DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and AgaP_AGAP000659

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_311185.5	Gene:	AgaP_AGAP000659 / 1272415	VectorBaseID:	AGAP000659	Length:	2177	Species:	Anopheles gambiae

Alignment Length:	351	Identity:	79/351 - (22%)
Similarity:	135/351 - (38%)	Gaps:	59/351 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ISEDPEFTDVIENITV-PAGRNVKLACSVKNLGSYKVAWMH----FEQSAILTVHNHVITRNPRI 107
            :.|.|.|...:...|: ..|....|||.|......|:.|..    .||.|            .|.
Mosquito   290 VQEPPTFVTPLRTETLGEYGSRTVLACDVIGEPLPKITWFKNAWPIEQVA------------GRY 342

  Fly   108 SVTHDKHDKHRTWFLHINNVQEEDRGRYMC-QINTVTAKTQYGFVKV-------VVPPNIDDALT 164
            :|..|..       |.|..:..:|...:.| ..|....|:.|.::||       .:||      .
Mosquito   343 TVQDDNS-------LEIYKLGMDDTAMFQCLATNEAGEKSAYTWLKVKTSIPFMEIPP------V 394

  Fly   165 SSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAY 229
            :..|:  :|.:.|:.|:|..:|.|:|:|..:|...|..:..:::  |::..|.:..:.....|.|
Mosquito   395 NQTIL--DGKDATMNCRAIAAPTPSIQWIFNDTYPIETSSRMQI--LDSGDLLISNVRETDGGLY 455

  Fly   230 LCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNY---WTREND 291
            .||..|.....:.... ::|.....:..|.....:.:|.:..|||.:.::|| :.|   |.||.:
Mosquito   456 TCIRENEAGRVIGSGY-LTVLVRTQINRPPADTTVLLGHSAALECGVSSDPT-VPYNIDWYREPN 518

  Fly   292 QMITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYM----SSP 352
            ::..::|:        ....|....|.||.|:.||.|.|.|:..:|.|:...:.:|.:    .:|
Mosquito   519 RLPIKNSQ--------RIGVKKDGTLEITEVRPSDVGQYSCIVTSPGGNETRSARLSVIELPFAP 575

  Fly   353 PTTQPPPTTTTLRRTTTTAAEIALDG 378
            ...|....||...|....:.....||
Mosquito   576 SNVQAVRLTTPQNRAINVSWTPGFDG 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	23/108 (21%)
		Ig	69..139	CDD:143165	16/74 (22%)
		IG_like	165..249	CDD:214653	18/83 (22%)
		IGc2	172..237	CDD:197706	17/64 (27%)
		IG_like	267..348	CDD:214653	23/83 (28%)
		Ig	270..339	CDD:299845	21/71 (30%)
AgaP_AGAP000659	XP_311185.5	I-set	6..84	CDD:254352
		IGc2	21..79	CDD:197706
		I-set	195..290	CDD:254352	79/351 (23%)
		IGc2	211..273	CDD:197706
		Ig	293..382	CDD:299845	23/107 (21%)
		I-set	294..382	CDD:254352	23/106 (22%)
		IG_like	393..474	CDD:214653	19/91 (21%)
		IGc2	401..464	CDD:197706	17/64 (27%)
		Ig	484..568	CDD:299845	24/92 (26%)
		IG_like	484..568	CDD:214653	24/92 (26%)
		FN3	575..675	CDD:238020	7/27 (26%)
		FN3	684..779	CDD:238020
		FN3	787..909	CDD:238020
		FN3	914..998	CDD:238020
		FN3	1012..1101	CDD:238020
		FN3	1114..1228	CDD:238020
		FN3	1237..1330	CDD:238020
		FN3	1335..1427	CDD:238020
		FN3	1433..1528	CDD:238020
		fn3	1538..1628	CDD:278470
		FN3	1642..1743	CDD:238020
		FN3	1748..1839	CDD:238020
		FN3	1846..1935	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810