DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-epsilon and NTM

DIOPT Version :9

Sequence 1:NP_001137799.1 Gene:DIP-epsilon / 7354433 FlyBaseID:FBgn0259714 Length:467 Species:Drosophila melanogaster
Sequence 2:NP_001338930.1 Gene:NTM / 50863 HGNCID:17941 Length:367 Species:Homo sapiens


Alignment Length:343 Identity:108/343 - (31%)
Similarity:165/343 - (48%) Gaps:37/343 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 VISEDPEFTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTH 111
            |.|.|..|...::|:||..|.:..|.|::.|..: :|||::  :|.||...|.....:||:.:..
Human    31 VRSGDATFPKAMDNVTVRQGESATLRCTIDNRVT-RVAWLN--RSTILYAGNDKWCLDPRVVLLS 92

  Fly   112 DKHDKHRTWFLHINNVQEEDRGRYMCQINTVT-AKTQYGFVKVVVPPNIDDALTSSDIIVREGDN 175
            :...::.   :.|.||...|.|.|.|.:.|.. .||....:.|.|.|.|.:  .||||.:.||:|
Human    93 NTQTQYS---IEIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVE--ISSDISINEGNN 152

  Fly   176 VTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPS 240
            ::|.|.|.|.||||:.|:.       |:........|.:.||::.|:|...|.|.|.|||.|...
Human   153 ISLTCIATGRPEPTVTWRH-------ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 210

  Fly   241 VSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETI 305
            |.:|:||:|::.|.: ...:..|:|:|...||:|...|.|::...|.:::.::|......|.|..
Human   211 VVRRVKVTVNYPPYI-SEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVKVENR 274

  Fly   306 PGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTT 370
            |      ...:|...||...|||||.|||.|..|..:.:|.|:..:.||     ::|.|:...||
Human   275 P------FLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFELNEPT-----SSTLLQEVKTT 328

  Fly   371 AAEIALDGYINTPLNGNG 388
            |.         ||..|.|
Human   329 AL---------TPWKGPG 337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-epsilonNP_001137799.1 IG_like 59..155 CDD:214653 27/96 (28%)
Ig 69..139 CDD:143165 19/69 (28%)
IG_like 165..249 CDD:214653 33/83 (40%)
IGc2 172..237 CDD:197706 24/64 (38%)
IG_like 267..348 CDD:214653 25/80 (31%)
Ig 270..339 CDD:299845 22/68 (32%)
NTMNP_001338930.1 Ig 44..132 CDD:416386 26/93 (28%)
Ig strand A' 44..49 CDD:409353 3/4 (75%)
Ig strand B 51..59 CDD:409353 2/7 (29%)
CDR1 59..63 CDD:409353 1/3 (33%)
FR2 64..70 CDD:409353 3/6 (50%)
Ig strand C 64..70 CDD:409353 3/6 (50%)
CDR2 71..83 CDD:409353 4/11 (36%)
Ig strand C' 72..76 CDD:409353 2/3 (67%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 9/36 (25%)
Ig strand D 87..94 CDD:409353 1/6 (17%)
Ig strand E 97..103 CDD:409353 0/8 (0%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 1/3 (33%)
Ig strand G 123..132 CDD:409353 2/8 (25%)
FR4 125..132 CDD:409353 1/6 (17%)
Ig_3 136..205 CDD:404760 28/77 (36%)
Ig strand A' 142..147 CDD:409353 4/4 (100%)
Ig strand B 153..160 CDD:409353 2/6 (33%)
Ig strand C 166..171 CDD:409353 2/4 (50%)
Ig strand D 177..180 CDD:409353 0/2 (0%)
Ig strand E 184..190 CDD:409353 2/5 (40%)
Ig strand F 197..204 CDD:409353 3/6 (50%)
Ig strand G 211..219 CDD:409353 4/7 (57%)
Ig_3 222..299 CDD:404760 25/83 (30%)
putative Ig strand A 223..229 CDD:409353 1/6 (17%)
Ig strand B 239..243 CDD:409353 2/3 (67%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 1/3 (33%)
Ig strand F 292..297 CDD:409353 3/4 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143443
Domainoid 1 1.000 45 1.000 Domainoid score I12195
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H41139
Inparanoid 1 1.050 141 1.000 Inparanoid score I4481
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - mtm8497
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3058
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.830

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