DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and ncam1b

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_005157462.1	Gene:	ncam1b / 114442	ZFINID:	ZDB-GENE-010822-2	Length:	1055	Species:	Danio rerio

Alignment Length:	394	Identity:	89/394 - (22%)
Similarity:	146/394 - (37%)	Gaps:	85/394 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLACSVKN------LGSYK 82
            ||.|.|..:|        :|:|..|.:...||:|........|.|..:.|.|.:      |..||
Zfish    95 VASSGDQDAE--------ATVNLKIYQKITFTNVPSPQEFTEGDNAIIVCDVISSPPPTVLWKYK 151

  Fly    83 VAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQ 147
            .|.:.|:             ::.|.....:.|       |.|..:::.|.|.|.|: ..:.|:.:
Zfish   152 GAKIQFD-------------KDVRFKTLSNNH-------LQIRGIRKTDEGVYTCE-GRIKARGE 195

  Fly   148 YGF--VKVVVP--PNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKR-----DDGNKIVIN 203
            ..|  :||||.  |.|......::.....|.:..|.|...|.|||.:.|:|     :.|||...|
Zfish   196 VDFRSIKVVVNVLPTIRIRQAETNATADMGFSTLLACDPDGFPEPIVTWRRNNAPLESGNKYSFN 260

  Fly   204 KTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGF 268
            :       :...:.:..:::|..|.|.|||.|....| .:.:.:.|...|.:..........:..
Zfish   261 E-------DGSEMTVLDVTKLDEGDYTCIAKNKAGES-EQELSLKVFVQPKITYLESQTTTEMDE 317

  Fly   269 NITLECFIEANPTSLNYWT----------RENDQMITESSKYKTETIPGHPSYKATMR------- 316
            .:||.|....:||....|:          :|..:.|.::|..:.|...| |..:..:|
Zfish   318 QVTLTCEATGDPTPTITWSFGTRVFTEGEQEQQKRIYQASWTRPEQHKG-PDGEVLVRSDARVSS 381

  Fly   317 LTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTTAAEIALDGYIN 381
            ||:...|.:|.|.|.|.|:|..|:             |.|  |.:..:|........:|:..:..
Zfish   382 LTLKYPQYTDAGQYLCTARNAIGE-------------TVQ--PVSLEVRYAPKILGSVAVYTWEG 431

  Fly   382 TPLN 385
            .|.|
Zfish   432 NPAN 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	21/103 (20%)
		Ig	69..139	CDD:143165	15/75 (20%)
		IG_like	165..249	CDD:214653	21/88 (24%)
		IGc2	172..237	CDD:197706	20/69 (29%)
		IG_like	267..348	CDD:214653	23/97 (24%)
		Ig	270..339	CDD:299845	22/85 (26%)
ncam1b	XP_005157462.1	Ig	20..112	CDD:299845	7/24 (29%)
		I-set	21..111	CDD:254352	7/23 (30%)
		IG_like	121..205	CDD:214653	21/104 (20%)
		IGc2	128..189	CDD:197706	17/81 (21%)
		Ig	208..301	CDD:299845	24/100 (24%)
		I-set	212..298	CDD:254352	21/93 (23%)
		I-set	298..414	CDD:254352	28/131 (21%)
		Ig	300..414	CDD:299845	27/129 (21%)
		IG_like	426..505	CDD:214653	2/10 (20%)
		Ig	434..505	CDD:143165	1/2 (50%)
		FN3	513..606	CDD:238020
		FN3	629..720	CDD:238020
		Chorion_3	<815..1019	CDD:253174
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100