DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-epsilon and Gm1123

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001074245.1	Gene:	Gm1123 / 382097	MGIID:	2685969	Length:	390	Species:	Mus musculus

Alignment Length:	371	Identity:	84/371 - (22%)
Similarity:	137/371 - (36%)	Gaps:	89/371 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 YMCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEP----TIKWKRD 195
            ::|.:.     ...|.|.:..|..     |..::   :|:.|.|.|....|||.    .|:|.|.
Mouse     9 FLCGVT-----DHIGSVSITTPEQ-----TIQEV---QGETVHLPCMFTLSPEDQGPLDIEWLRL 60

  Fly   196 DG-------NKIVINKTLEVH-DLETD-----------------SLELERISRLHMGAYLCIASN 235
            .|       :.|::....::: |...|                 |:::..:.....|.|||....
Mouse    61 SGPNNEAMDHVIILYAVDKIYSDFYQDMRGRVNFTSNGITSGEASIKIRDVQPADSGTYLCKVKT 125

  Fly   236 GVPPSVSK-RIKVS-VDF--SPMVWIPHQLVGIPIGFNITLEC---FIEANPTSLNY-WTR---- 288
            .  |.|:| .:::: ||:  |..:..|.|.:....|..:.|.|   ||..:...||. |.|
Mouse   126 A--PGVAKTTVQLTVVDYIGSVSITTPEQTIEKDQGETVHLPCMFTFISKDQGPLNIEWLRLSGP 188

  Fly   289 ENDQMITESSKYKTETIPG--HPSYKATMRLT------------ITNVQSSDYGNYKCVAKNPRG 339
            .|:.|......|..:.|..  :|..|..:..|            |||||.||.|.|:|..|...|
Mouse   189 NNEAMDHVVILYSADKIHDDVYPDLKGRVYFTSNDIKSGDASINITNVQLSDAGTYQCKVKTYPG 253

  Fly   340 DMDGNIKL----YMSSPPTTQPPPTTTTLR-RTTTTAAEIALDGYINTPLNGNGIGIVGEGPTNS 399
            .::.|::|    ::.|...|.|..|....| .|........|....:.||..:.:.:.  ||.|.
Mouse   254 TVNRNLQLAVTDHIGSVSITTPEQTIQKARGETVHLPCTFTLSPEDHGPLFIDWMQLT--GPQNE 316

  Fly   400 VIASGKSSIKYLS-----NLNEIDKSKQKLTGSSPKGFDWSKGKSS 440
            |:  .:..|.||:     |..:..|.:.:.|.:     |...|::|
Mouse   317 VV--NRMFIVYLADKIYDNFYQDMKGRVQFTSN-----DIRSGEAS 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	3/19 (16%)
		Ig	69..139	CDD:143165	1/3 (33%)
		IG_like	165..249	CDD:214653	22/114 (19%)
		IGc2	172..237	CDD:197706	19/93 (20%)
		IG_like	267..348	CDD:214653	30/106 (28%)
		Ig	270..339	CDD:299845	26/90 (29%)
Gm1123	NP_001074245.1	V-set	24..139	CDD:284989	24/124 (19%)
		IG_like	25..138	CDD:214653	24/122 (20%)
		V-set	149..264	CDD:284989	32/114 (28%)
		IG_like	152..263	CDD:214653	31/110 (28%)
		V-set	274..389	CDD:284989	20/91 (22%)
		IG_like	277..388	CDD:214653	19/88 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910