DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Musk

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001032204.2	Gene:	Musk / 18198	MGIID:	103581	Length:	893	Species:	Mus musculus

Alignment Length:	326	Identity:	75/326 - (23%)
Similarity:	128/326 - (39%)	Gaps:	53/326 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PEFTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITR--NPRISVTHDKH 114
            |..|..:|.:...........|:|::....:::|          ..|.::.:  :.|.|:
Mouse    28 PVITTPLETVDALVEEVATFMCAVESYPQPEISW----------TRNKILIKLFDTRYSI----- 77

  Fly   115 DKHRTWFLHINNVQEEDRGRYMCQINTVT--AKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVT 177
             :.....|.|.:|::.|.|.|.|..|...  |....|.::|.:.|.|.....:..||  ||....
Mouse    78 -RENGQLLTILSVEDSDDGIYCCIANNGVGGAVESCGALQVKMKPKITRPPINVKII--EGLKAV 139

  Fly   178 LRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVS 242
            |.|...|:|:|::.|.:.| |.:..|..:.|  ||:.||.:..:.:...|.|.|:|.|.:..:.|
Mouse   140 LPCTTMGNPKPSVSWIKGD-NALRENSRIAV--LESGSLRIHNVQKEDAGQYRCVAKNSLGTAYS 201

  Fly   243 KRIKVSVD-----------FSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITE 296
            |.:|:.|:           |:.::..| :...:..|..:||.|.....|.....|. ||...::.
Mouse   202 KLVKLEVEEDREPEQDAKVFARILRAP-ESHNVTFGSFVTLRCTAIGIPVPTISWI-ENGNAVSS 264

  Fly   297 SS---KYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPP 358
            .|   ..|...|      .:.::|.||..     |.|.|:|.|..|:.....|. .::.....||
Mouse   265 GSIQESVKDRVI------DSRLQLFITKP-----GLYTCIATNKHGEKFSTAKA-AATVSIAVPP 317

  Fly   359 P 359
            |
Mouse   318 P 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	18/99 (18%)
		Ig	69..139	CDD:143165	13/71 (18%)
		IG_like	165..249	CDD:214653	26/83 (31%)
		IGc2	172..237	CDD:197706	21/64 (33%)
		IG_like	267..348	CDD:214653	21/83 (25%)
		Ig	270..339	CDD:299845	18/71 (25%)
Musk	NP_001032204.2	I-set	28..117	CDD:254352	19/104 (18%)
		Ig	36..117	CDD:299845	16/96 (17%)
		I-set	121..208	CDD:254352	28/91 (31%)
		Ig	135..201	CDD:299845	20/68 (29%)
		I-set	223..306	CDD:254352	21/95 (22%)
		Ig	239..306	CDD:143165	19/78 (24%)
		CRD_TK_ROR_related	338..482	CDD:143578
		PTKc_Musk	593..882	CDD:133181
		Pkinase_Tyr	599..880	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910