DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and igsf9b

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_031761656.1	Gene:	igsf9b / 100379858	XenbaseID:	XB-GENE-5887265	Length:	1392	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	115/523 - (21%)
Similarity:	187/523 - (35%)	Gaps:	132/523 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YHLEAISSFLYVGLGCLIASSVALSTDTGSEGNAGNVGGSTLNNVISEDPEFTDVIENITVPAGR 67
            |.|..|:|         :.|::.||..        ..|||      .|:|:|      :|..||.
Frog     4 YVLTLIAS---------VISTLGLSVQ--------GAGGS------REEPQF------VTARAGE 39

  Fly    68 NVKLACSVKN-----LGSYKVAWMHFEQSAILTVH-----NHVITRNPRISVTHDKHDKHRTWFL 122
            :|.|.|.|.:     ...|.|.|..|.....:.:.     .||.......:..:||..      |
Frog    40 SVILGCDVVHPLTVQPPPYVVEWFKFGVPIPIFIKFGFYPPHVDPEYVGRAALYDKAS------L 98

  Fly   123 HINNVQEEDRGRYMCQINTVTAKTQY------GFVKVVV--PPNIDDALTSSDIIVREGDNVTLR 179
            .|..|:.:|:|.|.|::  :..:.||      .:|.:.|  ||...:. ....:.|:||.::||.
Frog    99 RIEQVRSQDQGWYECKV--LMLEHQYDTFHNGSWVHLTVNAPPTFTET-PPQYLEVKEGSSITLT 160

  Fly   180 CKAKGSPEPTIKWKRDDGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGVPPSVSKR 244
            |.|.|:|:||:.|.|:..   .:.:|.: :.|...||.:..|.|...|:|:|.|:: :.......
Frog   161 CTAFGNPKPTVSWLREGE---FLGRTSK-YQLSDGSLTISSIGREDRGSYMCRATS-IQGEAVHS 220

  Fly   245 IKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLN---YWTRENDQMITESSKYKTETIP 306
            .::.|..||.:..|.:.:.:.|..:....|..||.|.:|.   ||..||.....:........|.
Frog   221 TRLLVQGSPFIVSPPENITVNISQDALFTCQAEAYPGNLTYTWYWQEENVFFKNDLKLRVRILID 285

  Fly   307 GHPSYKATMRLTITNVQSSDYGNYKCVAKNPRG----------------------------DMDG 343
            |        .|.|..|:..|.|.|.||..|..|                            .:.|
Frog   286 G--------TLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVVNMPPVIYVPVGIHG 342

  Fly   344 NIKLYMSSPPTTQPPPTT--------TTLRRTTTTAAEIALDGYIN------------TPLNGNG 388
            :|:.     |....||.|        ..||....:..::..||.|:            |.:..|.
Frog   343 HIRC-----PVEAVPPVTFVKWNKDGRPLRIDKFSGWKLLDDGTIHVEEATEELLGTYTCVPYNA 402

  Fly   389 IGIVGEGPTNSVIASGKSSIKYLSNLNEIDKSKQKL------TGSSPKGFDWSK-GKSSGSHGNL 446
            :|.:|:.|...::.........|.......::.::|      .|.......|.| |:.|.|..::
Frog   403 LGTMGQSPPARLLLKDPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPSISWRKVGRPSFSKHSV 467

  Fly   447 MAS 449
            :.|
Frog   468 LPS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	25/111 (23%)
		Ig	69..139	CDD:143165	19/79 (24%)
		IG_like	165..249	CDD:214653	23/83 (28%)
		IGc2	172..237	CDD:197706	22/64 (34%)
		IG_like	267..348	CDD:214653	23/111 (21%)
		Ig	270..339	CDD:299845	20/71 (28%)
igsf9b	XP_031761656.1	IG	30..115	CDD:214652	24/96 (25%)
		I-set	139..225	CDD:400151	24/91 (26%)
		Ig strand A	139..142	CDD:409353	1/2 (50%)
		Ig strand A'	148..151	CDD:409353	0/2 (0%)
		Ig strand B	157..164	CDD:409353	3/6 (50%)
		Ig strand C	170..175	CDD:409353	2/4 (50%)
		Ig strand D	185..189	CDD:409353	0/4 (0%)
		Ig strand E	191..195	CDD:409353	2/3 (67%)
		Ig strand F	204..212	CDD:409353	4/7 (57%)
		Ig strand G	215..225	CDD:409353	0/9 (0%)
		I-set	229..321	CDD:400151	24/99 (24%)
		Ig strand B	246..250	CDD:409353	0/3 (0%)
		Ig strand C	260..264	CDD:409353	0/3 (0%)
		Ig strand E	286..290	CDD:409353	2/11 (18%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
		Ig strand G	314..317	CDD:409353	0/2 (0%)
		Ig	344..405	CDD:409353	12/65 (18%)
		Ig strand C	355..360	CDD:409353	1/4 (25%)
		Ig strand E	380..384	CDD:409353	2/3 (67%)
		Ig strand F	394..399	CDD:409353	1/4 (25%)
		Ig	429..505	CDD:416386	8/42 (19%)
		Ig strand A'	429..432	CDD:409353	0/2 (0%)
		Ig strand B	438..445	CDD:409353	1/6 (17%)
		Ig strand C	451..456	CDD:409353	1/4 (25%)
		Ig strand C'	458..460	CDD:409353	1/1 (100%)
		Ig strand E	471..476	CDD:409353	115/523 (22%)
		Ig strand F	484..492	CDD:409353
		Ig strand G	495..505	CDD:409353
		FN3	510..605	CDD:238020
		FN3	622..703	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910