDD:275380
		leucine-rich repeat	180..203	CDD:275380
		LRRCT	212..>258	CDD:214507
		IG	472..552	CDD:214652
		Ig	477..538	CDD:143165
		IG	567..649	CDD:214652
		Ig	573..639	CDD:299845
		IG_like	1583..1666	CDD:214653
		Ig	1592..1656	CDD:299845
		I-set	1671..1763	CDD:254352
		Ig	1686..1763	CDD:299845
		IG	1776..1860	CDD:214652
		Ig	1783..1860	CDD:299845
		I-set	1875..1959	CDD:254352
		IGc2	1882..1949	CDD:197706
		IG	1979..2062	CDD:214652	103/425 (24%)
		Ig	1979..2053	CDD:299845
		I-set	2075..2156	CDD:254352	20/94 (21%)
		Ig	2082..2146	CDD:299845	17/77 (22%)
		IG	2175..2255	CDD:214652	25/91 (27%)
		Ig	2180..2255	CDD:299845	23/85 (27%)
		IG_like	2271..2351	CDD:214653	27/85 (32%)
		IGc2	2276..2343	CDD:197706	25/72 (35%)
		IG	2372..2438	CDD:214652	13/61 (21%)
		Ig	2377..2438	CDD:143165	12/36 (33%)
		IG	2462..2547	CDD:214652
		Ig	2471..2544	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11903
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000