DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and lrig1

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_688817.4	Gene:	lrig1 / 560325	ZFINID:	ZDB-GENE-031113-23	Length:	1022	Species:	Danio rerio

Alignment Length:	332	Identity:	74/332 - (22%)
Similarity:	120/332 - (36%)	Gaps:	51/332 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PEFTDVIENITVPA--GRNVKLACSVKNLGSYKVAWMHFEQSAIL---TVHNHVITRNPRISVTH 111
            |:.|  :..:|..|  |::|:|.|:..:..|..:.:...:....|   .|.|....|      ..
Zfish   486 PQIT--VHPVTTAAVLGKDVRLTCTAASSSSSPMTFTWLKDQETLRQAEVENFAHVR------AS 542

  Fly   112 DKHDKHRTWFLHINNVQEEDRGRYMCQINT-----------VTAKTQYGFVKVVVPPNIDDALTS 165
            |......|..||:.:|.....|||.|.|:.           ||......|||           |.
Zfish   543 DGGVMEYTTILHLRHVTFNHEGRYQCIISNHFGSSYSNKARVTVNVLPSFVK-----------TP 596

  Fly   166 SDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDL-ETDSLELERISRLHMGAY 229
            .||.:|.|....|.|.|:|.|.|.:.|::|.|......:...:..: :.|...:..:....||.|
Zfish   597 RDITIRTGTKARLECAAEGHPTPQVAWQKDGGTDFPAARERRMRVMPDDDVFFIMDVKPEDMGVY 661

  Fly   230 LCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMI 294
            .|.|.| ....:|..:.::|..:|.:....:...:.:|..:.|:|....:|.....|.:..:.:.
Zfish   662 SCTAKN-TAGMISANVTLTVLETPHLAQEMEDRNVVVGETVALQCKALGSPPPRITWLKGEEPLR 725

  Fly   295 TESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKL-----YMSSPPT 354
            .....:.|   ||:      ..|.|.:....|.|.|.||..|..|....:.:|     :....|.
Zfish   726 ASDRHHFT---PGN------QLLVIGSSTLEDAGRYTCVMSNTLGTERAHSQLTVYQRFEECAPF 781

  Fly   355 TQPPPTT 361
            |.|...|
Zfish   782 TSPSTVT 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	26/111 (23%)
		Ig	69..139	CDD:143165	17/72 (24%)
		IG_like	165..249	CDD:214653	21/84 (25%)
		IGc2	172..237	CDD:197706	17/65 (26%)
		IG_like	267..348	CDD:214653	18/85 (21%)
		Ig	270..339	CDD:299845	15/68 (22%)
lrig1	XP_688817.4	LRRNT	31..63	CDD:214470
		leucine-rich repeat	63..84	CDD:275380
		LRR_RI	77..334	CDD:238064
		LRR_8	83..142	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380
		LRR_8	132..191	CDD:290566
		leucine-rich repeat	132..155	CDD:275380
		leucine-rich repeat	156..180	CDD:275380
		leucine-rich repeat	181..203	CDD:275380
		LRR_8	202..262	CDD:290566
		leucine-rich repeat	204..227	CDD:275380
		leucine-rich repeat	228..251	CDD:275380
		LRR_8	251..310	CDD:290566
		leucine-rich repeat	252..275	CDD:275380
		leucine-rich repeat	276..299	CDD:275380
		LRR_8	299..358	CDD:290566
		leucine-rich repeat	300..323	CDD:275380
		leucine-rich repeat	324..347	CDD:275380
		leucine-rich repeat	348..372	CDD:275380
		LRR_4	373..414	CDD:289563
		LRR_8	374..433	CDD:290566
		leucine-rich repeat	375..398	CDD:275380
		leucine-rich repeat	399..420	CDD:275380
		LRRCT	433..481	CDD:214507
		Ig_3	485..572	CDD:290638	23/93 (25%)
		IG_like	492..586	CDD:214653	22/99 (22%)
		I-set	590..680	CDD:254352	25/101 (25%)
		Ig_1	607..681	CDD:143240	17/74 (23%)
		I-set	684..771	CDD:254352	19/95 (20%)
		IGc2	698..761	CDD:197706	16/71 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910