DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and ush2a

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	502	Identity:	95/502 - (18%)
Similarity:	162/502 - (32%)	Gaps:	175/502 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LEAISSFLYVGLGCLIASSVALSTDTGS------EGNAGNVGGSTLNNVISEDPEFTDVIENI-- 61
            |.|.:.:.|..:.|.:|..|.    :|.      ||....|....|:::       |....|:
Zfish  4349 LNAYTLYSYAIIACTVAGCVT----SGPTQIRTLEGAPATVDSPILSDI-------TSYSLNVSW 4402

  Fly    62 TVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINN 126
            |||:.:|.::..                  .||.|:|..:.|..|:|
Zfish  4403 TVPSFQNGEIVV------------------YILKVNNDEVYRGKRLS------------------ 4431

  Fly   127 VQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIK 191
            ||..|...::.....:||.|..|            ..:||.|:::     |......|.|.||:|
Zfish  4432 VQVLDLQPHVSYSIILTACTNGG------------CTSSSPILIQ-----TREAPPSGMPAPTLK 4479

  Fly   192 ----------WK--------------RDDGNKIVINKTLEVHDLE-TDSLELERISRLHMGAYLC 231
                      |:              |.:|:.|........||.. ..|:|.         :|..
Zfish  4480 VTGPESVEVTWREPVHPNGVIMGYELRRNGSLIYTGTDTRYHDFTLLPSVEY---------SYTI 4535

  Fly   232 IASNG-----VPPSVSK------------RIKVSVDFSPMV-W-IPHQLVGIPIGFNITLECFIE 277
            .|:|.     .||:|::            |::....||.|| | .|.:..|:.|.:::     .:
Zfish  4536 TANNSEGATTSPPAVARTQPSAPSGVAPPRLQALGPFSVMVKWDPPARPNGVIISYSL-----YK 4595

  Fly   278 ANPTSLNY--WTRENDQMITESSKYKTETIPGHPSYKATMRL---TITNVQSSDYGNYKCVAKNP 337
            .:|...|.  :...:.....:|..:...|:  .|.|:..:|:   ::....:||:.:.:.:...|
Zfish  4596 RDPAENNVKRFVFASHHSAFQSRSFSLNTL--KPYYRYEVRVEACSLLGCAASDWSSIQTLESPP 4658

  Fly   338 RG------DMDGNIK-----LYMSSPPTTQP--------------------PPTTTTLRRTTTTA 371
            .|      ::..|.|     ..:|..|.|:|                    ..||.....::|:.
Zfish  4659 AGQPAPLLELQTNPKGLQTVFLLSWSPPTEPNGKLLHYELYRKHLSDMESRSVTTLVYSDSSTSC 4723

  Fly   372 AEIALDGYINTPLN---GNGIGIVG----EGPTNSVIASGKSSIKYL 411
            .:..|..|......   .|..|..|    :|.|......|.||.|:|
Zfish  4724 HDDKLQPYTAYEYQVWAVNSAGRAGSPWAQGHTGPAPPEGISSPKFL 4770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	19/97 (20%)
		Ig	69..139	CDD:143165	10/69 (14%)
		IG_like	165..249	CDD:214653	24/125 (19%)
		IGc2	172..237	CDD:197706	17/94 (18%)
		IG_like	267..348	CDD:214653	13/96 (14%)
		Ig	270..339	CDD:299845	10/73 (14%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470	4/16 (25%)
		FN3	4382..4465	CDD:238020	25/142 (18%)
		FN3	4470..4553	CDD:238020	19/91 (21%)
		FN3	4555..4653	CDD:238020	18/104 (17%)
		FN3	4679..4753	CDD:238020	12/73 (16%)
		fn3	4760..4830	CDD:278470	5/11 (45%)
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900