DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Mag

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001333013.1	Gene:	Mag / 17136	MGIID:	96912	Length:	627	Species:	Mus musculus

Alignment Length:	347	Identity:	88/347 - (25%)
Similarity:	150/347 - (43%)	Gaps:	63/347 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VGL-GCLIASSVALSTDTGSEGN-AGNVGGSTLNNVISEDPEFTDVIE--NITVP----AGRNVK 70
            :|| .|.:..| .||.:.|.:.. .|::||  .|.....:....|::.  ||.||    ||..|:
Mouse    95 LGLRNCTLLLS-TLSPELGGKYYFRGDLGG--YNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVE 156

  Fly    71 LACSV-KNLGSYK--VAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTW----FLHINNVQ 128
            ::|.| .|....:  ::|:..|.....||...:             .:...||    .||....:
Mouse   157 VSCMVPDNCPELRPELSWLGHEGLGEPTVLGRL-------------REDEGTWVQVSLLHFVPTR 208

  Fly   129 EEDRGRYMCQI---NTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTI 190
            |.:..|..||.   ||......|..:.|..||.|.:..:|.:.|  ||.:|:|.|.|..:|.|.:
Mouse   209 EANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAI--EGSHVSLLCGADSNPPPLL 271

  Fly   191 KWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMV 255
            .|.||.   :|:.:.:    .::..|:||.::....|.|.|:|.|..... ::.:::||.::|
Mouse   272 TWMRDG---MVLREAV----AKSLYLDLEEVTPGEDGVYACLAENAYGQD-NRTVELSVMYAP-- 326

  Fly   256 WIP---HQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRL 317
            |.|   ..:|.:. |..:::.|..::||          |.::|   .:|.:.|.....|::.::|
Mouse   327 WKPTVNGTVVAVE-GETVSILCSTQSNP----------DPILT---IFKEKQILATVIYESQLQL 377

  Fly   318 TITNVQSSDYGNYKCVAKNPRG 339
            .:..|...|.|.|.|||:|..|
Mouse   378 ELPAVTPEDDGEYWCVAENQYG 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	26/111 (23%)
		Ig	69..139	CDD:143165	15/76 (20%)
		IG_like	165..249	CDD:214653	22/83 (27%)
		IGc2	172..237	CDD:197706	20/64 (31%)
		IG_like	267..348	CDD:214653	19/73 (26%)
		Ig	270..339	CDD:299845	17/68 (25%)
Mag	NP_001333013.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		65/255 (25%)
		IgV_CD33	22..137	CDD:409377	11/44 (25%)
		Ig strand B	38..42	CDD:409377
		Ig strand C	56..60	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	65..67
		Ig strand E	100..104	CDD:409377	1/3 (33%)
		Ig strand F	114..119	CDD:409377	0/4 (0%)
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	124..128		1/3 (33%)
		Ig strand G	128..133	CDD:409377	0/4 (0%)
		IgC2_CD33_d2_like	141..235	CDD:409579	25/106 (24%)
		Ig strand B	155..159	CDD:409579	1/3 (33%)
		Ig strand C	171..175	CDD:409579	0/3 (0%)
		Ig strand E	200..204	CDD:409579	1/3 (33%)
		Ig strand F	214..219	CDD:409579	2/4 (50%)
		Ig strand G	229..232	CDD:409579	0/2 (0%)
		Ig_3	239..309	CDD:404760	24/78 (31%)
		Ig strand A	239..242	CDD:409353	2/2 (100%)
		Ig strand A'	248..251	CDD:409353	1/2 (50%)
		Ig strand B	256..264	CDD:409353	3/7 (43%)
		Ig strand C	270..274	CDD:409353	0/3 (0%)
		Ig strand C'	277..280	CDD:409353	0/5 (0%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	4/7 (57%)
		Ig strand G	312..322	CDD:409353	0/10 (0%)
		IG	333..409	CDD:214652	20/81 (25%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000269\|PubMed:9482783	578..627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910