DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_766486.1	Gene:	Kirrel2 / 243911	MGIID:	2442334	Length:	700	Species:	Mus musculus

Alignment Length:	606	Identity:	111/606 - (18%)
Similarity:	183/606 - (30%)	Gaps:	234/606 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ISSFLYVGLGCLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLA 72
            ::|.|.|.|.|.             :|:||:            .|.|....|::.|..|...:|.
Mouse     2 LASALLVFLCCF-------------KGHAGS------------SPHFLQQPEDMVVLLGEEARLP 41

  Fly    73 CSVKNLGSYK--VAWMHFEQSAILTVHNHVITRNP-RISVTHDKHDKHRTWF----------LHI 124
            |:   ||:|:  |.|                |::. .:....|.....|.|.          |||
Mouse    42 CA---LGAYRGLVQW----------------TKDGLALGGERDLPGWSRYWISGNSASGQHDLHI 87

  Fly   125 NNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGS--PE 187
            ..|:.||...|.||.:....:::...:.|:|||.....|....:.:..|....|.|:::|.  |.
Mouse    88 KPVELEDEASYECQASQAGLRSRPAQLHVMVPPEAPQVLGGPSVSLVAGVPGNLTCRSRGDSRPA 152

  Fly   188 PTIKWKR----------------------------------DDGNKIV---------------IN 203
            |.:.|.|                                  |||..::               :.
Mouse   153 PELLWFRDGIRLDGSSFHQTTLKDKATGTVENTLFLTPSSHDDGATLICRARSQALPTGRDTAVT 217

  Fly   204 KTLEVHDLETDSLELERISRLHMGAYLCIASNGVPP----------------------------- 239
            .:|:...:.|.|.|.:.:.......:||.|: ..||
Mouse   218 LSLQYPPMVTLSAEPQTVQEGEKVTFLCQAT-AQPPVTGYRWAKGGSPVLGARGPRLEVVADATF 281

  Fly   240 --------------SVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTREN 290
                          |.::...:.|.:.|::....:.|.:.:|.:.:..|....||.....|||..
Mouse   282 LTEPVSCEVSNAVGSANRSTALEVLYGPILQAKPKSVSVDVGKDASFSCVWRGNPLPRITWTRMG 346

  Fly   291 DQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDG---NIKLYMSSP 352
            ...:..|.              .|:||  .:|...|.|:|.|.|:..|..:.|   ..:|.:::|
Mouse   347 GSQVLSSG--------------PTLRL--PSVALEDAGDYVCRAEPRRTGLGGGKAQARLTVNAP 395

  Fly   353 PTT---QPPPT--TTTLRRTTTTAAEIALDGYI----NTPLNGNGIG--IV----------GEGP 396
            |..   ||.|.  ....|......|..|.|..:    ...|....:|  :|          |:||
Mouse   396 PVVTALQPAPAFLRGPARLQCVVFASPAPDSVVWSWDEGFLEAGSLGRFLVEAFPAPEVEGGQGP 460

  Fly   397 TNSVIASGKSSIKYLSNLNEIDKSKQKLTGSSPKGFDWS-------------------------- 435
                   |..|:.::|...|.|.:         .||:.|
Mouse   461 -------GLISVLHISGTQESDFT---------TGFNCSARNRLGEGRVQIHLGRRDLLPTVRIV 509

  Fly   436 KGKSSGSHGNLMASSWPLICC 456
            .|.:|.:...||..:..::||
Mouse   510 AGAASAATSLLMVITGVVLCC 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/108 (22%)
		Ig	69..139	CDD:143165	19/82 (23%)
		IG_like	165..249	CDD:214653	21/177 (12%)
		IGc2	172..237	CDD:197706	18/115 (16%)
		IG_like	267..348	CDD:214653	19/83 (23%)
		Ig	270..339	CDD:299845	16/68 (24%)
Kirrel2	NP_766486.1	IG	27..116	CDD:214652	23/107 (21%)
		Ig	122..220	CDD:416386	12/97 (12%)
		Ig strand A	123..126	CDD:409353	0/2 (0%)
		Ig strand A'	129..133	CDD:409353	0/3 (0%)
		Ig strand B	140..147	CDD:409353	2/6 (33%)
		Cell attachment site. /evidence=ECO:0000255	146..148		0/1 (0%)
		Ig strand C	153..158	CDD:409353	1/4 (25%)
		Ig strand C'	161..163	CDD:409353	0/1 (0%)
		Ig strand D	166..173	CDD:409353	0/6 (0%)
		Ig strand E	180..188	CDD:409353	0/7 (0%)
		Ig strand F	197..205	CDD:409353	0/7 (0%)
		Ig strand G	211..217	CDD:409353	0/5 (0%)
		Ig_3	223..292	CDD:404760	8/69 (12%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	255..259	CDD:409353	0/3 (0%)
		Ig strand E	272..275	CDD:409353	0/2 (0%)
		Ig strand F	281..290	CDD:409353	0/8 (0%)
		Ig strand G	298..301	CDD:409353	0/2 (0%)
		Ig	315..392	CDD:416386	21/92 (23%)
		Ig strand A'	316..321	CDD:409353	1/4 (25%)
		Ig strand B	324..333	CDD:409353	1/8 (13%)
		Ig strand C	339..343	CDD:409353	0/3 (0%)
		Ig strand C'	346..348	CDD:409353	0/1 (0%)
		Ig strand D	351..354	CDD:409353	0/2 (0%)
		Ig strand E	355..360	CDD:409353	3/6 (50%)
		Ig strand F	368..376	CDD:409353	4/7 (57%)
		Ig strand G	382..392	CDD:409353	2/9 (22%)
		Ig	394..498	CDD:416386	23/119 (19%)
		Ig strand A	395..399	CDD:409353	2/3 (67%)
		Ig strand A'	401..404	CDD:409353	1/2 (50%)
		Ig strand B	412..419	CDD:409353	1/6 (17%)
		Ig strand C	426..431	CDD:409353	0/4 (0%)
		Ig strand C'	433..436	CDD:409353	0/2 (0%)
		Ig strand D	444..451	CDD:409353	1/6 (17%)
		Ig strand E	461..468	CDD:409353	2/6 (33%)
		Ig strand F	479..486	CDD:409353	3/6 (50%)
		Ig strand G	489..496	CDD:409353	0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810