DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and AgaP_AGAP010969

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_309726.4	Gene:	AgaP_AGAP010969 / 1270988	VectorBaseID:	AGAP010969	Length:	1098	Species:	Anopheles gambiae

Alignment Length:	415	Identity:	94/415 - (22%)
Similarity:	163/415 - (39%)	Gaps:	64/415 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SEGNAGNV--GGSTLNNVISEDPEFTDVIENITVPAGRNVKLACS-VKNLGSYKVAWMHFEQSAI 93
            :...||.|  ..:||......| :|....:|..|.||....|.|| .:......|:|.  :....
Mosquito    80 ASNQAGKVYSRNATLQVATLRD-DFRVEPKNTRVAAGETALLECSPPRGNPEPNVSWK--KNDGF 141

  Fly    94 LTVHNHVITRN-PRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPP 157
            |.:.::..::. .||.:....:       |.|::|:..|.|||.|....:....:.|..|:.|..
Mosquito   142 LELDDYRPSKELARIRIVDSGN-------LLISDVRPTDEGRYQCIAQNMVGSRESGLAKLTVQV 199

  Fly   158 NIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERIS 222
            .........|..|.||..|..:|...|.|.|.|.|.:..|: |.:.:. |:.: |..||.:..::
Mosquito   200 KPYFVAEPDDATVLEGHRVQFQCAVGGDPAPQILWTKQHGD-IPVGRA-EISE-EDRSLIIRNVT 261

  Fly   223 RLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWT 287
            ....|.|:|.|.|.| ..:|.|..::|:..|:..:..|...:.:...:|.:|....:|....:||
Mosquito   262 ADDHGQYICEARNSV-GVISARASLTVNTPPVFIVRPQDQKVTVNGVVTFKCSAGGSPLPSVFWT 325

  Fly   288 RENDQ-MITESSKYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSS 351
            ||..| ::..::.|....:.|..|      |.|..||..|.|.:.|.|.:..|.:...:.|.::|
Mosquito   326 REGSQTLMFPNNSYGNMHVSGQGS------LQIRGVQREDDGYFVCSALSVAGSVTSRVYLQVTS 384

  Fly   352 PPTTQPPPTTTTLRRTTTTAAEIALDGYINTPLNGNGIGIVGEGPTNSVIASG-KSSIKYLSNL- 414
            |..:.|||                               ::.:.|:|..:.|| |:::...|:.
Mosquito   385 PIDSIPPP-------------------------------LLQQVPSNQSLPSGTKATLPCRSSAY 418

  Fly   415 ---NEIDKSKQKLTGSSPKGFDWSK 436
               :....|....:.|:|:   |.:
Mosquito   419 GAPSSSSSSSSTASSSAPR---WQR 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	22/97 (23%)
		Ig	69..139	CDD:143165	16/71 (23%)
		IG_like	165..249	CDD:214653	25/83 (30%)
		IGc2	172..237	CDD:197706	20/64 (31%)
		IG_like	267..348	CDD:214653	20/81 (25%)
		Ig	270..339	CDD:299845	19/69 (28%)
AgaP_AGAP010969	XP_309726.4	Ig	5..97	CDD:299845	5/16 (31%)
		I-set	5..96	CDD:254352	5/15 (33%)
		I-set	103..197	CDD:254352	23/102 (23%)
		Ig	105..197	CDD:299845	22/100 (22%)
		I-set	201..287	CDD:254352	25/89 (28%)
		Ig	218..287	CDD:299845	21/72 (29%)
		IG_like	297..382	CDD:214653	22/90 (24%)
		Ig	308..391	CDD:299845	23/88 (26%)
		IG_like	398..493	CDD:214653	10/46 (22%)
		Ig	<438..493	CDD:299845	1/3 (33%)
		FN3	511..609	CDD:238020
		FN3	637..726	CDD:238020
		fn3	733..820	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910