DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and MXRA5

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_056234.2	Gene:	MXRA5 / 25878	HGNCID:	7539	Length:	2828	Species:	Homo sapiens

Alignment Length:	384	Identity:	99/384 - (25%)
Similarity:	153/384 - (39%)	Gaps:	55/384 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IASSVALSTDTGSEGNAGNVGGSTLNNV--ISEDPE-FTDVIENITVPAGRNVKLACSVKNLGSY 81
            |.|||..|.......:....||...:..  :.|.|: .|...:.::|.|..:....|........
Human  1819 ITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPKP 1883

  Fly    82 KVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKT 146
            .|.|......|::|.:    ||..|..|.     |:.|  |.|..||.:|||:|||     ||..
Human  1884 FVTWTKVSTGALMTPN----TRIQRFEVL-----KNGT--LVIRKVQVQDRGQYMC-----TASN 1932

  Fly   147 QYGFVKVVV-------PPNIDDALTS--SDIIVREGDNVTLRCKAKGSPEPTIKW----KRDDGN 198
            .:|..::||       .|.|   |.|  .|:.|..||.:.:.|.|||:|.|.|.|    :|....
Human  1933 LHGLDRMVVLLSVTVQQPQI---LASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQT 1994

  Fly   199 KIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGV-PPSVSKRIKVSVDFSPMVWIPHQ-- 260
            ...:...:.:|  |..:|.::..|....|.|.|:|||.. ..|::.|:.|:. ..|::   ||
Human  1995 VSPVEGRITLH--ENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAA-LPPVI---HQEK 2053

  Fly   261 --LVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQ 323
              .:.:|.|.:|.:.|..:|.|.....|...:...|..|     :.:.|:........|.|.|:.
Human  2054 LENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPS-----QFLHGNLFVFPNGTLYIRNLA 2113

  Fly   324 SSDYGNYKCVAKN----PRGDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTTAAEIALDG 378
            ..|.|.|:|||.|    .|..:..|::...::...|...|..|.:|...|...:.:..|
Human  2114 PKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASG 2172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	26/95 (27%)
		Ig	69..139	CDD:143165	21/69 (30%)
		IG_like	165..249	CDD:214653	27/90 (30%)
		IGc2	172..237	CDD:197706	21/68 (31%)
		IG_like	267..348	CDD:214653	21/84 (25%)
		Ig	270..339	CDD:299845	18/72 (25%)
MXRA5	NP_056234.2	leucine-rich repeat	38..55	CDD:275380
		LRR_8	55..115	CDD:290566
		LRR 1	56..77
		leucine-rich repeat	57..80	CDD:275380
		LRR 2	80..101
		leucine-rich repeat	81..104	CDD:275380
		LRR_8	102..163	CDD:290566
		LRR 3	104..125
		leucine-rich repeat	105..128	CDD:275380
		LRR_4	128..168	CDD:289563
		LRR 4	128..149
		leucine-rich repeat	129..152	CDD:275380
		LRR 5	152..173
		leucine-rich repeat	153..184	CDD:275380
		LRR 6	184..205
		leucine-rich repeat	185..208	CDD:275380
		LRRCT	217..>263	CDD:214507
		IG	486..572	CDD:214652
		IGc2	493..558	CDD:197706
		IG	590..668	CDD:214652
		IGc2	591..658	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..715
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..962
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1190
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1275
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1367..1389
		LRR 7	1410..1434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1479..1499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1536..1566
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1669..1689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1700..1719
		IG_like	1860..1945	CDD:214653	28/100 (28%)
		Ig	1868..1945	CDD:299845	26/92 (28%)
		I-set	1958..2042	CDD:254352	25/85 (29%)
		IGc2	1965..2032	CDD:197706	21/68 (31%)
		I-set	2047..2139	CDD:254352	24/99 (24%)
		Ig	2065..2137	CDD:299845	19/76 (25%)
		IG_like	2153..2238	CDD:214653	5/20 (25%)
		Ig	2161..2229	CDD:299845	2/12 (17%)
		IG	2258..2341	CDD:214652
		Ig	2258..2332	CDD:299845
		IG_like	2356..2435	CDD:214653
		Ig	2361..2435	CDD:299845
		I-set	2440..2535	CDD:254352
		Ig	2459..2535	CDD:299845
		IG	2549..2633	CDD:214652
		Ig	2561..2633	CDD:299845
		IG	2652..2728	CDD:214652
		Ig	2655..2724	CDD:143165
		IG_like	2741..2827	CDD:214653
		Ig	2751..2824	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910