DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Hmcn2

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_006498564.1	Gene:	Hmcn2 / 665700	MGIID:	2677838	Length:	5092	Species:	Mus musculus

Alignment Length:	557	Identity:	138/557 - (24%)
Similarity:	211/557 - (37%)	Gaps:	150/557 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GLGCLIA----SSVALSTDTGSEGNAGNVGGSTLNN----------VISEDPEFTDVIENITVPA 65
            ||..::|    .|..|......|.:||......:|.          |:...|..||..:::||..
Mouse   736 GLEVILAPGDSRSGTLRIPEAQERDAGLYTCKAVNELGDASAEIQLVVGNAPRLTDPPQDVTVEL 800

  Fly    66 GRNVKLACSVKNLGSYKVAW-----------------------MHFEQ----------------- 90
            |::|.|.|.........|.|                       :.||:
Mouse   801 GKSVFLTCRATGRPPPIVTWRRGDGQALEPGRGSRTGQRDSGVLVFERVSLEDQAPYVCEARNVF 865

  Fly    91 -----SAILTVHNH-------------VITRNPRISVT-----------------------HDKH 114
                 .|.|.|..|             |:...| :|:|                       .::|
Mouse   866 GKAQAEARLVVTGHAPPQIANSASVVRVLEGQP-VSLTCVILAGRPLPERRWLKAGSPLPPGNRH 929

  Fly   115 DKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVV--VPPNIDDALTSSDIIVREGDNVT 177
            .......||::...:||.|||.| :.|..|.:|:..|::|  |||.|..  ||:..:..||...:
Mouse   930 AVRADGSLHLDRALQEDAGRYSC-VATNVAGSQHRDVELVVQVPPRIHP--TSTHHVTNEGVPAS 991

  Fly   178 LRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVS 242
            |.|.|.|.|.|.|.|.::. |.:..:....|.  ...:|.:.:.|....|||:|.|:|.|..| |
Mouse   992 LPCIASGVPTPKITWTKET-NALTTSGHYSVS--RNGTLVIVQPSPQDAGAYVCTATNSVGFS-S 1052

  Fly   243 KRIKVSVDFSPMVWI-PHQLVGIPI------GFNITLECFIEANPTSLNYWTRENDQMITESSKY 300
            :.:.:||:..||:.: ..|.|.:|:      |..:||:|..:.:||.|..||::.:.::..:::|
Mouse  1053 QEMWLSVNTKPMIKMNGSQAVDVPLRVTVKAGEEVTLDCEAQGSPTPLLTWTKDANPLLPVTNRY 1117

  Fly   301 KTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTTLR 365
              |.:|     ..::||  ...|..|.|.|.|.|.||.|.......|.:..||..||.|
Mouse  1118 --ELLP-----SGSLRL--AQAQVGDNGLYGCTASNPAGATSRRYVLRVQVPPQVQPGP------ 1167

  Fly   366 RTTTTAAEIALDGYINTPLNGN----------GIGIVGEGPTNSV-IASGKSSIKYL-----SNL 414
            |.....|..|||  :|....||          |:.::|||...|| .|:.|:|...|     ||.
Mouse  1168 RVLKVLAGEALD--LNCVAEGNPQPQLNWFKDGMALMGEGAQGSVHFAAVKTSDAGLYRCEASNS 1230

  Fly   415 NEIDKSKQKLTGSSPKGFDWSKGKS-----SGSHGNL 446
            ...|..|.:|....|..:...:.||     :|.:.:|
Mouse  1231 AGTDTWKLELLVLEPPHWGTDETKSLLERVAGENASL 1267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	32/178 (18%)
		Ig	69..139	CDD:143165	24/150 (16%)
		IG_like	165..249	CDD:214653	24/83 (29%)
		IGc2	172..237	CDD:197706	20/64 (31%)
		IG_like	267..348	CDD:214653	23/80 (29%)
		Ig	270..339	CDD:299845	21/68 (31%)
Hmcn2	XP_006498564.1	vWFA	38..196	CDD:238119
		Ig	445..511	CDD:319273
		IG	525..605	CDD:214652
		I-set	609..693	CDD:369462
		IG	707..783	CDD:214652	9/46 (20%)
		IG_like	793..876	CDD:214653	12/82 (15%)
		I-set	889..969	CDD:369462	17/81 (21%)
		Ig	992..1058	CDD:386229	21/69 (30%)
		IG	1076..1157	CDD:214652	25/89 (28%)
		Ig	1161..1242	CDD:386229	27/88 (31%)
		Ig	1262..1336	CDD:386229	2/6 (33%)
		I-set	1345..1429	CDD:369462
		I-set	1449..1523	CDD:369462
		IG	1553..1633	CDD:214652
		IGc2	1654..1716	CDD:197706
		Ig	1741..1819	CDD:386229
		Ig	1839..1903	CDD:386229
		I-set	1907..1986	CDD:369462
		Ig_3	1998..2073	CDD:372822
		Ig	2092..2179	CDD:386229
		Ig	2183..2273	CDD:386229
		Ig	2291..2367	CDD:386229
		IGc2	2389..2451	CDD:197706
		I-set	2476..2554	CDD:369462
		I-set	2558..2650	CDD:369462
		I-set	2668..2740	CDD:369462
		Ig	2782..2859	CDD:386229
		I-set	2876..2954	CDD:369462
		I-set	2966..3046	CDD:369462
		I-set	3050..3141	CDD:369462
		Ig	3145..3233	CDD:386229
		Ig	3256..3320	CDD:319273
		Ig	3347..3422	CDD:386229
		IG_like	3436..3511	CDD:214653
		IGc2	3530..3592	CDD:197706
		Ig	3614..3695	CDD:386229
		I-set	3699..3786	CDD:369462
		Ig	3789..3874	CDD:386229
		Ig	3900..3967	CDD:319273
		I-set	3974..4060	CDD:369462
		Ig	4064..4151	CDD:386229
		I-set	4155..4240	CDD:369462
		IGc2	4259..4321	CDD:197706
		I-set	4335..4421	CDD:369462
		G2F	4423..4605	CDD:369383
		FXa_inhibition	4664..4699	CDD:373209
		EGF_CA	4701..4744	CDD:311536
		EGF_CA	4746..4783	CDD:214542
		EGF_CA	4789..4829	CDD:214542
		EGF_CA	4896..4935	CDD:214542
		EGF_CA	4936..4974	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910