DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Kirrel3

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_006510620.1	Gene:	Kirrel3 / 67703	MGIID:	1914953	Length:	803	Species:	Mus musculus

Alignment Length:	585	Identity:	120/585 - (20%)
Similarity:	191/585 - (32%)	Gaps:	176/585 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FLY---VGL---GCLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNV 69
            ||:   :||   ||.:.... ::.|.....|.|.|..      .|:.|      ::..|.:|:.|
Mouse    14 FLFSQELGLQKRGCCLVLGY-MAKDKFRRMNEGQVYS------FSQQP------QDQVVVSGQPV 65

  Fly    70 KLACSVKNLGSYKVAWM-------------HFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWF 121
            .|.|::.....: |.|:             .:.|  .|.|.||       :|..|         .
Mouse    66 TLLCAIPEYDGF-VLWIKDGLALGVGRDLSSYPQ--YLVVGNH-------LSGEH---------H 111

  Fly   122 LHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKA-KGS 185
            |.|...:.:|...|.||......:::...:.|:|||:....|....|.:|.||.:.|.|.| ...
Mouse   112 LKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPIILGGPVISLRAGDPLNLTCHADNAK 176

  Fly   186 PEPTIKWKRDDG--NKIVINKTLEVHDLETDSLELERISRLHMG--------AYLCIASN-GVPP 239
            |..:|.|.|...  |....:||| :.|.:.:|:    :|.|.:.        :.:|.|:| .:|.
Mouse   177 PAASIIWLRKGEVINGATYSKTL-LRDGKRESI----VSTLFISPGDVENGQSIVCRATNKAIPG 236

  Fly   240 SVSKRIKVSVDFSPMVWI---PHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESS--- 298
            .....:.:.:...|:|.:   |..::...|   :|..|..:|||....|...:...:|.|:|
Mouse   237 GKETSVTIDIQHPPLVNLSVEPQPVLEDNI---VTFHCSAKANPAVTQYRWAKRGHIIKEASGEL 298

  Fly   299 -------KYKTETIP----------------------------------------------GHPS 310
                   .|.:|.:.                                              |:||
Mouse   299 YRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTSEPQSLLVDLGSDAVFSCAWIGNPS 363

  Fly   311 YKAT-------------MRLTITNVQSSDYGNYKCVAKNPR-GDMDGNIKLYMSSPPTTQPPPTT 361
            ....             ..||:.:|:..|.|.|.|.|..|| |..:..:.|.::.||......|.
Mouse   364 LTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQ 428

  Fly   362 TTLR----------RTTTTAAEIALDGYINTPLNGNGIGIVGEGPTNSV-IASGKSSIKYLSNLN 415
            ..|.          |:|.....||.....|...:|..    |.....:| ...|..|...:||:.
Mouse   429 HALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTS----GRYTVETVNTEEGVISTLTISNIV 489

  Fly   416 EID-KSKQKLTGSSPKGFDW------SKGKSSGSHGNLMASSWPLICCI----------LALLTT 463
            ..| ::....|..:..|.|.      .:|....|...|.|.|.|:...|          |.|:.|
Mouse   490 RADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMAT 554

Fly 464 463
Mouse 555 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	21/108 (19%)
		Ig	69..139	CDD:143165	17/82 (21%)
		IG_like	165..249	CDD:214653	23/95 (24%)
		IGc2	172..237	CDD:197706	20/76 (26%)
		IG_like	267..348	CDD:214653	25/150 (17%)
		Ig	270..339	CDD:299845	24/138 (17%)
Kirrel3	XP_006510620.1	IG_like	54..143	CDD:214653	21/113 (19%)
		Ig strand A'	56..60	CDD:409353	0/3 (0%)
		Ig strand B	64..71	CDD:409353	3/6 (50%)
		Ig strand C	78..82	CDD:409353	2/3 (67%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	1/5 (20%)
		Ig strand E	104..116	CDD:409353	6/27 (22%)
		Ig strand G	132..143	CDD:409353	0/10 (0%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	24/101 (24%)
		Ig strand B	166..170	CDD:409416	1/3 (33%)
		Ig strand C	180..184	CDD:409416	1/3 (33%)
		Ig strand E	210..214	CDD:409416	2/3 (67%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	11/66 (17%)
		Ig strand B	267..274	CDD:409353	2/6 (33%)
		Ig strand C	279..286	CDD:409353	1/6 (17%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	1/5 (20%)
		Ig strand G	321..334	CDD:409353	0/12 (0%)
		Ig	335..416	CDD:416386	15/80 (19%)
		Ig strand A'	343..347	CDD:409353	0/3 (0%)
		Ig strand B	350..360	CDD:409353	0/9 (0%)
		Ig strand C	365..371	CDD:409353	0/5 (0%)
		Ig strand E	381..387	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	418..515	CDD:409479	20/100 (20%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	2/3 (67%)
		Ig strand E	481..485	CDD:409479	1/3 (33%)
		Ig strand F	496..501	CDD:409479	0/4 (0%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810