DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Lrig2

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001101180.1	Gene:	Lrig2 / 310753	RGDID:	1309554	Length:	1054	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	98/462 - (21%)
Similarity:	157/462 - (33%)	Gaps:	110/462 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VGGSTLNNVISED--------PEFTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAIL- 94
            :.|.::.||..:|        |:.....||.....|.||.|.|:..:.....::.:..:.|.||
  Rat   476 LAGQSILNVDLKDFVCDDFLKPQIRTHPENTVALRGVNVTLMCTAVSSSDSPMSTLWRKDSEILY 540

  Fly    95 --TVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINT-----------VTAKT 146
              .:.|.|..|.      .|......|..|.:.:|...|.|:|.|.:..           :|...
  Rat   541 DVDIENFVRYRQ------QDGEALEYTSVLRLFSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNE 599

  Fly   147 QYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDL 211
            ...|:|           |..|:.:|.|....|.|.|:|.|.|.|.|::|.|......:...:|.:
  Rat   600 MPSFLK-----------TPMDLTIRTGAMARLECAAEGHPTPQISWQKDGGTDFPAARERRMHVM 653

  Fly   212 -ETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECF 275
             |.|...:..:....||.|.|:|.| :...:|....::|..:|....|.:...:..|....|:|.
  Rat   654 PEDDVFFIANVKIEDMGIYSCMAQN-IAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCI 717

  Fly   276 IEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGD 340
            ...:|.....||:::..::.      ||.   |....|...|.|.:....|.|.|.|:..|..|.
  Rat   718 AGGSPAPRLNWTKDDGPLLV------TER---HFFAAANQLLIIVDAGLEDAGKYTCLMSNTLGT 773

  Fly   341 MDGNIKLYMSSPPTTQPPPTTTTLRRTTTTAAEIALDGYINTPLNGNGIGIVGEGPTN------- 398
            ..|:|.|.:.|.|                           |...:.|.||...:|.|.
  Rat   774 ERGHIYLNVISSP---------------------------NCDSSQNSIGHEDDGWTTVGIVIIV 811

  Fly   399 ---SVIASG------------KSSIKYLSNLNEID--------KSKQKLTGSSPKGFDWSKGKSS 440
               .|:.:.            |.....::|..|::        .|.|.......:|:..|:   :
  Rat   812 VVCCVVGTSLIWVIVIYHMRRKDEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSE---A 873

  Fly   441 GSHGNLM 447
            |||..||
  Rat   874 GSHQQLM 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/109 (22%)
		Ig	69..139	CDD:143165	17/72 (24%)
		IG_like	165..249	CDD:214653	23/84 (27%)
		IGc2	172..237	CDD:197706	20/65 (31%)
		IG_like	267..348	CDD:214653	20/80 (25%)
		Ig	270..339	CDD:299845	16/68 (24%)
Lrig2	NP_001101180.1	LRR_RI	<50..204	CDD:238064
		leucine-rich repeat	98..120	CDD:275380
		LRR_8	119..178	CDD:290566
		leucine-rich repeat	121..144	CDD:275380
		LRR_RI	136..398	CDD:238064
		leucine-rich repeat	145..167	CDD:275380
		LRR_8	167..226	CDD:290566
		leucine-rich repeat	168..192	CDD:275380
		leucine-rich repeat	193..215	CDD:275380
		leucine-rich repeat	216..239	CDD:275380
		LRR_8	239..298	CDD:290566
		leucine-rich repeat	240..263	CDD:275380
		leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		LRR_8	311..370	CDD:290566
		leucine-rich repeat	312..335	CDD:275380
		leucine-rich repeat	336..359	CDD:275380
		LRR_8	358..421	CDD:290566
		leucine-rich repeat	360..384	CDD:275380
		LRR_4	385..426	CDD:289563
		leucine-rich repeat	387..410	CDD:275380
		leucine-rich repeat	411..433	CDD:275380
		LRRCT	444..492	CDD:214507	4/15 (27%)
		Ig	501..597	CDD:299845	21/101 (21%)
		IG	503..597	CDD:214652	21/99 (21%)
		I-set	601..691	CDD:254352	26/101 (26%)
		Ig_1	618..692	CDD:143240	20/74 (27%)
		I-set	695..782	CDD:254352	23/95 (24%)
		Ig	713..782	CDD:299845	20/77 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910