DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and SPEGNB

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001273740.1	Gene:	SPEGNB / 100996693	HGNCID:	51251	Length:	238	Species:	Homo sapiens

Alignment Length:	210	Identity:	54/210 - (25%)
Similarity:	76/210 - (36%)	Gaps:	56/210 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 PPNIDDALTSSDIIVREGDNVTLRCKAKGSPEPTIKWKRD-----DGNKI--------VINKTLE 207
            ||.:.:.|  .|:::.||....|.|:....|:|.|:|.:|     ||.|.        |:  .|.
Human    53 PPRVLEPL--KDVVLIEGSAAKLTCRISAFPDPFIRWSKDGKELRDGPKYRYVFEDPDVV--ALV 113

  Fly   208 VHDLETDSLELERISRLHMGAYLCIASNGVPP----SVSKRIKVSVDFSPMVWIPHQLVGIP--- 265
            |.|.|...|          |.|....:|   |    |.|.||        :|.:|.::...|
Human   114 VRDGELADL----------GQYSINVTN---PFGQCSDSARI--------LVEVPTKIQKGPDNT 157

  Fly   266 ---IGFNITLECFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQSSDY 327
               .|..:||...|...|.....||::.:. |.|..:...|.      ...|..|||......|.
Human   158 KARKGTTVTLTAEILGEPAPDVGWTKDGED-IEEDDRVFFEI------GSTTTTLTIRRATPQDS 215

  Fly   328 GNYKCVAKNPRGDMD 342
            |.|:...:|..| ||
Human   216 GKYEVYVENSLG-MD 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653
		Ig	69..139	CDD:143165
		IG_like	165..249	CDD:214653	27/100 (27%)
		IGc2	172..237	CDD:197706	21/77 (27%)
		IG_like	267..348	CDD:214653	21/76 (28%)
		Ig	270..339	CDD:299845	17/68 (25%)
SPEGNB	NP_001273740.1	IQ	27..49	CDD:197470
		I-set	54..144	CDD:369462	29/114 (25%)
		I-set	149..237	CDD:369462	22/89 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910