DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and AgaP_AGAP009518

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_310174.4	Gene:	AgaP_AGAP009518 / 1271391	VectorBaseID:	AGAP009518	Length:	464	Species:	Anopheles gambiae

Alignment Length:	442	Identity:	101/442 - (22%)
Similarity:	169/442 - (38%)	Gaps:	102/442 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 HF-EQSAILTV----HNHVIT--RNPR---ISVTHDK---HDKHRTWFLHINNVQEEDRGRYMCQ 138
            || .||.::|.    |..|..  |||:   ||.|..:   .||..:..|....:...|:|.:.|:
Mosquito    37 HFVNQSRMVTCSHPDHPEVRLKWRNPKNAIISETKGRVHIEDKGDSLALIFEAIARTDQGNWTCE 101

  Fly   139 INTV-TAKTQYGFV---------KVVV--PPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIK 191
            ::.. ||....|.|         |::|  |.:..|..|....:  |..:.|:||:.||.|||::.
Mosquito   102 VDVEGTATATEGRVTVPALRKSFKMIVYEPISFRDTNTVQTAV--EDKDATIRCEVKGHPEPSVS 164

  Fly   192 WKRDDGN----KIVINKTLEVHDLETDSLELERISRLHMGAYLC----IASNGVPPSVSKRIKVS 248
            | ..:|.    |:..|...  :....|.:.::::.:...|.|.|    |::.| .....|.|:::
Mosquito   165 W-YFNGQPLFCKLFSNNGR--YSKLADGMSIKKVVQNDSGEYTCKAFQISATG-SSFEEKTIRLN 225

  Fly   249 VDFSPMVWIPHQLVGIP-----IGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGH 308
            :...|  ::|.....|.     :|..:.|.|...|.|.:...|:..|.::..:|          |
Mosquito   226 IKHKP--YMPPWKKSISDAYGYVGGMVNLTCEATAEPPANFSWSANNKKLTPKS----------H 278

  Fly   309 PSY--KATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTTA 371
            ..|  :....|.|....||.:|.|||.|||..|.:...|.|...:.|   .||:...||...:..
Mosquito   279 IIYNGRHVSMLQIMIKTSSIFGKYKCEAKNELGSVTQEIHLKEGTKP---DPPSLFQLRGVNSDT 340

  Fly   372 AEIALDGYINTPLNGNGIGIVGEG----PTNSV---------------IASGKSSI--------K 409
            .:|.:....:..:..:...::|..    ||:..               :|.|.:.:        |
Mosquito   341 LDIDVGATKSHDIPPDPTTVIGYRFELMPTDEYLKSRSWDHASRRDFDVADGATYLLVQLIPDTK 405

  Fly   410 YLSNLNEIDKSKQKLTGSSPKGFDWSKGKSSGS-----HGNLMASSWPLICC 456
            ||     |..:.:...|.|    ||::.|...:     ||...:|:.|...|
Mosquito   406 YL-----IRVAARNAAGLS----DWTEVKEFSTHPVQPHGTSGSSAQPTDVC 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/90 (27%)
		Ig	69..139	CDD:143165	19/64 (30%)
		IG_like	165..249	CDD:214653	21/91 (23%)
		IGc2	172..237	CDD:197706	18/72 (25%)
		IG_like	267..348	CDD:214653	23/82 (28%)
		Ig	270..339	CDD:299845	20/70 (29%)
AgaP_AGAP009518	XP_310174.4	IG_like	45..117	CDD:214653	19/71 (27%)
		Ig	<67..102	CDD:299845	9/34 (26%)
		IGc2	145..207	CDD:197706	17/64 (27%)
		IG_like	240..320	CDD:214653	23/89 (26%)
		Ig	250..318	CDD:143165	21/77 (27%)
		FN3	325..429	CDD:238020	20/115 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810