DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-epsilon and Siglec1

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_036015809.1	Gene:	Siglec1 / 20612	MGIID:	99668	Length:	1719	Species:	Mus musculus

Alignment Length:	418	Identity:	91/418 - (21%)
Similarity:	143/418 - (34%)	Gaps:	127/418 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 STLNNVISEDPEFTDVIENITVPAGRN------VKLACSVKNLGSY----KVAWMHFEQSAILTV 96
            |:...|..:.|.....:|.:...:|||      |.|.|.|.:  ||    .|.|.  .....|.|
Mouse   232 SSRKEVYLQVPHAPKGVEILLSSSGRNILPGDPVTLTCRVNS--SYPAVSAVQWA--RDGVNLGV 292

  Fly    97 HNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDD 161
            ..||                     |.:.:....|.|.|.||     |....|
Mouse   293 TGHV---------------------LRLFSAAWNDSGAYTCQ-----ATNDMG------------ 319

  Fly   162 ALTSSDII---------------VREGDNVTLRCKA-KGSP-EPTIKWKRDDGNKIVINKTLEVH 209
            :|.||.:.               |.|.:.|||.|.. |.:| |....|.:   |.|::      .
Mouse   320 SLVSSPLSLHVFMAEVKMNPAGPVLENETVTLLCSTPKEAPQELRYSWYK---NHILL------E 375

  Fly   210 DLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPM-----VWIPHQ--LVGIPIG 267
            |....:|.|..::|...|.|.|...|......|..:.|.|.:.|:     .::..|  ||||
Mouse   376 DAHASTLHLPAVTRADTGFYFCEVQNAQGSERSSPLSVVVRYPPLTPDLTTFLETQAGLVGI--- 437

  Fly   268 FNITLECFIEANP----------TSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNV 322
                |.|.:.:.|          .:|...:.|||    .:.:::..:.|.      ::||.|.::
Mouse   438 ----LHCSVVSEPLATVVLSHGGLTLASNSGEND----FNPRFRISSAPN------SLRLEIRDL 488

  Fly   323 QSSDYGNYKCVAKNPRGDMDGNIKLYMS--------SPPTTQPPPTTTTLRRTTTTAAEIALDGY 379
            |.:|.|.|.|:|.|..|:...::..|.:        |....:....|.:.|...:.|.:.....|
Mouse   489 QPADSGEYTCLAVNSLGNSTSSLDFYANVARLLINPSAEVVEGQAVTLSCRSGLSPAPDTRFSWY 553

  Fly   380 INTPLNGNGIGIVGEGPTNSVIASGKSS 407
            :|..|       :.||.::|::....||
Mouse   554 LNGAL-------LLEGSSSSLLLPAASS 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/105 (23%)
		Ig	69..139	CDD:143165	17/73 (23%)
		IG_like	165..249	CDD:214653	24/100 (24%)
		IGc2	172..237	CDD:197706	19/66 (29%)
		IG_like	267..348	CDD:214653	19/90 (21%)
		Ig	270..339	CDD:299845	18/78 (23%)
Siglec1	XP_036015809.1	IgV_CD33	27..134	CDD:409377
		Ig strand B	43..47	CDD:409377
		Ig strand C	62..66	CDD:409377
		Ig strand E	104..108	CDD:409377
		Ig strand F	118..123	CDD:409377
		C2-set_2	148..235	CDD:400489	1/2 (50%)
		Ig strand A	148..153	CDD:409353
		Ig strand B	161..169	CDD:409353
		Ig strand C	178..184	CDD:409353
		Ig strand D	193..199	CDD:409353
		Ig strand E	203..212	CDD:409353
		Ig strand G	231..239	CDD:409353	2/6 (33%)
		Ig strand A	245..253	CDD:409353	1/7 (14%)
		Ig strand A'	257..261	CDD:409353	2/3 (67%)
		IGc2	261..319	CDD:197706	19/87 (22%)
		Ig strand B	262..272	CDD:409353	3/9 (33%)
		Ig strand C	279..285	CDD:409353	2/7 (29%)
		Ig strand C'	287..290	CDD:409353	0/2 (0%)
		Ig strand E	296..301	CDD:409353	2/25 (8%)
		Ig strand F	308..316	CDD:409353	5/12 (42%)
		Ig strand G	319..330	CDD:409353	4/22 (18%)
		Ig	334..417	CDD:416386	23/91 (25%)
		Ig strand A'	342..345	CDD:409353	1/2 (50%)
		Ig strand B	346..356	CDD:409353	4/9 (44%)
		Ig strand C	363..369	CDD:409353	1/5 (20%)
		Ig strand C'	371..374	CDD:409353	1/2 (50%)
		Ig strand E	380..386	CDD:409353	2/5 (40%)
		Ig strand F	393..401	CDD:409353	3/7 (43%)
		Ig strand G	404..417	CDD:409353	3/12 (25%)
		Ig strand A'	412..415	CDD:409353	1/2 (50%)
		Ig	428..511	CDD:416386	24/99 (24%)
		Ig strand B	436..443	CDD:409353	4/13 (31%)
		Ig strand C	449..454	CDD:409353	0/4 (0%)
		Ig strand C'	456..458	CDD:409353	0/1 (0%)
		Ig strand D	471..477	CDD:409353	0/5 (0%)
		Ig strand E	480..486	CDD:409353	2/5 (40%)
		Ig strand F	494..502	CDD:409353	4/7 (57%)
		Ig_3	523..583	CDD:404760	12/59 (20%)
		IG	624..702	CDD:214652
		Ig_3	712..777	CDD:404760
		Ig strand A'	720..723	CDD:409353
		Ig strand B	724..734	CDD:409353
		Ig strand C	742..748	CDD:409353
		Ig strand C'	750..753	CDD:409353
		Ig strand E	759..765	CDD:409353
		Ig strand F	772..780	CDD:409353
		Ig strand G	783..796	CDD:409353
		Ig	815..895	CDD:416386
		Ig strand B	815..819	CDD:409353
		Ig strand C	828..832	CDD:409353
		Ig strand E	861..865	CDD:409353
		Ig strand F	875..880	CDD:409353
		Ig	900..975	CDD:416386
		Ig strand A'	907..910	CDD:409353
		Ig strand B	911..921	CDD:409353
		Ig strand C	928..934	CDD:409353
		Ig strand C'	936..939	CDD:409353
		Ig strand E	945..951	CDD:409353
		Ig strand F	958..968	CDD:409353
		Ig strand G	971..984	CDD:409353
		IG_like	1005..1093	CDD:214653
		Ig strand C	1026..1031	CDD:409353
		Ig strand C'	1033..1035	CDD:409353
		Ig strand D	1042..1048	CDD:409353
Ig strand E	1051..1057	CDD:409353
Ig strand F	1065..1073	CDD:409353
Ig_2	1095..1167	CDD:404734
Ig strand A'	1095..1100	CDD:409353
Ig strand B	1105..1114	CDD:409353
Ig strand C	1121..1126	CDD:409353
Ig strand C'	1128..1131	CDD:409353
Ig strand E	1133..1138	CDD:409353
Ig strand F	1148..1156	CDD:409353
Ig strand G	1160..1170	CDD:409353
IG_like	1195..1258	CDD:214653
Ig strand C	1204..1208	CDD:409353
Ig strand E	1226..1230	CDD:409353
Ig strand F	1240..1245	CDD:409353
Ig	1265..1344	CDD:416386
Ig strand A'	1271..1274	CDD:409353
Ig strand B	1278..1284	CDD:409353
Ig strand C	1294..1299	CDD:409353
Ig strand C'	1301..1303	CDD:409353
Ig strand E	1309..1314	CDD:409353
Ig strand F	1322..1327	CDD:409353
Ig strand G	1338..1344	CDD:409353
Ig	<1365..1440	CDD:416386
Ig strand B	1365..1372	CDD:409353
Ig strand C	1378..1383	CDD:409353
Ig strand C'	1386..1388	CDD:409353
Ig strand D	1394..1407	CDD:409353
Ig strand E	1409..1415	CDD:409353
Ig strand F	1424..1432	CDD:409353
Ig_3	1450..1517	CDD:404760
Ig strand B	1555..1561	CDD:409353
Ig	<1556..1630	CDD:416386
Ig strand C	1566..1571	CDD:409353
Ig strand C'	1573..1575	CDD:409353
Ig strand D	1592..1596	CDD:409353
Ig strand E	1599..1603	CDD:409353
Ig strand F	1613..1621	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910