DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Igsf9

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	108/518 - (20%)
Similarity:	177/518 - (34%)	Gaps:	139/518 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLACSVKNLGS-- 80
            ||..:.::|....|::|.              ..||...|:..    ||.:..|.|.:.....
  Rat     4 CLRLTILSLILSQGADGR--------------RKPEVVSVVGR----AGESAVLGCDLLPPAGRP 50

  Fly    81 --YKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTW-FLHINNVQEEDRGRYMCQINTV 142
              :.:.|:.|  ..:|.:.......:|||...:....:.:|. .|.|..::.||:|.|.|::..:
  Rat    51 PLHVIEWLRF--GFLLPIFIQFGLYSPRIDPDYVGRVRLQTGASLQIEGLRVEDQGWYECRVLFL 113

  Fly   143 T--------AKTQYGFVKVVVPPNIDDALTSSDII-VREGDNVTLRCKAKGSPEPTIKWK----- 193
            .        |...:..:.|..||...:  |...:: |:|.:.|||||.|.|||:|.:.||
  Rat   114 DQHSPEQDFANGSWVHLTVNSPPQFQE--TPPLVLEVKELEAVTLRCVALGSPQPYVTWKFRGQD 176

  Fly   194 --RDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVW 256
              :..|...|.|.||.:          .|:.|...|.|.|.||: ...||:...::.|...|::.
  Rat   177 LGKGQGQVQVRNGTLWI----------RRVERGSAGDYTCQASS-TEGSVTHTTQLLVLGPPVIV 230

  Fly   257 IPHQLVGIPIGFNITLECFIEANPTSLNY-WTRENDQMITESSKYKTET---IPGHPSYKATMRL 317
            :|.....:....:::|.|..||.|.:|.| |.::... :...|:.::..   :.|....:||
  Rat   231 VPPNNNTVNASQDVSLACRAEAYPANLTYSWFQDRIN-VFHISRLQSRVRILVDGSLWLQAT--- 291

  Fly   318 TITNVQSSDYGNYKCVAKN------------------------PRGDMDGNIKLYMSSPPTTQPP 358
                 |..|.|:|.||..|                        |...:...::..:..|....||
  Rat   292 -----QPDDAGHYTCVPSNGFPHPPSASAYLTVLYPAQVTVMPPETPLPIGMRGVIRCPVRANPP 351

  Fly   359 PTTTTLRR---------------------TTTTAAEIALDGYINTPLNGNGIGIVGEGPTNSVIA 402
            ....|..:                     ......|.||..|..||.  |.:|..|..|...|:.
  Rat   352 LLFVTWTKDGQALQLDKFPGWSLGPEGSLVIALGNEDALGEYSCTPY--NSLGTAGSSPVTRVLL 414

  Fly   403 SGKSSIKYLSNLNEIDKSKQK--------------LTGSSPKGFDWSK-GKSSGSHGNLMASS 450
            ....:.        ||:.|::              ..|..|....|:| |:  |..|.....|
  Rat   415 KAPPAF--------IDQPKEEYFQEVGRDLLIPCSARGDPPPIVSWAKVGR--GLQGQAQVDS 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	20/108 (19%)
		Ig	69..139	CDD:143165	16/74 (22%)
		IG_like	165..249	CDD:214653	28/91 (31%)
		IGc2	172..237	CDD:197706	25/71 (35%)
		IG_like	267..348	CDD:214653	20/108 (19%)
		Ig	270..339	CDD:299845	20/96 (21%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	19/87 (22%)
		Ig strand A	136..139	CDD:409353	1/2 (50%)
		IG_like	143..223	CDD:214653	28/90 (31%)
		Ig strand A'	145..148	CDD:409353	0/2 (0%)
		Ig strand B	154..161	CDD:409353	5/6 (83%)
		Ig strand C	167..172	CDD:409353	1/4 (25%)
		Ig strand C'	175..177	CDD:409353	0/1 (0%)
		Ig strand D	183..187	CDD:409353	0/3 (0%)
		Ig strand E	189..193	CDD:409353	2/3 (67%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	2/9 (22%)
		Ig_3	226..305	CDD:404760	20/87 (23%)
		putative Ig strand A	226..230	CDD:409353	1/3 (33%)
		putative Ig strand A'	235..239	CDD:409353	0/3 (0%)
		putative Ig strand B	241..251	CDD:409353	2/9 (22%)
		putative Ig strand C'	267..270	CDD:409353	0/3 (0%)
		putative Ig strand D	279..282	CDD:409353	0/2 (0%)
		putative Ig strand E	284..290	CDD:409353	1/5 (20%)
		putative Ig strand F	297..305	CDD:409353	4/7 (57%)
		putative Ig strand G	310..319	CDD:409353	0/8 (0%)
		Ig	322..407	CDD:416386	14/86 (16%)
		Ig strand A'	324..328	CDD:409353	0/3 (0%)
		Ig strand B	333..347	CDD:409353	1/13 (8%)
		Ig strand C	353..359	CDD:409353	1/5 (20%)
		Ig strand C'	362..364	CDD:409353	0/1 (0%)
		Ig strand D	371..374	CDD:409353	0/2 (0%)
		Ig strand E	378..382	CDD:409353	0/3 (0%)
		Ig strand F	391..399	CDD:409353	3/9 (33%)
		Ig	418..503	CDD:416386	11/60 (18%)
		Ig strand A	418..421	CDD:409353	0/10 (0%)
		Ig strand A'	427..430	CDD:409353	0/2 (0%)
		Ig strand B	436..443	CDD:409353	0/6 (0%)
		Ig strand C	449..454	CDD:409353	1/4 (25%)
		Ig strand C'	457..459	CDD:409353	0/3 (0%)
		Ig strand D	462..466	CDD:409353	0/3 (0%)
		Ig strand E	469..473	CDD:409353
		Ig strand F	482..490	CDD:409353
		Ig strand G	493..503	CDD:409353
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000