DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and AgaP_AGAP005219

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_314120.4	Gene:	AgaP_AGAP005219 / 1274926	VectorBaseID:	AGAP005219	Length:	1847	Species:	Anopheles gambiae

Alignment Length:	436	Identity:	97/436 - (22%)
Similarity:	160/436 - (36%)	Gaps:	117/436 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SSVALSTDTGS-----------EGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLACSV 75
            |.|.:.|.||.           :.|..|:..||....:||          :....|.:|:|.|:|
Mosquito   218 SCVTVDTLTGERKTSEAILLTLKDNIPNMAPSTSQKSVSE----------LKAGKGASVQLPCNV 272

  Fly    76 KNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQIN 140
            :.......:|.....:..|    :.:..:.||..:..        .|.|.||.|.|.||::|:
Mosquito   273 QGNPVPSFSWFRISDTGSL----YTVPSSQRIVPSQS--------LLFIRNVDERDAGRWICK-- 323

  Fly   141 TVTAKTQYGFVKVVVPPNIDDALTS----SDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIV 201
               |..|:|..|:.:...|.:.|.:    ...|:..|::..|.|...||....|:|.. :|.::.
Mosquito   324 ---AFNQFGEQKLEIHLTISNELVAHIHPQIQIINSGNSALLNCSIYGSEVNKIEWFH-NGQELF 384

  Fly   202 INKTLEVHDLETDSLELERISRLHMGAYLCIASNG--------------VPPSVS-----KRIKV 247
            .|...|...|..::|:::|:|:...|.|.||.||.              .||.:|     :.::.
Mosquito   385 ANGRSERSLLSANTLKIDRVSKKDQGIYQCIVSNARSSAQGSSELKLGESPPEISYGFVEQNVRA 449

  Fly   248 SVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESS--KYKTE---TIPG 307
            |.                   .|:|:|....:|.....|..:...::..||  :|..:   .|..
Mosquito   450 SA-------------------YISLKCSAAGSPPPQFVWLLDYQPILDVSSLHRYTMDQFLDINS 495

  Fly   308 HPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTTAA 372
            |    .|..|.|::|.|.|.|.|.|||.|..|......:|.:..||..:      .:...|..|.
Mosquito   496 H----VTTHLNISHVHSDDGGLYTCVASNSMGTASHKARLNVYGPPYVR------AIGPITAVAG 550

  Fly   373 E-IALDGYINTPLNGNGIGIVGEGPTNSVIASGKSSIKYLSNLNEI 417
            | |.|    :.|.:|:.|                .|::::...||:
Mosquito   551 EPIEL----HCPFSGHPI----------------QSVRWIRGGNEL 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	22/95 (23%)
		Ig	69..139	CDD:143165	17/69 (25%)
		IG_like	165..249	CDD:214653	24/106 (23%)
		IGc2	172..237	CDD:197706	20/78 (26%)
		IG_like	267..348	CDD:214653	23/85 (27%)
		Ig	270..339	CDD:299845	22/73 (30%)
AgaP_AGAP005219	XP_314120.4	Ig	41..>97	CDD:299845
		IGc2	263..329	CDD:197706	20/82 (24%)
		IG_like	349..430	CDD:214653	21/81 (26%)
		IGc2	356..419	CDD:197706	19/63 (30%)
		Ig	453..530	CDD:143165	23/80 (29%)
		IG_like	543..627	CDD:214653	11/54 (20%)
		IGc2	550..616	CDD:197706	9/47 (19%)
		IG_like	643..721	CDD:214653
		Ig	648..718	CDD:143165
		Ig	724..800	CDD:299845
		I-set	778..871	CDD:254352
		Ig	796..878	CDD:299845
		FN3	875..998	CDD:238020
		FN3	1005..1108	CDD:238020
		fn3	1116..1203	CDD:278470
		FN3	1215..1311	CDD:238020
		Ig	1316..1394	CDD:299845
		IG_like	1323..1395	CDD:214653
		FN3	1406..1495	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810