DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and wrk-1

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001024651.1	Gene:	wrk-1 / 181093	WormBaseID:	WBGene00006942	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	337	Identity:	74/337 - (21%)
Similarity:	130/337 - (38%)	Gaps:	88/337 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 ALTSSDI-------IVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVH-------DLE 212
            |.||:.|       |.:||:::||||:.: .|...|.|:::.....|.::.|:.:       :..
Worm    14 ASTSAQIRTKGGTLIAKEGESLTLRCEVE-DPSVAIIWRKNTEVVAVDDEILDTYGGYEISMEGS 77

  Fly   213 TDSLELERISRLHMGAYLCIASNGVPPSVS----------KRIKVSVD----FSPMVWIPHQLVG 263
            |..|.::|:..::...|.|..:.   |.||          |..:|||.    .||...:.|..||
Worm    78 TSVLTIKRVEPINSANYSCALAE---PEVSVTFVIKVQVFKPTQVSVKPLVVISPDTGVYHARVG 139

  Fly   264 IPIGFNITLECFI-EANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDY 327
            ..   |:.:.|.: |.||.....||:       :::|...:....|    ...|:.||.|:....
Worm   140 EK---NLVITCHVKEGNPKPGVVWTK-------QAAKLPEDIKREH----GGARIVITEVKKHHA 190

  Fly   328 GNYKCVAKNPRGDMDGNIKLYMSSP--------PTTQPPPTTTTLRRTTTTAAEIALDGYINTPL 384
            |.|.|:|:|..|.....|.::::.|        |..:...|...:|:....:.....||   ||:
Worm   191 GKYNCLAENIAGSDRATIDIHVAEPLQGEREEKPWVKNEDTFIPVRKNQNASFWCTYDG---TPV 252

  Fly   385 NGNGIGIVGEGPTNSVIASGKSSIKYLSNLNE-----IDKSKQKLTGSSPKGFDWSKGKSSGSHG 444
                       |....:.:|     |..|.|:     ..::.|:|.|.|         ||:.:.|
Worm   253 -----------PQVEWLFNG-----YKINFNDEKFKKTSETAQRLNGYS---------KSTLTVG 292

  Fly   445 NLMASSWPLICC 456
            ::...::....|
Worm   293 DISEEAFGDYAC 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653
		Ig	69..139	CDD:143165
		IG_like	165..249	CDD:214653	24/107 (22%)
		IGc2	172..237	CDD:197706	16/71 (23%)
		IG_like	267..348	CDD:214653	20/81 (25%)
		Ig	270..339	CDD:299845	17/69 (25%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	20/91 (22%)
		IGc2	31..96	CDD:197706	15/65 (23%)
		IG_like	132..212	CDD:214653	23/93 (25%)
		IGc2	142..202	CDD:197706	18/70 (26%)
		IG_like	235..320	CDD:214653	18/98 (18%)
		Ig	245..318	CDD:143165	17/88 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910