DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and cntn5

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_956098.1	Gene:	cntn5 / 327429	ZFINID:	ZDB-GENE-030131-5640	Length:	1056	Species:	Danio rerio

Alignment Length:	344	Identity:	86/344 - (25%)
Similarity:	141/344 - (40%)	Gaps:	75/344 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHV---ITRNPRISVTHDKHDKHRTWFL 122
            ::|..|:.|.|.|:..:         |..:.....|.|.:   :..:.|..::.:      |..|
Zfish   163 VSVREGQGVVLMCAPPS---------HSPEIIYSWVFNELPSFVAEDSRRFISQE------TGNL 212

  Fly   123 HINNVQEEDRGRYMCQI-NTVTAKTQYGFVKVVVPP-----NID----------DALTSSDIIVR 171
            :|..||..|.|.|:||: ||||.      .:|:.||     ..|          :|.....::..
Zfish   213 YIPKVQPSDVGSYVCQVKNTVTN------ARVLSPPTPLTLKTDGVMGEYEPKIEAHFPQTVLAA 271

  Fly   172 EGDNVTLRCKAKGSPEPTIKWKRDDGN---KIVINKTLEVHDLETDSLELERISRLHMGAYLCIA 233
            :|..|.|.|.|.|:|.|||.|::..||   |..:.|:..|  ||..:::||     ..|:|.|.|
Zfish   272 KGVTVRLECFALGNPVPTITWRKMSGNIPKKARLRKSQAV--LEIPNIQLE-----DSGSYECKA 329

  Fly   234 SNGVPPSVSKRIKVSVDFSPMVWIPHQLVG---IPIGFNITLECFIEANPTSLNYWTRENDQMIT 295
            .| .....:.|..:.|...|. ||  .::.   :..|..:..||.....|.....|.|..:.:.|
Zfish   330 EN-TRGGTAFRGHLQVYTLPQ-WI--SMINDTQLDSGEQLRWECRATGKPRPTYRWLRNGEPLST 390

  Fly   296 ESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDM--DGNIKLYMSSPPTTQPP 358
            :|   :.|.:.|        .|||..:|.:|.|.|:|:|:|..|.:  ...:|:..|:|.....|
Zfish   391 QS---RVEMVNG--------ELTIHRLQQADSGMYQCIAENKYGAIYSSAELKILASAPMFNNNP 444

  Fly   359 PTTTTLRRTTTTAAEIALD 377
                 :|...|...:::|:
Zfish   445 -----VRLIATVGKDVSLE 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/97 (25%)
		Ig	69..139	CDD:143165	16/72 (22%)
		IG_like	165..249	CDD:214653	26/86 (30%)
		IGc2	172..237	CDD:197706	25/67 (37%)
		IG_like	267..348	CDD:214653	22/82 (27%)
		Ig	270..339	CDD:299845	19/68 (28%)
cntn5	NP_956098.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Ig	56..149	CDD:299845
		Ig	151..245	CDD:299845	26/102 (25%)
		IG_like	163..236	CDD:214653	23/93 (25%)
		Ig	258..345	CDD:299845	27/94 (29%)
		IG_like	265..344	CDD:214653	26/86 (30%)
		I-set	348..433	CDD:254352	24/98 (24%)
		Ig	349..433	CDD:299845	23/97 (24%)
		I-set	438..524	CDD:254352	5/26 (19%)
		Ig	452..524	CDD:299845	1/7 (14%)
		I-set	534..623	CDD:254352
		Ig	543..627	CDD:299845
		FN3	627..722	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..736
		FN3	732..824	CDD:238020
		FN3	833..925	CDD:238020
		FN3	933..1020	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910