DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and robo4

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	256	Identity:	63/256 - (24%)
Similarity:	99/256 - (38%)	Gaps:	75/256 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 HDKHRTWFLHINNVQEEDR------GRYMCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVRE 172
            |.:||  .:| ......||      .|.:.:||         ..::|..|        ||::||.
Zfish    40 HLRHR--LMH-QRASHRDRAHRRKGSRLVSEIN---------LPRIVHHP--------SDVVVRV 84

  Fly   173 GDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELE------------------ 219
            |...||.|:|:|:|||||:|.|:.            ..|:||.::.:
Zfish    85 GSPATLSCRAEGNPEPTIQWLRNG------------QPLDTDKMDAQSQPIVLPDGSLFFFSVVP 137

  Fly   220 -RISRLHMGAYLCIASNGVPPSVSKRIKVSV-----DFSPMVWIPHQLVGIPIGFNITLECFIEA 278
             |..:.|...|.|||.|.:..:.|:...:.:     ||.    :....|.:.||...|:.|....
Zfish   138 GRKGQSHEAVYACIAHNSIGNATSRNASLHIAALREDFR----VQPSDVEVAIGEMATINCSPPV 198

  Fly   279 NPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRG 339
            .....|...|::..:|..|:::.|| :.|        :|.|...|.:|.|.|.|:|.|..|
Zfish   199 GHPEPNVTWRKDGILINSSNEHYTE-LKG--------KLIIAPAQKNDSGVYSCIASNMIG 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	9/46 (20%)
		Ig	69..139	CDD:143165	7/30 (23%)
		IG_like	165..249	CDD:214653	28/102 (27%)
		IGc2	172..237	CDD:197706	23/83 (28%)
		IG_like	267..348	CDD:214653	20/73 (27%)
		Ig	270..339	CDD:299845	18/68 (26%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	30/118 (25%)
		I-set	71..168	CDD:254352	30/116 (26%)
		I-set	175..261	CDD:254352	23/89 (26%)
		Ig2_Robo	177..261	CDD:143201	22/83 (27%)
		I-set	265..350	CDD:254352
		Ig	282..350	CDD:299845
		FN3	373..448	CDD:214495
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900