DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and negr1

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	340	Identity:	100/340 - (29%)
Similarity:	151/340 - (44%)	Gaps:	50/340 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EFTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKH 117
            ::|...|::....|....|.|.:.: |..|.||::  :|:|:...|...:.:||:|:..:..|||
Zfish    39 DYTTSSESVVSRQGDTALLRCYLLD-GISKGAWLN--RSSIIYAGNDKWSGDPRVSIVSNVGDKH 100

  Fly   118 RTWFLHINNVQEEDRGRYMCQINT---VTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLR 179
            . :.|.|..|...|.|.|.|.|.:   :..|.....||  |||.|.|  .||||.|.||.||:|.
Zfish   101 E-YSLQIQKVDVTDEGVYTCSIQSERNLHPKLIQLIVK--VPPKIYD--ISSDITVNEGSNVSLI 160

  Fly   180 CKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKR 244
            |.|.|.|||.|.|:.       |:.:...:: ..:.|.:..|||...|.|.|.|.|.:....:|.
Zfish   161 CAASGKPEPKISWRH-------ISPSARKYE-SGEYLNITGISRDQAGDYECGAENDIASPDTKT 217

  Fly   245 IKVSVDFSPMVWIPHQLV--GIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTE---- 303
            ::|:|:|.|.:   |::.  |:..|....|.|...|.|:.:..|             ||.|
Zfish   218 VRVTVNFPPAI---HEMKSHGVRPGQVALLRCEAAAVPSPVFEW-------------YKGEKRIN 266

  Fly   304 ----TIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQ---PPPTT 361
                .:..:.|.::.  ||:.|:....||||.|||.|..|..:.::.|.....|||.   ..|.:
Zfish   267 MGQGIVINNLSSRSV--LTVKNMTQDRYGNYTCVAVNRLGTANASVPLNPIIEPTTTSAVSSPAS 329

  Fly   362 TTLRRTTTTAAEIAL 376
            ......:|..||:.|
Zfish   330 NPAMYGSTGGAEVLL 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	28/98 (29%)
		Ig	69..139	CDD:143165	22/69 (32%)
		IG_like	165..249	CDD:214653	30/83 (36%)
		IGc2	172..237	CDD:197706	23/64 (36%)
		IG_like	267..348	CDD:214653	22/88 (25%)
		Ig	270..339	CDD:299845	20/76 (26%)
negr1	XP_009300786.1	Ig	42..121	CDD:299845	24/82 (29%)
		IG_like	44..136	CDD:214653	26/95 (27%)
		I-set	140..222	CDD:254352	33/91 (36%)
		IGc2	153..208	CDD:197706	22/62 (35%)
		IG_like	236..312	CDD:214653	22/90 (24%)
		IGc2	238..304	CDD:197706	21/80 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750