DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and LSAMP

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	307	Identity:	98/307 - (31%)
Similarity:	146/307 - (47%)	Gaps:	24/307 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EFTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKH 117
            :|....:||||..|....|.|.|::..| ||||::  :|.|:...:...:.:||:.: ..:|...
Human    33 DFNRGTDNITVRQGDTAILRCVVEDKNS-KVAWLN--RSGIIFAGHDKWSLDPRVEL-EKRHSLE 93

  Fly   118 RTWFLHINNVQEEDRGRYMCQINTV-TAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCK 181
              :.|.|..|...|.|.|.|.:.|. ..||...::.|.|||.|.:  .|||:.|.||.||||.|.
Human    94 --YSLRIQKVDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISN--ISSDVTVNEGSNVTLVCM 154

  Fly   182 AKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIK 246
            |.|.|||.|.|:.       :..|....:.|.:.||:..|:|...|.|.|.|:|.|..:..|::|
Human   155 ANGRPEPVITWRH-------LTPTGREFEGEEEYLEILGITREQSGKYECKAANEVSSADVKQVK 212

  Fly   247 VSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSY 311
            |:|::.|.: ...:......|...:|:|...|.|.....|.|: |..|..::..:.::..|..|
Human   213 VTVNYPPTI-TESKSNEATTGRQASLKCEASAVPAPDFEWYRD-DTRINSANGLEIKSTEGQSS- 274

  Fly   312 KATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPP 358
                 ||:|||....||||.|||.|..|..:.::.|:....||...|
Human   275 -----LTVTNVTEEHYGNYTCVAANKLGVTNASLVLFKRVLPTIPHP 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	29/96 (30%)
		Ig	69..139	CDD:143165	20/69 (29%)
		IG_like	165..249	CDD:214653	33/83 (40%)
		IGc2	172..237	CDD:197706	25/64 (39%)
		IG_like	267..348	CDD:214653	25/80 (31%)
		Ig	270..339	CDD:299845	23/68 (34%)
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	28/95 (29%)
		Ig	132..215	CDD:386229	35/91 (38%)
		Ig_3	219..294	CDD:372822	24/82 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143409
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3058
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.830