DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and si:dkey-24p1.7

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_005173465.1	Gene:	si:dkey-24p1.7 / 101883966	ZFINID:	ZDB-GENE-121214-215	Length:	598	Species:	Danio rerio

Alignment Length:	432	Identity:	84/432 - (19%)
Similarity:	142/432 - (32%)	Gaps:	132/432 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSFLYVGLGCLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGRNVKLAC 73
            |..:|.....||.:|.......|.:...||...:|.|.:..:..:...::...|:..|..:.|.|
Zfish   198 SEHVYYSYLTLIPTSDQHDGTVGCDVRYGNKKINTNNTLEVKYVQALQIVGENTLMEGDTLNLTC 262

  Fly    74 SVKNLGSYKVAWMHFEQSAILTVHNHVITRNP--RISVTHDK-HDKHRTWFLHINNVQEEDRGRY 135
                                 |..:|....||  |.:...|. :.:.....|.|.||.:|..|.|
Zfish   263 ---------------------TFRSHPPASNPVWRFNGNTDNLNTQTSAGTLMIANVGKEHAGIY 306

  Fly   136 MCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIK--WK-RDDG 197
            :|:: |...||....:.:    ||.:.....:..:::||.:.|.|..|..|:.:..  |. ..|.
Zfish   307 VCEM-TYMNKTLNASITI----NITEVNILGENRLKKGDTLNLTCSFKNHPQSSSNPVWSFNGDA 366

  Fly   198 NKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSV------------- 249
            :|:       .:.....:|.::.:::.|.|.|.| ....:..:::..|.|.:
Zfish   367 DKL-------KNQASAANLIIDNVTKEHAGIYAC-EMTYMKKTLNASITVDITEHDMGRNNTRAG 423

  Fly   250 --DFSPMVWIPHQLVGIP-------------IGFNITLECFI-----------EANP-TSLNYWT 287
              ||         |:.||             :.|::.|.|::           .||| ..:|..|
Zfish   424 VLDF---------LLSIPNIFTFVAGMAFSALIFSVILCCWVCCHRGKKQKVPTANPDAEINLET 479

  Fly   288 RENDQMITESSKYKTETIPGH-------PSYKATM-------RLTITNVQSSDYGNYKCVAKNPR 338
            .:.|  :.::.  .||..|.|       |...||.       ....|..:..||.:.
Zfish   480 VQTD--VAQNG--TTEQTPLHEQPDGETPKTPATPTDGAEEDEALGTEAREVDYASI-------- 532

  Fly   339 GDMDGNIKLYMSSPP---TTQPPPTTTTLRRTTTTAAEIALD 377
                 :..|....||   .|:|         |.|..|||..|
Zfish   533 -----DYSLLKDKPPEEAETEP---------TDTDYAEIKKD 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	21/98 (21%)
		Ig	69..139	CDD:143165	16/72 (22%)
		IG_like	165..249	CDD:214653	16/86 (19%)
		IGc2	172..237	CDD:197706	14/67 (21%)
		IG_like	267..348	CDD:214653	19/106 (18%)
		Ig	270..339	CDD:299845	18/94 (19%)
si:dkey-24p1.7	XP_005173465.1	Ig	27..132	CDD:299845
		IG_like	251..325	CDD:214653	21/99 (21%)
		Ig	254..323	CDD:299845	20/90 (22%)
		ig	336..394	CDD:278476	14/65 (22%)
		IG_like	339..408	CDD:214653	15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910