DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and AgaP_AGAP010742

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_311455.4	Gene:	AgaP_AGAP010742 / 1272555	VectorBaseID:	AGAP010742	Length:	1195	Species:	Anopheles gambiae

Alignment Length:	422	Identity:	100/422 - (23%)
Similarity:	159/422 - (37%)	Gaps:	93/422 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 VITRNPRISVTHDKHDKHRTW---------------------FLHINNVQEEDRGRYMCQINTVT 143
            |.|.|| :|:::       ||                     .|:|..:...|.|.|.|:.....
Mosquito   637 VATGNP-MSISY-------TWTKDGLPILSSAGAQRIVSEGPILNITRLNRNDTGIYTCEAVNSQ 693

  Fly   144 AKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSP--EPTIKWKRDDGNKIVINKTL 206
            ...... :.|||.........|.::.|..|:...|.|..:|.|  |..|:|:| .|..:.| ||.
Mosquito   694 GSAMIN-ISVVVEYGASIQSISENVTVNPGEEAMLSCTVEGKPLTEEHIRWER-IGYDMTI-KTS 755

  Fly   207 EVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGF--N 269
            ......|..|.::...|..:|.:.|||.|.|....|:.:.:.|.|:|.:.....::....||  .
Mosquito   756 TTFANGTSYLHVKNARREDVGNFRCIADNRVANPTSRDVLLIVKFAPEIDKSPVMLRAAAGFGER 820

  Fly   270 ITLECFIEANPTSLNYWTRENDQM-ITESSKYKTETIPGHPSYKATMR---LTITNVQSSDYGNY 330
            ..|.|..:|.|....||:|....: :.:|:|:..|    |....|...   |.:..|.|:|||.|
Mosquito   821 ARLPCRAQAAPRPKFYWSRSGQVLNVNQSAKFYVE----HKQIDALTYESILVVERVASNDYGLY 881

  Fly   331 KCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTTLRRT---TTTAAEIALDGYINT-------PLN 385
            :|:|:|..|::...::|.::|||  .||.:...|..|   .|.|.....||.:..       .||
Mosquito   882 ECIARNELGNVKEKVRLDVTSPP--DPPVSLNVLNVTHDSVTLAWTPGFDGGMKANYRIRYRELN 944

  Fly   386 GNGIGIVGEGPTN----------------SVIAS-GKSSIKYLSNLNEIDKSKQKLTGSSPKGFD 433
            .:........|.:                |::|| |..|.:||.::....
Mosquito   945 SDRYWYEDSQPNSYKLTIGGLRMNTLYVFSIMASNGLGSSRYLPDVTRAH--------------- 994

  Fly   434 WSKGKSSGSHGNLMAS----SWPLICCILALL 461
             :|||...:...::.|    |:.:.|..||.|
Mosquito   995 -TKGKERQARLFMVQSAEIPSFVIFCIALAAL 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	14/75 (19%)
		Ig	69..139	CDD:143165	13/59 (22%)
		IG_like	165..249	CDD:214653	25/85 (29%)
		IGc2	172..237	CDD:197706	21/66 (32%)
		IG_like	267..348	CDD:214653	25/86 (29%)
		Ig	270..339	CDD:299845	22/72 (31%)
AgaP_AGAP010742	XP_311455.4	Ig	12..106	CDD:299845
		IG_like	14..106	CDD:214653
		IG_like	124..197	CDD:214653
		Ig	133..215	CDD:299845
		Ig	221..297	CDD:299845
		I-set	419..509	CDD:254352
		Ig	438..509	CDD:299845
		Ig	530..599	CDD:299845
		IG_like	531..610	CDD:214653
		IG_like	623..704	CDD:214653	14/75 (19%)
		IGc2	628..694	CDD:197706	13/64 (20%)
		IG_like	714..798	CDD:214653	25/85 (29%)
		Ig	725..786	CDD:299845	20/62 (32%)
		Ig	798..905	CDD:299845	32/112 (29%)
		I-set	802..900	CDD:254352	27/101 (27%)
		FN3	904..991	CDD:238020	19/88 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910