DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-epsilon and Cntn6

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_037357.1	Gene:	Cntn6 / 27256	RGDID:	62008	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	97/451 - (21%)
Similarity:	169/451 - (37%)	Gaps:	94/451 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AGNVGGSTLNN---VISEDPEFTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVH 97
            |||:.|..|..   :....||:...|:|..:....::...|......:....|:  :....|...
  Rat   299 AGNLRGRNLAKGQLIFYAPPEWEQKIQNTYLSIYDSLFWECKASGNPNPSYTWL--KNGERLNTE 361

  Fly    98 NHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMC----QINTVTAKTQYGFVKVVV-PP 157
            ..:.|.|..:.:|          .|:::     |.|.|.|    :..|:.|..:   ::|:. .|
  Rat   362 ERIQTENGTLIIT----------MLNVS-----DSGIYQCAAENKYQTIYANAE---LRVLASAP 408

  Fly   158 NIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERIS 222
            :..........:|:.|.::::.||....|:.:|.|||...|   :.::..|..||..||::..::
  Rat   409 DFSKNPIKKISVVQVGGDISIECKPNAFPKASISWKRGTEN---LKQSKRVFFLEDGSLKICNVT 470

  Fly   223 RLHMGAYLCIASN--GVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTS--L 283
            |...|:|.|:|:|  |...|....|   |....::.:|...:.:.:|.:|.|.|.:..:||.  |
  Rat   471 RSDAGSYTCVATNQFGNGKSSGSLI---VKERTVITVPPSKMDVTVGESIVLPCQVSHDPTMEVL 532

  Fly   284 NYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKC---------------V 333
            ..|....|.:..:......|.|.|    ::...|.|.|:|....|.|.|               :
  Rat   533 FVWYFNGDVIDLKKGVAHFERIGG----ESVGDLMIRNIQLGHSGKYLCTVQTTLERLSAVADII 593

  Fly   334 AKNPRGDMDGNIKLYMSSPPTTQ----PPPTTTT--------------------------LRRTT 368
            .:.|.|..: ::|:...|..|:|    |.|...:                          |...|
  Rat   594 VRGPPGPPE-DVKVEHISSTTSQLSWRPGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGQT 657

  Fly   369 TTAAEIALDGYINTPLN---GNGIGIVGEGPTNSVIASGKSSIKYLS--NLNEIDKSKQKL 424
            ..|..|.|..::.....   ||.||| ||....|.:...|:||..::  |:|....|:.:|
  Rat   658 YNATVIGLSPWVEYEFRVVAGNNIGI-GEPSKPSELLRTKASIPNVAPVNINGGGGSRSEL 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	15/99 (15%)
		Ig	69..139	CDD:143165	11/73 (15%)
		IG_like	165..249	CDD:214653	24/85 (28%)
		IGc2	172..237	CDD:197706	20/66 (30%)
		IG_like	267..348	CDD:214653	22/97 (23%)
		Ig	270..339	CDD:299845	19/85 (22%)
Cntn6	NP_037357.1	Ig strand D	76..80	CDD:409353
		Ig strand E	82..88	CDD:409353
		Ig strand F	95..104	CDD:409353
		Ig strand G	107..120	CDD:409353
		Ig	129..214	CDD:416386
		Ig strand A	130..135	CDD:409353
		Ig strand B	139..145	CDD:409353
		Ig strand C	153..159	CDD:409353
		Ig strand C'	164..166	CDD:409353
		Ig strand D	171..176	CDD:409353
		Ig strand E	179..183	CDD:409353
		Ig strand F	193..201	CDD:409353
		Ig strand G	203..214	CDD:409353
		Ig	227..315	CDD:416386	5/15 (33%)
		Ig strand A	227..232	CDD:409353
		Ig strand A'	235..240	CDD:409353
		Ig strand B	243..252	CDD:409353
		Ig strand C	258..262	CDD:409353
		Ig strand C'	265..267	CDD:409353
		Ig strand D	276..279	CDD:409353
		Ig strand E	280..285	CDD:409353
		Ig strand F	293..301	CDD:409353	1/1 (100%)
		Ig strand G	304..315	CDD:409353	2/10 (20%)
		Ig	319..403	CDD:416386	16/103 (16%)
		Ig strand A	319..322	CDD:409353	1/2 (50%)
		Ig strand A'	326..330	CDD:409353	1/3 (33%)
		Ig strand B	334..342	CDD:409353	1/7 (14%)
		Ig strand C	348..353	CDD:409353	1/6 (17%)
		Ig strand C'	355..358	CDD:409353	0/2 (0%)
		Ig strand D	363..367	CDD:409353	0/3 (0%)
		Ig strand E	369..374	CDD:409353	0/4 (0%)
		Ig strand F	383..390	CDD:409353	2/6 (33%)
		Ig strand G	394..403	CDD:409353	2/11 (18%)
		Ig5_Contactin	408..496	CDD:409358	25/93 (27%)
		Ig strand B	427..431	CDD:409358	0/3 (0%)
		Ig strand C	440..444	CDD:409358	1/3 (33%)
		Ig strand E	462..466	CDD:409358	2/3 (67%)
		Ig strand F	476..481	CDD:409358	2/4 (50%)
		Ig strand G	489..492	CDD:409358	1/2 (50%)
		Ig	500..598	CDD:416386	20/101 (20%)
		Ig strand A'	507..512	CDD:409353	0/4 (0%)
		Ig strand B	515..523	CDD:409353	3/7 (43%)
		Ig strand C	532..536	CDD:409353	1/3 (33%)
		Ig strand E	560..564	CDD:409353	1/3 (33%)
		Ig strand F	573..580	CDD:409353	3/6 (50%)
		Ig strand G	587..591	CDD:409353	0/3 (0%)
		FN3	598..691	CDD:238020	19/94 (20%)
		FN3	703..796	CDD:238020	4/15 (27%)
		FN3	805..898	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..908
		FN3	903..983	CDD:214495
		Ig	26..120	CDD:416386
		Ig strand A	27..31	CDD:409353
		Ig strand A'	34..39	CDD:409353
		Ig strand B	45..53	CDD:409353
		Ig strand C	58..64	CDD:409353
		Ig strand C'	66..69	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910