DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-epsilon and Kirrel2

DIOPT Version :9

Sequence 1:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_038957463.1	Gene:	Kirrel2 / 100359836	RGDID:	1308456	Length:	711	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	105/560 - (18%)
Similarity:	178/560 - (31%)	Gaps:	185/560 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 STLNNVISEDPEFTDVIENITVPAGRNVKLACSVKNLGSYK--VAWMHFEQSAILTVHNHVITRN 104
            |.:..::...|.|....|::.|..|:..:|.|:   ||:|:  |.|                |::
  Rat    22 SAIPLLLGSSPHFLQQPEDMVVLLGQEARLPCA---LGAYRGLVQW----------------TKD 67

  Fly   105 P-RISVTHDKHDKHRTWF----------LHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPN 158
            . .:....|.....|.|.          |||..|:.||...|.||.:....:::...:.|:|||.
  Rat    68 GLALGGERDLPGWSRYWISGNSASGQHDLHIKPVELEDEASYECQASQAGLRSRPAQLHVMVPPE 132

  Fly   159 IDDALTSSDIIVREGDNVTLRCKAKGS--PEPTIKWKRD----DGNKIVINKTLEVHDLETDSLE 217
            ....|....:.:..|....|.|:::|.  |.|.:.|.||    ||...   ..:.:.|..|.::|
  Rat   133 APQVLGGPSVSLVAGVPGNLTCRSRGDARPAPELLWFRDGIRLDGTSF---HQITLRDKATGTVE 194

  Fly   218 ----LERISRLHMGAYLCIA-SNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIE 277
                |...|:......:|.| |..:|......:.:|:.:.|||.:..:......|..:|..|...
  Rat   195 NTLFLTPSSQDDGATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTAQEGEKVTFLCQAT 259

  Fly   278 ANPTSLNY-WTRENDQM---------ITESSKYKTETIP-------------------------- 306
            |.|....| |.:....:         :...:.:.||.:.
  Rat   260 AQPPVTGYRWAKGGSPVLGARGPRLEVVADATFLTEPVSCEVSNAVGSANRSTALEVLYGPILQA 324

  Fly   307 --------------------GHP---------------SYKATMRLTITNVQSSDYGNYKCVAKN 336
                                |:|               |...|:||  .:|...|.|:|.|.|:.
  Rat   325 KPKPVSVDVGKDASFSCVWRGNPLPRISWTRLGGSQVLSSGPTLRL--PSVALEDAGDYVCRAEP 387

  Fly   337 PRGDMDG---NIKLYMSSPP-TTQPPPTTTTLRRT--------TTTAAEIALDGYINTPLNGNGI 389
            .|..:.|   ..:|.:::|| .|...|....||..        .:.|.:..:..:....|....:
  Rat   388 RRTGVGGGTAQARLTVNAPPVVTALHPAPAFLRGPARLQCVVFASPAPDSVVWSWDEGFLEAGSL 452

  Fly   390 G--IV----------GEGPTNSVIASGKSSIKYLSNLNEIDKSKQKLTGSSPKGFDWS------- 435
            |  :|          |:||       |..|:.::|...|.|.:         .||:.|
  Rat   453 GRFLVEAFPAPEVEGGQGP-------GLISVLHISGTQESDFT---------TGFNCSARNRLGE 501

  Fly   436 -------------------KGKSSGSHGNLMASSWPLICC 456
                               .|.:|.:....|..:..::||
  Rat   502 GRVQIHLGRRDLLPTVRLVAGAASAATSLFMVITGVVLCC 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/108 (22%)
		Ig	69..139	CDD:143165	19/82 (23%)
		IG_like	165..249	CDD:214653	20/94 (21%)
		IGc2	172..237	CDD:197706	19/75 (25%)
		IG_like	267..348	CDD:214653	23/154 (15%)
		Ig	270..339	CDD:299845	20/139 (14%)
Kirrel2	XP_038957463.1	IG_like	38..127	CDD:214653	23/107 (21%)
		Ig strand A'	40..44	CDD:409353	0/3 (0%)
		Ig strand B	48..57	CDD:409353	3/11 (27%)
		Ig strand C	62..66	CDD:409353	2/19 (11%)
		Ig strand D	75..85	CDD:409353	2/9 (22%)
		Ig strand E	88..100	CDD:409353	3/11 (27%)
		Ig strand F	107..115	CDD:409353	3/7 (43%)
		Ig strand G	117..127	CDD:409353	0/9 (0%)
		Ig	133..231	CDD:416386	21/100 (21%)
		Ig strand A	134..137	CDD:409353	0/2 (0%)
		Ig strand A'	140..144	CDD:409353	0/3 (0%)
		Ig strand B	151..158	CDD:409353	2/6 (33%)
		Ig strand C	164..169	CDD:409353	1/4 (25%)
		Ig strand C'	172..174	CDD:409353	0/1 (0%)
		Ig strand D	177..184	CDD:409353	1/9 (11%)
		Ig strand E	191..199	CDD:409353	1/7 (14%)
		Ig strand F	208..216	CDD:409353	2/7 (29%)
		Ig strand G	222..228	CDD:409353	0/5 (0%)
		Ig_3	234..303	CDD:404760	12/68 (18%)
		Ig strand B	252..256	CDD:409353	1/3 (33%)
		Ig strand C	266..270	CDD:409353	1/3 (33%)
		Ig strand E	283..286	CDD:409353	0/2 (0%)
		Ig strand F	292..301	CDD:409353	2/8 (25%)
		Ig strand G	309..312	CDD:409353	0/2 (0%)
		Ig	326..403	CDD:416386	15/78 (19%)
		Ig strand A'	327..332	CDD:409353	0/4 (0%)
		Ig strand B	335..344	CDD:409353	0/8 (0%)
		Ig strand C	350..354	CDD:409353	0/3 (0%)
		Ig strand C'	357..359	CDD:409353	0/1 (0%)
		Ig strand D	362..365	CDD:409353	1/2 (50%)
		Ig strand E	366..371	CDD:409353	3/6 (50%)
		Ig strand F	379..387	CDD:409353	4/7 (57%)
		Ig strand G	393..403	CDD:409353	2/9 (22%)
		Ig	405..509	CDD:416386	21/119 (18%)
		Ig strand A	406..410	CDD:409353	2/3 (67%)
		Ig strand A'	412..415	CDD:409353	0/2 (0%)
		Ig strand B	423..430	CDD:409353	0/6 (0%)
		Ig strand C	437..442	CDD:409353	0/4 (0%)
		Ig strand C'	444..447	CDD:409353	0/2 (0%)
		Ig strand D	455..462	CDD:409353	1/6 (17%)
		Ig strand E	472..479	CDD:409353	2/6 (33%)
		Ig strand F	490..497	CDD:409353	3/6 (50%)
		Ig strand G	500..507	CDD:409353	0/6 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810