DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and igsf10

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_012819117.2	Gene:	igsf10 / 100494018	XenbaseID:	XB-GENE-6072998	Length:	2884	Species:	Xenopus tropicalis

Alignment Length:	383	Identity:	91/383 - (23%)
Similarity:	153/383 - (39%)	Gaps:	69/383 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LEAISSFLYV-GLGCLIASSVALSTDTGS-EGNAGNVGGS---TLNNVISED---PEFTDVIENI 61
            |:.:::.|:: ..|.|...:|| |||.|: |..|.:..||   .:|.::.:.   |:.||.....
Frog  2144 LQYVNAKLFLFSNGTLYIRNVA-STDRGNYECIATSSTGSERRVVNLIVEQSDTFPKITDASPKA 2207

  Fly    62 T-VPAGRNVKLACSVKNLGSYKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTWFLHIN 125
            | :..|..:.|.|:.......::.|....::.:..:|.    ...||.|       .....|.::
Frog  2208 TEMNFGDKLMLNCTATGEPKPRIIWRLPSKAVVDQLHR----MGSRIQV-------FPNGTLFVD 2261

  Fly   126 NVQEEDRGRYMCQINTVTAKTQYG----FVKVVVPPNIDDALTSSDIIVRE--------GDNVTL 178
            :|.::|.|.|:|     .|:.:.|    .:||.|      .:..:.||.::        |.:..:
Frog  2262 SVNDKDAGDYLC-----VARNKMGDDVILMKVSV------TMKPAKIIQKQPLAKQVPYGKDFKV 2315

  Fly   179 RCKAKGSPEPTIKWKRDDGNKIVINKTLEVHD----------LETDSLELERISRLHMGAYLCIA 233
            .|||.|||.|.|.|...||.  :||..|:..|          .:..:|.|.::.....|.|.|.|
Frog  2316 DCKASGSPLPDISWSLPDGT--MINNILQADDSGRRKRRYILFDNGTLYLNKVGIAEEGDYTCYA 2378

  Fly   234 SNGVPPSVSKRIKVSVDFSPMVWIPHQL-VGIPIGFNITLECFIEANPTSLNYWTRENDQMITES 297
            .|.:.....|.....|..:|::.:..:. .....|.::.|:|.....|....:|...:..||..|
Frog  2379 ENQLGRDEMKVHITVVTAAPLIKLNMKTRYAAMAGESVILDCEANGEPKPKIFWLLPSSDMIAIS 2443

  Fly   298 SKYKTETIPGHPSY--KATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPP 353
                      |..|  .....||::.|:..|.|.|.|||:||.||....::|.:...|
Frog  2444 ----------HDRYLLHENGSLTVSQVKLLDAGEYMCVARNPAGDDTKLLRLEVHPKP 2491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	19/100 (19%)
		Ig	69..139	CDD:143165	13/69 (19%)
		IG_like	165..249	CDD:214653	26/101 (26%)
		IGc2	172..237	CDD:197706	23/82 (28%)
		IG_like	267..348	CDD:214653	23/82 (28%)
		Ig	270..339	CDD:299845	20/70 (29%)
igsf10	XP_012819117.2	leucine-rich repeat	40..59	CDD:275380
		leucine-rich repeat	60..83	CDD:275380
		PPP1R42	68..221	CDD:411060
		LRR_8	82..142	CDD:404697
		leucine-rich repeat	84..107	CDD:275380
		leucine-rich repeat	108..131	CDD:275380
		leucine-rich repeat	132..155	CDD:275380
		leucine-rich repeat	156..187	CDD:275380
		leucine-rich repeat	188..211	CDD:275380
		PCC	193..>277	CDD:188093
		Ig	477..552	CDD:416386
		Ig strand A'	481..484	CDD:409353
		Ig strand B	490..497	CDD:409353
		Ig strand C	503..509	CDD:409353
		Ig strand C'	511..517	CDD:409353
		Ig strand D	524..528	CDD:409353
		Ig strand E	531..536	CDD:409353
		Ig strand F	544..552	CDD:409353
		IGc2	585..649	CDD:197706
		Ig strand C	601..606	CDD:409353
		Ig strand C'	608..612	CDD:409353
		Ig strand D	617..622	CDD:409353
		Ig strand E	625..631	CDD:409353
		Ig strand F	638..646	CDD:409353
		Herpes_BLLF1	<885..1272	CDD:282904
		Ig_3	1904..1984	CDD:404760
		Ig strand C	1936..1940	CDD:409353
		Ig strand E	1963..1967	CDD:409353
		Ig strand F	1977..1982	CDD:409353
		Ig strand G	1991..1994	CDD:409353
		Ig_3	2001..2081	CDD:404760
		Ig strand A'	2011..2014	CDD:409353
		Ig strand B	2020..2027	CDD:409353
		Ig strand C	2033..2038	CDD:409353
		Ig strand C'	2040..2042	CDD:409353
		Ig strand D	2053..2057	CDD:409353
		Ig strand E	2060..2065	CDD:409353
		Ig strand F	2073..2081	CDD:409353
		Ig strand G	2084..2094	CDD:409353
		Ig_3	2098..2177	CDD:404760	11/33 (33%)
		Ig strand A	2098..2101	CDD:409353
		Ig strand A'	2107..2110	CDD:409353
		Ig strand B	2117..2124	CDD:409353
		Ig strand C	2130..2136	CDD:409353
		Ig strand C'	2142..2144	CDD:409353	91/383 (24%)
		Ig strand D	2150..2155	CDD:409353	1/4 (25%)
		Ig strand E	2157..2161	CDD:409353	2/3 (67%)
		Ig strand F	2170..2178	CDD:409353	3/7 (43%)
		Ig strand G	2181..2191	CDD:409353	3/9 (33%)
		Ig_3	2198..2277	CDD:404760	19/94 (20%)
		Ig strand B	2214..2223	CDD:409353	2/8 (25%)
		Ig strand C	2229..2238	CDD:409353	1/8 (13%)
		Ig strand D	2250..2253	CDD:409353	2/9 (22%)
		Ig strand E	2256..2262	CDD:409353	1/5 (20%)
		Ig strand F	2269..2277	CDD:409353	4/12 (33%)
		Ig_3	2293..2380	CDD:404760	24/88 (27%)
		Ig strand A'	2304..2309	CDD:409353	0/4 (0%)
		Ig strand C	2326..2330	CDD:409353	1/3 (33%)
		Ig strand D	2355..2358	CDD:409353	0/2 (0%)
		Ig strand E	2359..2364	CDD:409353	1/4 (25%)
		Ig strand F	2372..2380	CDD:409353	4/7 (57%)
		IGc2	2413..2477	CDD:197706	21/73 (29%)
		Ig strand B	2416..2420	CDD:409353	1/3 (33%)
		Ig strand C	2429..2433	CDD:409353	0/3 (0%)
Ig strand E	2453..2457	CDD:409353	1/3 (33%)
Ig strand F	2467..2472	CDD:409353	2/4 (50%)
Ig strand B	2515..2521	CDD:409353
IG_like	2516..2587	CDD:214653
Ig strand C	2527..2532	CDD:409353
Ig strand C'	2534..2536	CDD:409353
Ig strand D	2546..2550	CDD:409353
Ig strand E	2553..2558	CDD:409353
Ig strand F	2566..2574	CDD:409353
Ig strand G	2577..2587	CDD:409353
Ig	2612..2675	CDD:409353
Ig strand B	2612..2616	CDD:409353
Ig strand C	2625..2629	CDD:409353
Ig strand E	2651..2655	CDD:409353
Ig strand F	2665..2670	CDD:409353
Ig_3	2688..2767	CDD:404760
Ig strand B	2707..2711	CDD:409353
Ig strand C	2720..2724	CDD:409353
Ig strand E	2746..2750	CDD:409353
Ig strand F	2760..2765	CDD:409353
Ig_3	2784..2866	CDD:404760
Ig strand A	2785..2790	CDD:409353
Ig strand A'	2793..2798	CDD:409353
Ig strand B	2801..2810	CDD:409353
Ig strand C	2816..2820	CDD:409353
Ig strand C'	2823..2825	CDD:409353
Ig strand D	2841..2844	CDD:409353
Ig strand E	2845..2850	CDD:409353
Ig strand F	2858..2866	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910