DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and HEPACAM2

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001275733.1	Gene:	HEPACAM2 / 253012	HGNCID:	27364	Length:	485	Species:	Homo sapiens

Alignment Length:	355	Identity:	76/355 - (21%)
Similarity:	122/355 - (34%)	Gaps:	96/355 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGR-----NVKLACSVKNLGSYKVAWMHFEQSA 92
            :|| |.:..|....|..:||....|:: |..|:|.     |:.|.|.|:  |..::|:...:...
Human   150 QGN-GTLSASQKIQVTVDDPVTKPVVQ-IHPPSGAVEYVGNMTLTCHVE--GGTRLAYQWLKNGR 210

  Fly    93 ILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVV-- 155
              .||.         |.|:....::.|  |||..|.:||.|.|.|.:....::.:...:..::
Human   211 --PVHT---------SSTYSFSPQNNT--LHIAPVTKEDIGNYSCLVRNPVSEMESDIIMPIIYY 262

  Fly   156 -----PPNIDDALTSSDII-VREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINK---TLEVHDL 211
                 ..|.|..|...::. |..|:.:...|.|...|..|..|.|...|...|.|   .|||..
Human   263 GPYGLQVNSDKGLKVGEVFTVDLGEAILFDCSADSHPPNTYSWIRRTDNTTYIIKHGPRLEVAS- 326

  Fly   212 ETDSLELERISRLHMGAYLCIASNGV--------------PPSVSKRIKVSVDFSPMVWIPHQLV 262
                   |::::..|. |:|.|.|.:              ...:.|..:.....||:.    .:.
Human   327 -------EKVAQKTMD-YVCCAYNNITGRQDETHFTVIITSVGLEKLAQKGKSLSPLA----SIT 379

  Fly   263 GIPIGFNITLECFIEANPTSLNYWTRENDQMI--------TESSKYKTETIPGH----------- 308
            ||.: |.|...|.       |..|.:.....:        .|:...|.:|..||
Human   380 GISL-FLIISMCL-------LFLWKKYQPYKVIKQKLEGRPETEYRKAQTFSGHEDALDDFGIYE 436

  Fly   309 ----PSYKATMRLTITNVQSSDYGNYKCVA 334
                |......|:...:|.:||     ||:
Human   437 FVAFPDVSGVSRIPSRSVPASD-----CVS 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	23/100 (23%)
		Ig	69..139	CDD:143165	19/69 (28%)
		IG_like	165..249	CDD:214653	21/101 (21%)
		IGc2	172..237	CDD:197706	19/67 (28%)
		IG_like	267..348	CDD:214653	17/91 (19%)
		Ig	270..339	CDD:299845	16/88 (18%)
HEPACAM2	NP_001275733.1	Ig	128..>197	CDD:299845	15/50 (30%)
		I-set	172..255	CDD:254352	24/98 (24%)
		IGc2	190..249	CDD:197706	19/73 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910