DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and AgaP_AGAP000218

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_310916.5	Gene:	AgaP_AGAP000218 / 1272049	VectorBaseID:	AGAP000218	Length:	884	Species:	Anopheles gambiae

Alignment Length:	400	Identity:	102/400 - (25%)
Similarity:	164/400 - (41%)	Gaps:	68/400 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LYVGLGCLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLACSVK 76
            |..|...|:.|...:.| |.|.|::.:.||..        .:|....:|.|...|..|.|.|.|:
Mosquito    11 LVYGTFALLLSRTVVHT-TASAGSSSSGGGGV--------QKFAMEPQNQTAIVGSRVTLPCRVE 66

  Fly    77 NLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQI-- 139
            :    ||..:.:.:.......:..::...|.|:...  |:...:.|.|..:..:|..||.||:
Mosquito    67 S----KVGQLQWTKDDFGLGWHRNLSGFDRYSMVGS--DEEGDYSLEIYPLMLDDEARYQCQVGR 125

  Fly   140 ---NTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRC-KAKGSPEPTIKWKRDDGNKI 200
               .|...::.:..:.|:|||.....:....::..|...:.|.| ...|.|...|.|  .||:..
Mosquito   126 GKDGTPGIRSSFATLTVLVPPEPPKIVQGDFLVTTEDREIELECVSVGGKPAAEITW--IDGHGT 188

  Fly   201 VINKTLE-VHDLETDS--------LELERISRLHMGAYLCIASNGVPPSV-SKRIKVSVDFSPMV 255
            |:.|.:| |.:...|:        |:|......|..::.|.|.|....:. |.|:|:.|.::|.|
Mosquito   189 VLTKGIEYVKEPMGDTGRFTAKSILKLTPKKEHHNTSFTCQAQNTADRTYRSVRLKLEVKYAPKV 253

  Fly   256 WIPHQLVG-------IPIGFNITLECFIEANPTSLNY-WTRENDQMITESSKYKTETIPGHPSYK 312
            .:  .:||       ||.|..:.|.|..:|||:.:.| |.|.::.::.:   |.||
Mosquito   254 SV--SVVGGALAGGRIPEGAEVRLSCRADANPSDVTYRWYRADEPIVGD---YTTE--------- 304

  Fly   313 ATMRLTITNVQSSDYGN--YKCVAKNPRGDMDGNIKLYMSSPPT--TQPPPTTTTLRRTTTTAAE 373
                |.|.|| |.:|.:  .||...|..|..:.:..|.:|..||  |:|....|.|.|..|.|.:
Mosquito   305 ----LVIHNV-SKEYHDAVIKCEVHNAVGKSEESEILDISYGPTFRTRPQSVETDLDRKVTLACD 364

  Fly   374 IALDGYINTP 383
            :  ||  |.|
Mosquito   365 V--DG--NPP 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	21/100 (21%)
		Ig	69..139	CDD:143165	15/69 (22%)
		IG_like	165..249	CDD:214653	23/94 (24%)
		IGc2	172..237	CDD:197706	20/74 (27%)
		IG_like	267..348	CDD:214653	22/83 (27%)
		Ig	270..339	CDD:299845	20/71 (28%)
AgaP_AGAP000218	XP_310916.5	IG_like	48..142	CDD:214653	20/99 (20%)
		Ig	52..144	CDD:299845	20/97 (21%)
		C2-set_2	149..239	CDD:285423	20/91 (22%)
		Ig_3	250..325	CDD:290638	26/93 (28%)
		I-set	342..423	CDD:254352	12/32 (38%)
		Ig	343..>396	CDD:299845	11/31 (35%)
		Ig	424..516	CDD:299845
		IG_like	431..516	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810