DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-epsilon and Btnl9

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_038943086.1	Gene:	Btnl9 / 684480	RGDID:	1590287	Length:	529	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	68/355 - (19%)
Similarity:	122/355 - (34%)	Gaps:	99/355 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 ENITVPAGRNVKLAC---SVKNLGSYKVAWMHFEQSAILTVHNHVITR-NPRISVTHDKHDKHRT 119
            |:|....|..|:..|   |.::.|..::.|...:.|.::.::.....| ||:::     ..::||
  Rat    45 ESILARVGEAVEFPCRLSSYQDAGYMEILWFRTQVSNVVYLYQEPQGRSNPQMA-----QFRNRT 104

  Fly   120 WF-----------LHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREG 173
            .|           |||.:|...|.|||.|:..:.....:..:...|.....|..::....   .|
  Rat   105 LFEAYDIGEGSVNLHILSVVPSDEGRYGCRFLSHNFSGEATWELEVAGLGSDPHISLEGF---NG 166

  Fly   174 DNVTLRCKAKG-SPEPTIKWKRDDGNKIVINKTLEVHDLETD-----SLELERISR--LHMGAYL 230
            :.:.|:|.:.| .|:|.::|:......:    :.|..|:..:     |||...|.|  .|... .
  Rat   167 EGIQLQCSSSGWYPKPKVQWRGHQDQCL----SPESEDITQNAQGLFSLETSVIVRGGTHSNV-S 226

  Fly   231 CIASNGVPPSVSKRIKVSVDFSPMVWIPH----------QLVGIPIGFNITLECFIEANPTSLNY 285
            ||..|.:.|...:.:....|    |::|.          .||.:|:       |.:.....:|.|
  Rat   227 CIIQNPLLPQKKEFVLQIAD----VFLPRTSPWKKAFVGTLVVLPL-------CLVALAVLALRY 280

  Fly   286 WTR-----ENDQMITESSKYKTET---------------------------IPGHPSYK------ 312
            :.:     ||.....|..:.|.:|                           ...|||.:
  Rat   281 FYKQRRFQENRVKQGEQDREKLQTELDWRRSEGQAEWRAAQQYAVDVTLDPATAHPSLEVSNNRK 345

  Fly   313 -ATMRLTITNVQSSD---YGNYKCVAKNPR 338
             .:.||.:.:..:.|   :....||....|
  Rat   346 SVSSRLGVPSTAAGDPQRFSEQTCVLSRER 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/110 (22%)
		Ig	69..139	CDD:143165	21/84 (25%)
		IG_like	165..249	CDD:214653	19/91 (21%)
		IGc2	172..237	CDD:197706	18/72 (25%)
		IG_like	267..348	CDD:214653	17/114 (15%)
		Ig	270..339	CDD:299845	17/111 (15%)
Btnl9	XP_038943086.1	Ig	40..151	CDD:416386	24/110 (22%)
		FR1	40..61	CDD:409353	5/15 (33%)
		Ig strand A	40..43	CDD:409353
		Ig strand A'	46..50	CDD:409353	1/3 (33%)
		Ig strand B	53..61	CDD:409353	2/7 (29%)
		CDR1	62..70	CDD:409353	2/7 (29%)
		Ig strand C	70..75	CDD:409353	0/4 (0%)
		FR2	71..75	CDD:409353	0/3 (0%)
		CDR2	76..94	CDD:409353	2/17 (12%)
		Ig strand C'	80..88	CDD:409353	1/7 (14%)
		Ig strand C'	89..92	CDD:409353	0/2 (0%)
		FR3	96..136	CDD:409353	12/44 (27%)
		Ig strand D	103..108	CDD:409353	3/4 (75%)
		Ig strand E	114..122	CDD:409353	3/7 (43%)
		Ig strand F	129..137	CDD:409353	4/7 (57%)
		CDR3	137..139	CDD:409353	0/1 (0%)
		Ig strand G	139..151	CDD:409353	0/11 (0%)
		FR4	140..151	CDD:409353	0/10 (0%)
		Ig	157..234	CDD:416386	18/84 (21%)
		SPRY_PRY_C-I_1	326..500	CDD:293968	9/50 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910