DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-epsilon and AgaP_AGAP007092

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_308666.4	Gene:	AgaP_AGAP007092 / 1270011	VectorBaseID:	AGAP007092	Length:	1805	Species:	Anopheles gambiae

Alignment Length:	363	Identity:	91/363 - (25%)
Similarity:	155/363 - (42%)	Gaps:	61/363 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TVPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINN 126
            ||..|::.:..|.:....:::|.|||..:..:......:.|..|||.               |.|
Mosquito   202 TVDVGKDAQFQCIISGFPAHEVLWMHNGKPIVRDSRIEIYTDVPRIV---------------IKN 251

  Fly   127 VQEEDRGRYMC-------QINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKG 184
            ||:||:|.|.|       ||.: ||:.|.|......|..:   ...|:..::.|..|:|:|...|
Mosquito   252 VQKEDQGMYQCFVANEWEQIQS-TAELQLGGEWDATPELL---YWFSEQTLQPGPTVSLKCVGTG 312

  Fly   185 SPEPTIKWKRD-----DGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKR 244
            :|.|...||.|     |..:.|:.:.:.:||.....:.:..:.....|.|.|:|.|.: ..||..
Mosquito   313 NPPPQFTWKLDGFPIPDSPRFVVGQYVTIHDDVISHVNISNVKEEDGGEYTCVAQNSI-GRVSHS 376

  Fly   245 IKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHP 309
            .||::...|.:....::.|:. |.::.::|.:...|....:|.|:.            :|:|.:.
Mosquito   377 AKVNIYGLPYIREMPKITGVS-GHDLIIKCPVAGYPIDKIHWERDG------------QTLPINR 428

  Fly   310 SYKA--TMRLTITNVQ-SSDYGNYKCVAKN-PRGDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTT 370
            ..:|  ...|.|..:| :.|.|.|.|:|:| .:.....|:::.:..||...|....|.:.|....
Mosquito   429 RQRAYNNGTLIIEQLQLAEDAGTYTCMAQNKQKQTARRNVEIQVIVPPKIMPIQAMTNMLREGMR 493

  Fly   371 AA---EIALDGYINTPLN----GNGIGIVGEGPTNSVI 401
            ||   :| |:|  :.|:|    .||..::|.|  |.||
Mosquito   494 AAISCQI-LEG--DLPVNFRWERNGKPVLGTG--NEVI 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	27/99 (27%)
		Ig	69..139	CDD:143165	18/76 (24%)
		IG_like	165..249	CDD:214653	24/88 (27%)
		IGc2	172..237	CDD:197706	19/69 (28%)
		IG_like	267..348	CDD:214653	18/84 (21%)
		Ig	270..339	CDD:299845	16/72 (22%)
AgaP_AGAP007092	XP_308666.4	IG	3..71	CDD:214652
		IG	108..188	CDD:214652
		Ig	115..185	CDD:143165
		IG_like	198..278	CDD:214653	25/91 (27%)
		IGc2	206..268	CDD:197706	19/76 (25%)
		IG	294..381	CDD:214652	24/87 (28%)
		Ig	304..378	CDD:143165	20/74 (27%)
		IG	391..472	CDD:214652	19/93 (20%)
		IGc2	397..459	CDD:197706	16/74 (22%)
		IG_like	489..568	CDD:214653	15/43 (35%)
		Ig	496..564	CDD:143165	12/36 (33%)
		I-set	572..666	CDD:254352
		Ig	589..666	CDD:299845
		I-set	671..767	CDD:254352
		Ig	689..774	CDD:299845
		FN3	771..864	CDD:238020
		FN3	871..975	CDD:238020
		FN3	982..1075	CDD:238020
		FN3	1080..1172	CDD:238020
		IGc2	1195..1256	CDD:197706
		FN3	1269..1359	CDD:238020
		FN3	1364..1445	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810