DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and OPCML

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001306032.1	Gene:	OPCML / 4978	HGNCID:	8143	Length:	354	Species:	Homo sapiens

Alignment Length:	359	Identity:	106/359 - (29%)
Similarity:	162/359 - (45%)	Gaps:	45/359 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ISSFLYVGLGCLIASSVAL--STDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVK 70
            :..:|::...||:..|:.|  ...||....:|             |..|...::|:||..|.:..
Human     3 VCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSG-------------DATFPKAMDNVTVRQGESAT 54

  Fly    71 LACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRY 135
            |.|::.:..: :|||::  :|.||...|...:.:||:.:..:...::.   :.|.||...|.|.|
Human    55 LRCTIDDRVT-RVAWLN--RSTILYAGNDKWSIDPRVIILVNTPTQYS---IMIQNVDVYDEGPY 113

  Fly   136 MCQINTVT-AKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKR---DD 196
            .|.:.|.. .||....:.|.|||.|.:  .||||.|.||.:|||.|.|.|.||||:.|:.   .:
Human   114 TCSVQTDNHPKTSRVHLIVQVPPQIMN--ISSDITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKE 176

  Fly   197 GNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQL 261
            |...|         .|.:.||:..|.|...|.|.|.|.|.|.....:::|::|::.|.: ...:.
Human   177 GQGFV---------SEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKITVNYPPYI-SKAKN 231

  Fly   262 VGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATM-RLTITNVQSS 325
            .|:.:|....|.|...|.|.:...|.:|..::.|.....:.|.       |..| .||..||...
Human   232 TGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIEN-------KGRMSTLTFFNVSEK 289

  Fly   326 DYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPP 359
            |||||.|||.|..|:.:.:|.||..||.:....|
Human   290 DYGNYTCVATNKLGNTNASITLYEISPSSAVAGP 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	26/96 (27%)
		Ig	69..139	CDD:143165	18/69 (26%)
		IG_like	165..249	CDD:214653	32/86 (37%)
		IGc2	172..237	CDD:197706	25/67 (37%)
		IG_like	267..348	CDD:214653	26/81 (32%)
		Ig	270..339	CDD:299845	23/69 (33%)
OPCML	NP_001306032.1	Ig	44..132	CDD:416386	25/93 (27%)
		Ig strand A'	44..49	CDD:409353	3/4 (75%)
		Ig strand B	51..59	CDD:409353	2/7 (29%)
		CDR1	59..63	CDD:409353	0/3 (0%)
		FR2	64..70	CDD:409353	3/6 (50%)
		Ig strand C	64..70	CDD:409353	3/6 (50%)
		CDR2	71..83	CDD:409353	4/11 (36%)
		Ig strand C'	72..76	CDD:409353	2/3 (67%)
		Ig strand C'	80..83	CDD:409353	0/2 (0%)
		FR3	84..118	CDD:409353	9/36 (25%)
		Ig strand D	87..94	CDD:409353	1/6 (17%)
		Ig strand E	97..103	CDD:409353	0/8 (0%)
		Ig strand F	110..118	CDD:409353	3/7 (43%)
		CDR3	119..123	CDD:409353	1/3 (33%)
		Ig strand G	123..132	CDD:409353	2/8 (25%)
		FR4	125..132	CDD:409353	1/6 (17%)
		Ig_3	135..206	CDD:404760	32/81 (40%)
		Ig strand A	135..138	CDD:409353	2/2 (100%)
		Ig strand A'	144..148	CDD:409353	2/3 (67%)
		Ig strand B	151..160	CDD:409353	4/8 (50%)
		Ig strand C	165..170	CDD:409353	2/4 (50%)
		Ig strand C'	171..174	CDD:409353	0/2 (0%)
		Ig strand F	198..206	CDD:409353	4/7 (57%)
		Ig	224..312	CDD:416386	28/95 (29%)
		putative Ig strand A	224..230	CDD:409353	1/6 (17%)
		Ig strand B	240..244	CDD:409353	1/3 (33%)
		Ig strand C	253..257	CDD:409353	0/3 (0%)
		Ig strand E	279..283	CDD:409353	1/3 (33%)
		Ig strand F	293..298	CDD:409353	3/4 (75%)
		Ig strand G	306..309	CDD:409353	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143437
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830