DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Papln

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001192272.1	Gene:	Papln / 170721	MGIID:	2386139	Length:	1302	Species:	Mus musculus

Alignment Length:	199	Identity:	46/199 - (23%)
Similarity:	74/199 - (37%)	Gaps:	65/199 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 PNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETD-SLELER 220
            |.:.||        ..|..:.|.|:|:|.|.|||:|:||  .::|.:..   |.::.| ||.:.|
Mouse  1072 PGVVDA--------SPGQRIRLTCRAEGFPVPTIEWQRD--GQLVSSPR---HQVQPDGSLVISR 1123

  Fly   221 ISRLHMGAYLCIASN--------------------GVPPSVSKRIKVSVDFSPMVWIPHQLVGIP 265
            :.....|.|.|:|.|                    |:||:|:                     :.
Mouse  1124 VDVEDGGYYSCVAFNGQDRDQRWVQLRVLRELTITGLPPAVT---------------------VA 1167

  Fly   266 IGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNY 330
            .|....|.|.:.....::. |:|....:..:..:.       |.|...|  |.|.|::..|.|:|
Mouse  1168 EGDTARLLCVVAGESVNIR-WSRNGLPIQADGHRV-------HQSPDGT--LLIHNLRPRDEGSY 1222

  Fly   331 KCVA 334
            .|.|
Mouse  1223 TCSA 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653
		Ig	69..139	CDD:143165
		IG_like	165..249	CDD:214653	27/104 (26%)
		IGc2	172..237	CDD:197706	23/85 (27%)
		IG_like	267..348	CDD:214653	16/68 (24%)
		Ig	270..339	CDD:299845	15/65 (23%)
Papln	NP_001192272.1	TSP1	30..81	CDD:214559
		ADAM_spacer1	184..299	CDD:368694
		TSP1	309..362	CDD:214559
		TSP1	389..447	CDD:214559
		TSP1	447..504	CDD:214559
		TSP1	511..562	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..737
		Kunitz_BPTI	771..822	CDD:333766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..924
		Papilin_u7	831..922	CDD:374683
		Ig	932..>995	CDD:386229
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1024..1064
		I-set	1070..1141	CDD:369462	26/81 (32%)
		Ig	1157..1241	CDD:386229	20/101 (20%)
		PLAC	1257..1289	CDD:370061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900