DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and AgaP_AGAP003235

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_312941.4	Gene:	AgaP_AGAP003235 / 1273907	VectorBaseID:	AGAP003235	Length:	417	Species:	Anopheles gambiae

Alignment Length:	326	Identity:	131/326 - (40%)
Similarity:	182/326 - (55%)	Gaps:	34/326 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DPEFTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHD 115
            :|||...|:||:.|.||...|.|||||||.|||.|:......:|.:...|:|.|.||||.   |:
Mosquito    18 EPEFEGTIQNISSPTGREAILTCSVKNLGRYKVGWLRASDQTVLALQGRVVTHNSRISVV---HE 79

  Fly   116 KHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRC 180
            ..|||.|.|..::|.|||.||||||....|.|.|.:.|.|||:|.:..:|:||.|:||::.|:.|
Mosquito    80 DFRTWRLRIRQLRESDRGCYMCQINASPMKKQIGCIDVQVPPDIINEESSADIAVQEGEDATIVC 144

  Fly   181 KAKGSPEPTIKWKRDDGNKIVINK-----TLEVHDLETDSLELERISRLHMGAYLCIASNGVPPS 240
            ||.|.|.|.:.|||:||..:::.|     .:.|.......|.|.::.|..||||||||||.|||:
Mosquito   145 KAVGHPTPRVTWKREDGEYMLLRKPQSRELIRVEAYNGTHLHLPKLERRQMGAYLCIASNDVPPA 209

  Fly   241 VSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTR----------------- 288
            ||||:.:||.|:|.|....||:|.|:|.::.|||.:||:|..::||.:
Mosquito   210 VSKRVSLSVHFAPSVRPTSQLLGAPLGSDVQLECTVEASPMPVSYWLKGGRVLPNSFAGAANGNY 274

  Fly   289 -----ENDQMITESSKYK-TETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKL 347
                 ...:|:.:..||. ||...|   ::..|||.:.:...:|.|.|.||:.|..|..||.::|
Mosquito   275 EQPGLSRPEMLLDGPKYGITEDRHG---FRTNMRLVVRSFSPADVGTYHCVSTNSLGRADGTMRL 336

  Fly   348 Y 348
            |
Mosquito   337 Y 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	45/95 (47%)
		Ig	69..139	CDD:143165	33/69 (48%)
		IG_like	165..249	CDD:214653	40/88 (45%)
		IGc2	172..237	CDD:197706	29/69 (42%)
		IG_like	267..348	CDD:214653	27/103 (26%)
		Ig	270..339	CDD:299845	23/91 (25%)
AgaP_AGAP003235	XP_312941.4	Ig	26..109	CDD:299845	41/85 (48%)
		IG_like	33..119	CDD:214653	42/88 (48%)
		IG_like	129..218	CDD:214653	40/88 (45%)
		Ig	140..206	CDD:299845	27/65 (42%)
		IG_like	233..337	CDD:214653	28/106 (26%)
		IGc2	236..328	CDD:197706	24/94 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG29277
OrthoDB	1	1.010	-	-		D102261at50557
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X97
TreeFam	0	0.000	Not matched by this tool.
	6	5.830