DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and CEACAM20

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_011524731.1	Gene:	CEACAM20 / 125931	HGNCID:	24879	Length:	623	Species:	Homo sapiens

Alignment Length:	377	Identity:	82/377 - (21%)
Similarity:	129/377 - (34%)	Gaps:	118/377 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPA-----------GRNVKL 71
            ||:::|   :|...|.|        ||.         ..|:|.:|:|.           .|:|.|
Human   257 CLVSNS---ATHLSSLG--------TLK---------VRVLETLTMPQVVPSSLNLVENARSVDL 301

  Fly    72 ACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYM 136
            .|...| .|..|.|....|..:.:.|..:...|             ||..:|  .:|..|.|.|.
Human   302 TCQTVN-QSVNVQWFLSGQPLLPSEHLQLSADN-------------RTLIIH--GLQRNDTGPYA 350

  Fly   137 CQI---------NTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKW 192
            |::         ..:.....||..:|.:.......:.|: |......::||:|.|:..|....:|
Human   351 CEVWNWGSRARSEPLELTINYGPDQVHITRESASEMIST-IEAELNSSLTLQCWAESKPGAEYRW 414

  Fly   193 KRDD------GNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASN---GVPPSVSKRIKV- 247
            ..:.      |.:::|......||                |.|.|.|||   |:..|.|..:||
Human   415 TLEHSTGEHLGEQLIIRALTWEHD----------------GIYNCTASNSLTGLARSTSVLVKVV 463

  Fly   248 ---SVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYW-----TRENDQMITESSKYKT-E 303
               |...|     ...:.||.||....:     |..:.|.|:     .|...:..||...::| :
Human   464 GPQSSSLS-----SGAIAGIVIGILAVI-----AVASELGYFLCIRNARRPSRKTTEDPSHETSQ 518

  Fly   304 TIP--GHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPP 353
            .||  .||:..::..|      |.:|.|.        ..:.|.|::.:..||
Human   519 PIPKEEHPTEPSSESL------SPEYRNI--------SQLQGRIRVELMQPP 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	25/115 (22%)
		Ig	69..139	CDD:143165	18/69 (26%)
		IG_like	165..249	CDD:214653	23/96 (24%)
		IGc2	172..237	CDD:197706	16/73 (22%)
		IG_like	267..348	CDD:214653	18/88 (20%)
		Ig	270..339	CDD:299845	15/76 (20%)
CEACAM20	XP_011524731.1	Ig	96..183	CDD:299845
		IG_like	97..170	CDD:214653
		Ig_2	202..274	CDD:290606	8/36 (22%)
		IG_like	202..274	CDD:214653	8/36 (22%)
		Ig	293..370	CDD:299845	19/92 (21%)
		IG_like	388..460	CDD:214653	21/88 (24%)
		Ig_2	396..462	CDD:290606	19/81 (23%)
		C_Hendra	499..>554	CDD:293426	14/68 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910