DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and sma-10

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	448	Identity:	83/448 - (18%)
Similarity:	142/448 - (31%)	Gaps:	158/448 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 GRNVKLACSVKNLGSYKVAWMHFE--QSAILTVHNHV---ITRNPRISVTHDKHDKHRTWFLHIN 125
            |...:..|:|.......:.|...|  |..:|...:..   |.|...::.|.|:.:......| ::
Worm   519 GEKARFTCNVYGASPLSIEWRVMENGQPRVLVQDSATFLSINRTAVVNGTFDERELAAAELL-LD 582

  Fly   126 NVQEEDRGRYMCQINTVTAKTQYG-----FVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGS 185
            ||...|...|.|     .|:.::|     .||:.|........|..|:.:..|......|.|.|:
Worm   583 NVAMTDNSEYQC-----VARNRFGSDFSTHVKLQVYQAPKFTYTPEDMPLLVGQTAKFLCAATGT 642

  Fly   186 PEPTIKWKRD-------DGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGV------ 237
            |.|.|||..:       :..::.:..       ..|.:.:..:::...|||.|.|:|..
Worm   643 PRPEIKWAFEQIPFPAAEARRLYVTP-------NDDHIYIMNVTKEDQGAYTCHATNVAGQTQAS 700

  Fly   238 -------------------PPSVSKRIKVSVDFS--------PMVWIPHQLVGIPIGFNITLECF 275
                               |..:.||..:.:|.|        .|||...|.|.:          |
Worm   701 ANLIVFENFFHYPESPDLSPMLIKKRDALKIDCSCDLISSRQRMVWKRQQQVIL----------F 755

  Fly   276 IEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGD 340
            ::....|      :|||:                       ||:|....||.|.|.|
Worm   756 LKKAKFS------DNDQI-----------------------LTLTQTTFSDSGEYSC-------- 783

  Fly   341 MDGNIKLYMSSPPTTQPPPTTTTLRRTTTTAAEIALDGYINTPLNGNGIGIVGEGPTNSVIASGK 405
                 :|::..         |..:|:.|.                   :.:|.|.
Worm   784 -----ELWVDD---------TILMRKITM-------------------VKVVNED---------- 805

  Fly   406 SSIKYLSNLNEIDKSKQKLTGSSPKGFDWSKGKSSGSHGNLMASSWPLICCILALLTT 463
               :::|:...:.:..|::...:.|..|  ..||:|:...||||.......||.::|:
Worm   806 ---EFVSSEATLTQRVQRIRAMASKLVD--NIKSTGNGIYLMASCSAFGLMILGVITS 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	21/98 (21%)
		Ig	69..139	CDD:143165	16/74 (22%)
		IG_like	165..249	CDD:214653	20/115 (17%)
		IGc2	172..237	CDD:197706	16/71 (23%)
		IG_like	267..348	CDD:214653	13/80 (16%)
		Ig	270..339	CDD:299845	13/68 (19%)
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470
		leucine-rich repeat	55..77	CDD:275380
		LRR_8	78..135	CDD:290566
		LRR_4	78..116	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		LRR_RI	100..303	CDD:238064
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		LRR_8	172..231	CDD:290566
		leucine-rich repeat	173..196	CDD:275380
		leucine-rich repeat	197..220	CDD:275380
		leucine-rich repeat	221..244	CDD:275380
		LRR_8	243..303	CDD:290566
		leucine-rich repeat	245..268	CDD:275380
		LRR_RI	269..453	CDD:238064
		leucine-rich repeat	269..292	CDD:275380
		leucine-rich repeat	293..316	CDD:275380
		LRR_8	315..373	CDD:290566
		leucine-rich repeat	317..340	CDD:275380
		leucine-rich repeat	341..364	CDD:275380
		leucine-rich repeat	365..392	CDD:275380
		LRR_8	393..450	CDD:290566
		leucine-rich repeat	393..416	CDD:275380
		leucine-rich repeat	417..438	CDD:275380
		I-set	506..612	CDD:254352	21/98 (21%)
		Ig	522..606	CDD:143165	18/89 (20%)
		I-set	616..705	CDD:254352	18/95 (19%)
		Ig	633..705	CDD:299845	15/78 (19%)
		Ig	716..786	CDD:299845	23/121 (19%)
		IG	719..788	CDD:214652	24/120 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910