DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Pxdn

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_006515268.1	Gene:	Pxdn / 69675	MGIID:	1916925	Length:	1503	Species:	Mus musculus

Alignment Length:	375	Identity:	93/375 - (24%)
Similarity:	160/375 - (42%)	Gaps:	58/375 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 STDTGSEG----NAGNVGGSTLNNVIS-------EDPEFTDVIENITVPAGRNVKLACSVKNLGS 80
            :|....||    .|.||.|......::       ..|.|....:|..|..|.:|.|.||......
Mouse   331 NTQEADEGVYQCMAKNVAGEAKTQEVTLRYLGSPARPTFVIQPQNTEVLVGESVTLECSATGHPL 395

  Fly    81 YKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMC-QINTVTA 144
            .::.|...:::.        :..:||:::|       .:..|:|.||.:.|.|.|.| ..|:|.:
Mouse   396 PQITWTRGDRTP--------LPIDPRVNIT-------PSGGLYIQNVAQSDSGEYTCFASNSVDS 445

  Fly   145 KTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVH 209
            .....|:.|...|..  .:|....:|.||..|..:|.|||.|:|.|.|.: .|:::.:::...|
Mouse   446 IHATAFIIVQALPQF--TVTPQSRVVIEGQTVDFQCAAKGHPQPVIAWTK-GGSQLSVDRRHLV- 506

  Fly   210 DLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVW-----IPHQLVGIPIGFN 269
             |.:.:|.:..::....|.|.|.|.|.:.   |:::...:...|.|.     ||..:. :.:|.|
Mouse   507 -LSSGTLRISGVALHDQGQYECQAVNIIG---SQKVVAHLTVQPRVTPVFASIPSDMT-VEVGTN 566

  Fly   270 ITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVA 334
            :.|.|..:..|.....|.::..| :|||.|:       |.|.:..  |||.:|.::|.|.|:|||
Mouse   567 VQLPCSSQGEPEPAITWNKDGVQ-VTESGKF-------HISPEGF--LTINDVGTADAGRYECVA 621

  Fly   335 KNPRGDMDGNIKLYMSSPPTTQ--PPPTTTTLRRTTTTAAEIALDGYINT 382
            :|..|....::.|.::.|..::  .|...|::.....|     :|..||:
Mouse   622 RNTIGYASVSMVLSVNVPDVSRNGDPYVATSIVEAIAT-----VDRAINS 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	23/96 (24%)
		Ig	69..139	CDD:143165	16/70 (23%)
		IG_like	165..249	CDD:214653	22/83 (27%)
		IGc2	172..237	CDD:197706	20/64 (31%)
		IG_like	267..348	CDD:214653	25/80 (31%)
		Ig	270..339	CDD:299845	22/68 (32%)
Pxdn	XP_006515268.1	leucine-rich repeat	94..112	CDD:275380
		leucine-rich repeat	113..127	CDD:275378
		LRR_8	115..171	CDD:338972
		LRR_8	160..219	CDD:338972
		leucine-rich repeat	161..184	CDD:275378
		leucine-rich repeat	185..208	CDD:275378
		leucine-rich repeat	209..221	CDD:275378
		TPKR_C2	217..268	CDD:387596
		I-set	271..358	CDD:369462	7/26 (27%)
		I-set	367..454	CDD:369462	24/101 (24%)
		Ig3_Peroxidasin	471..544	CDD:143222	21/78 (27%)
		Ig4_Peroxidasin	567..635	CDD:143223	23/77 (30%)
		peroxidasin_like	889..1328	CDD:188658
		VWC	1439..1494	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910