DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-epsilon and HMCN2

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001278744.1	Gene:	HMCN2 / 256158	HGNCID:	21293	Length:	5079	Species:	Homo sapiens

Alignment Length:	558	Identity:	125/558 - (22%)
Similarity:	201/558 - (36%)	Gaps:	164/558 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GLGCLIA----SSVALSTDTGSEGNAGNVGGSTLNNV----------ISEDPEFTDVIENITVPA 65
            ||..::|    ||..|......|.:||......:|.:          :...|:.|::..::||..
Human   735 GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL 799

  Fly    66 GRNVKLACSVKNLGSYKVAW---------------------------MHFEQSA----------- 92
            ||:..|||.........|.|                           :.||..|
Human   800 GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEA 864

  Fly    93 -------------ILTVH--NHVITRNPRISVTH------------------------------- 111
                         |:|.|  ..:.:..|.:.|..
Human   865 RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPG 929

  Fly   112 DKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVV--VPPNIDDALTSSDIIVREGD 174
            .:|.......||::...:|..|||.| :.|.||.:|:..|::|  |||.|..  |::..|..||.
Human   930 SRHSIRADGSLHLDRALQEHAGRYSC-VATNTAGSQHRDVELVVQVPPRIHP--TATHHITNEGV 991

  Fly   175 NVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPP 239
            ..:|.|.|.|.|.|||.|.::  ...:.::....:..:..:|.:.:.|....|||:|.|:|.|..
Human   992 AASLPCVASGVPAPTITWTKE--TNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGF 1054

  Fly   240 SVSKRIKVSVDFSPMVW--------IPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITE 296
            | |:.:::||:..|.:.        :|.| |....|..:||:|..:.:|..|..||:::..:...
Human  1055 S-SQEMRLSVNTKPRIHMNGSRNADVPLQ-VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPI 1117

  Fly   297 SSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTT 361
            :::|  ..:|     ..::||  ..||..|.|:|:|.|.||.|.......|.:..||..||.|
Human  1118 TNRY--GLLP-----SGSLRL--AQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGP-- 1171

  Fly   362 TTLRRTTTTAAEIALDGYINTPLNGN----------GIGIVGEGPTNSVIASGKSSIKYLSNLNE 416
                |........|||  :|....||          |:.:.|.||..||         :.:.:..
Human  1172 ----RVLKVLVGEALD--LNCVAEGNPEPQLSWSKDGVVLQGRGPQGSV---------HFAAIRT 1221

  Fly   417 IDKSKQKLTGSSPKGFD-------------WSKGKSSG 441
            .|..:.:...|:..|.|             |...::||
Human  1222 SDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSG 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	31/181 (17%)
		Ig	69..139	CDD:143165	21/153 (14%)
		IG_like	165..249	CDD:214653	23/83 (28%)
		IGc2	172..237	CDD:197706	19/64 (30%)
		IG_like	267..348	CDD:214653	22/80 (28%)
		Ig	270..339	CDD:299845	20/68 (29%)
HMCN2	NP_001278744.1	VWA_2	39..209	CDD:290253
		IG_like	434..513	CDD:214653
		Ig	442..503	CDD:299845
		IG	524..604	CDD:214652
		Ig	534..601	CDD:143165
		I-set	608..692	CDD:254352
		IGc2	621..684	CDD:197706
		IG_like	712..782	CDD:214653	10/46 (22%)
		Ig	715..779	CDD:143165	10/43 (23%)
		Ig	785..869	CDD:299845	14/83 (17%)
		IG	792..879	CDD:214652	12/86 (14%)
		I-set	885..972	CDD:254352	15/87 (17%)
		IGc2	898..962	CDD:197706	10/64 (16%)
		IG	988..1063	CDD:214652	22/77 (29%)
		Ig	995..1062	CDD:299845	20/69 (29%)
		I-set	1079..1161	CDD:254352	26/91 (29%)
		IGc2	1088..1151	CDD:197706	21/71 (30%)
		I-set	1165..1246	CDD:254352	21/97 (22%)
		IGc2	1179..1236	CDD:197706	14/67 (21%)
		IG	1258..1340	CDD:214652	2/2 (100%)
		Ig	1266..1340	CDD:299845
		IG	1354..1433	CDD:214652
		IGc2	1360..1423	CDD:197706
		IG	1446..1527	CDD:214652
		IGc2	1453..1517	CDD:197706
		IG	1540..1620	CDD:214652
		Ig	1540..1620	CDD:299845
		I-set	1632..1716	CDD:254352
		IGc2	1641..1704	CDD:197706
		IG	1727..1807	CDD:214652
		IGc2	1734..1797	CDD:197706
		Ig	1820..1893	CDD:299845
		IG_like	1827..1891	CDD:214653
		I-set	1895..1975	CDD:254352
		Ig	1912..1975	CDD:143165
		I-set	1986..2076	CDD:254352
		IGc2	2001..2066	CDD:197706
		Ig	2079..2169	CDD:299845
		I-set	2080..2167	CDD:254352
		I-set	2171..2261	CDD:254352
		IGc2	2185..2251	CDD:197706
		I-set	2273..2355	CDD:254352
		Ig	2285..2352	CDD:143165
		I-set	2367..2449	CDD:254352
		Ig	2379..2449	CDD:299845
		Ig	2452..2542	CDD:299845
		IG_like	2462..2542	CDD:214653
		IG	2558..2638	CDD:214652
		IGc2	2565..2628	CDD:197706
		IG	2656..2736	CDD:214652
		IGc2	2663..2726	CDD:197706
		IG_like	2770..2847	CDD:214653
		IGc2	2773..2837	CDD:197706
		IG	2862..2942	CDD:214652
		Ig	2868..2942	CDD:299845
		IG_like	2954..3034	CDD:214653
		IGc2	2961..3024	CDD:197706
		I-set	3038..3129	CDD:254352
		IGc2	3056..3119	CDD:197706
		I-set	3133..3221	CDD:254352
		IGc2	3148..3208	CDD:197706
		IG	3234..3318	CDD:214652
		IGc2	3240..3306	CDD:197706
		IG	3329..3410	CDD:214652
IGc2	3336..3400	CDD:197706
IG_like	3424..3499	CDD:214653
IGc2	3430..3489	CDD:197706
I-set	3503..3590	CDD:254352
IGc2	3518..3580	CDD:197706
I-set	3602..3683	CDD:254352
IGc2	3610..3673	CDD:197706
IG	3693..3774	CDD:214652
Ig	3693..3774	CDD:299845
Ig	3777..3859	CDD:299845
IG	3784..3867	CDD:214652
IG_like	3887..3958	CDD:214653
IGc2	3887..3948	CDD:197706
IG	3968..4048	CDD:214652
Ig	3979..4040	CDD:299845
I-set	4052..4139	CDD:254352
IGc2	4065..4129	CDD:197706
I-set	4143..4228	CDD:254352
IGc2	4157..4218	CDD:197706
I-set	4246..4317	CDD:254352
IGc2	4247..4309	CDD:197706
Ig	4322..4405	CDD:299845
I-set	4323..4409	CDD:254352
G2F	4411..4593	CDD:284812
FXa_inhibition	4652..4687	CDD:291342
EGF_CA	4689..4732	CDD:214542
EGF_CA	4733..4774	CDD:284955
EGF_CA	4776..4815	CDD:284955
EGF_CA	4883..4922	CDD:214542
EGF_CA	4923..4963	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910