DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and CADM2

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_016861551.1	Gene:	CADM2 / 253559	HGNCID:	29849	Length:	449	Species:	Homo sapiens

Alignment Length:	452	Identity:	102/452 - (22%)
Similarity:	166/452 - (36%)	Gaps:	119/452 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAYHLEAISSFLYV-GL---GCLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENI 61
            |.:...|:..|..| ||   |..|..|..:....||:|                  :| .:.:|:
Human     1 MIWKRSAVLRFYSVCGLLLQGKHINHSSVIRLHQGSQG------------------QF-PLTQNV 46

  Fly    62 TVPAGRNVKLACSVKNLGSYKVAW-------MHFEQSAILTVHNHVITRNPRISVTHDKHDKHRT 119
            ||..|....|.|.|....:..:.|       ::|:....|        |:.||.:.      ..:
Human    47 TVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKAL--------RDNRIELV------RAS 97

  Fly   120 WF---LHINNVQEEDRGRYMCQINTVTAKTQYGFVKVV-VPPNIDDALTSSDIIVREGDNVTLRC 180
            |.   :.:::|...|.|:|.|.:.|:..||...::.|: ||.....:..||.::  |||.:.|.|
Human    98 WHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVM--EGDLMQLTC 160

  Fly   181 KAKGS-PEPTIKW-------------KRDDGNK--IVINKTLEVHDLETDSLELERISRLHMG-A 228
            |..|| |...|:|             |.:|.|:  ..::.||:.           |:.|...| |
Human   161 KTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDF-----------RVDRSDDGVA 214

  Fly   229 YLCIA---SNGVPPSVSKRIKVSVDFSPMVWI----PHQLVGIPIGFNITLECFIEANP-TSLNY 285
            .:|..   |....|.|:.:: :.:.::|.|.|    |....|.|    :.|.|..:..| .....
Human   215 VICRVDHESLNATPQVAMQV-LEIHYTPSVKIIPSTPFPQEGQP----LILTCESKGKPLPEPVL 274

  Fly   286 WTREN------DQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGN 344
            ||::.      |:|:....:                 |.|..:..:|.|.|:|.|.|..|.....
Human   275 WTKDGGELPDPDRMVVSGRE-----------------LNILFLNKTDNGTYRCEATNTIGQSSAE 322

  Fly   345 IKLYMSSPPTTQPP----PTTTTLRRTTTTAAEIALDGYINTPLNGNGIGIVGE-GPTNSVI 401
            ..|.:...|.|..|    |:.||...|||.|...:......|....:...:.|: ||.:::|
Human   323 YVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALI 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	23/106 (22%)
		Ig	69..139	CDD:143165	15/79 (19%)
		IG_like	165..249	CDD:214653	26/103 (25%)
		IGc2	172..237	CDD:197706	22/84 (26%)
		IG_like	267..348	CDD:214653	16/87 (18%)
		Ig	270..339	CDD:299845	15/75 (20%)
CADM2	XP_016861551.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910