DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and AgaP_AGAP002628

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_312298.5	Gene:	AgaP_AGAP002628 / 1273332	VectorBaseID:	AGAP002628	Length:	417	Species:	Anopheles gambiae

Alignment Length:	322	Identity:	88/322 - (27%)
Similarity:	138/322 - (42%)	Gaps:	30/322 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 AGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHV 100
            ||......||..   :|.|....|......|..:.|.|.|.:.|:|.:||.  ...||||..:..
Mosquito     4 AGEAASQILNKA---EPLFISRSEAFKFAVGDTITLPCEVASPGTYVLAWK--RGIAILTAGSVK 63

  Fly   101 ITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTS 165
            :|.:||:.:.:.       :.|.|.:...:|.|.|:|||..:..:.....|:::|||.|....:.
Mosquito    64 VTPDPRVRLVNG-------YSLQIRDAVPQDAGDYICQIAMLDPREITHSVEILVPPKITHVTSG 121

  Fly   166 SDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYL 230
            ..:.||:|..|.|.|.|.|:|.|.|.|.|.  |.::.|..   .........:|.:.|...|.|:
Mosquito   122 GHLQVRKGSPVRLECSATGNPMPNITWTRK--NNLLPNGE---EQFTNPVYVIENMDRHKGGTYI 181

  Fly   231 CIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFI--EANPTSLNYWTRENDQM 293
            |.|:|||....:.:|.:.|.:.|.:.:.:..|....|....|.|.:  |:.|..|  |.::..|
Mosquito   182 CTANNGVGQVATSQIILHVLYPPEISVENPTVYSGEGQEAMLVCIVHGESQPEVL--WHKDTMQ- 243

  Fly   294 ITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTT 355
            |.::.::..|      :..|...|.|..|...|:|||.|:|.|..|.....:.|  :..|.|
Mosquito   244 IDQTERHVIE------NRGARHTLIIRKVHPQDFGNYSCIADNQLGKTRKTVTL--TGKPKT 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	25/95 (26%)
		Ig	69..139	CDD:143165	20/69 (29%)
		IG_like	165..249	CDD:214653	25/83 (30%)
		IGc2	172..237	CDD:197706	20/64 (31%)
		IG_like	267..348	CDD:214653	22/82 (27%)
		Ig	270..339	CDD:299845	20/70 (29%)
AgaP_AGAP002628	XP_312298.5	IG_like	30..111	CDD:214653	24/89 (27%)
		Ig	34..108	CDD:143165	22/82 (27%)
		I-set	113..200	CDD:254352	27/91 (30%)
		IGc2	129..189	CDD:197706	21/64 (33%)
		I-set	204..292	CDD:254352	25/98 (26%)
		Ig	212..292	CDD:299845	24/90 (27%)
		FN3	313..402	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X97
TreeFam	0	0.000	Not matched by this tool.
	3	2.810